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TRIM37 and TRAF5
Number of citations of the paper that reports this interaction (PMID
11279055
)
30
Data Source:
BioGRID
(pull down)
HPRD
(in vitro)
TRIM37
TRAF5
Gene Name
tripartite motif containing 37
TNF receptor-associated factor 5
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Peroxisome
Cytosol
Aggresome
ESC/E(Z) Complex
Perinuclear Region Of Cytoplasm
Cytoplasm
Centrosome
Cytosol
Cytoplasmic Side Of Plasma Membrane
CD40 Receptor Complex
Molecular Function
Chromatin Binding
Ubiquitin-protein Transferase Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Ligase Activity
Ubiquitin Protein Ligase Binding
Protein Homodimerization Activity
Ubiquitin Protein Ligase Activity
Ubiquitin-protein Transferase Activity
Signal Transducer Activity
Protein Binding
Zinc Ion Binding
Ubiquitin Protein Ligase Binding
Thioesterase Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of NF-kappaB Transcription Factor Activity
Histone H2A Monoubiquitination
Histone H2A-K119 Monoubiquitination
Negative Regulation Of Centriole Replication
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Autoubiquitination
Aggresome Assembly
Apoptotic Process
Signal Transduction
Positive Regulation Of Cell Proliferation
Protein Ubiquitination
Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Drugs
Diseases
GWAS
Testicular germ cell tumor (
23666239
)
Protein-Protein Interactions
59 interactors:
ANKRD11
APEX2
APTX
ARNT2
BYSL
CCDC33
CDC20B
CDK5RAP2
COPB1
CWF19L2
DDX6
DLGAP5
EWSR1
FAM107A
FAM124B
FAM161A
FAM50B
FXR2
KAT5
KIAA0408
KIF9
LTBR
MAGEB18
MCM10
MCRS1
NGFR
NUDT18
PBK
PNKP
PRC1
RASD1
RHPN1
RIBC2
RPL9
SCNM1
SSX2IP
TANK
TCEB3B
TNFRSF1B
TRAF1
TRAF2
TRAF3
TRAF4
TRAF5
TRAF6
UBASH3A
UBB
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2H
UBE2U
ZMAT2
ZNF329
ZNF417
ZNF655
42 interactors:
CAPNS1
CCDC184
CD27
CD40
COG7
COMMD3
DGKH
ENOX2
GORASP2
LTBR
MAP3K14
MAP3K5
MAVS
MDM2
NGFRAP1
NMI
NUMBL
RAD23A
RIPK1
RIPK2
RNF111
SDCBP
SEC13
SERPINB9
TDP2
THAP1
TNFRSF11A
TNFRSF12A
TNFRSF13B
TNFRSF14
TNFRSF19
TNFRSF4
TNFRSF8
TRAF2
TRAF3
TRAF3IP2
TRAF6
TRIM27
TRIM37
TRIM8
USP7
ZFAND6
Entrez ID
4591
7188
HPRD ID
05463
03834
Ensembl ID
ENSG00000108395
ENSG00000082512
Uniprot IDs
A8K0V9
A8K8U4
F8WEE6
O94972
D3DT93
O00463
PDB IDs
3LRQ
Enriched GO Terms of Interacting Partners
?
Protein Polyubiquitination
TRIF-dependent Toll-like Receptor Signaling Pathway
Protein K48-linked Ubiquitination
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Toll-like Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Positive Regulation Of Innate Immune Response
Cellular Macromolecule Catabolic Process
Regulation Of Innate Immune Response
Protein K11-linked Ubiquitination
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Protein K63-linked Ubiquitination
Cellular Response To Stress
Catabolic Process
Polynucleotide 3' Dephosphorylation
Apoptotic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Protein Catabolic Process
Immune Response-regulating Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of DNA-templated Transcription In Response To Stress
Programmed Cell Death
I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Mitotic Cell Cycle Phase Transition
Cellular Response To DNA Damage Stimulus
Regulation Of Cell Cycle Phase Transition
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Proteolysis
Cell Death
Death
Activation Of NF-kappaB-inducing Kinase Activity
Modification-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of NIK/NF-kappaB Signaling
Cellular Protein Catabolic Process
DNA Repair
Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Proteolysis
Regulation Of Stress-activated MAPK Cascade
NIK/NF-kappaB Signaling
Regulation Of NIK/NF-kappaB Signaling
Regulation Of Metabolic Process
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Programmed Cell Death
Cell Death
Death
Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of JNK Cascade
Cellular Response To Stimulus
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Immune System Process
Regulation Of Protein Metabolic Process
Cellular Response To Tumor Necrosis Factor
Positive Regulation Of Signal Transduction
Regulation Of JNK Cascade
Immune Response
Signal Transduction
Apoptotic Process
Regulation Of Stress-activated MAPK Cascade
Response To Tumor Necrosis Factor
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Cellular Protein Metabolic Process
Signaling
Positive Regulation Of MAPK Cascade
Cell Communication
Cellular Response To Organic Substance
Regulation Of Apoptotic Process
Response To Stimulus
Positive Regulation Of Phosphorylation
Regulation Of Intracellular Signal Transduction
Regulation Of Cytokine Production
Response To Cytokine
Regulation Of Phosphorylation
Regulation Of Cell Death
Cellular Response To Cytokine Stimulus
Positive Regulation Of MAP Kinase Activity
Cytokine-mediated Signaling Pathway
Cell Surface Receptor Signaling Pathway
Regulation Of MAPK Cascade
Response To Organic Substance
Regulation Of Immunoglobulin Secretion
Positive Regulation Of Protein Metabolic Process
Regulation Of Phosphorus Metabolic Process
Regulation Of Immune System Process
Regulation Of Lymphocyte Activation
Defense Response
Positive Regulation Of Protein Serine/threonine Kinase Activity
Tagcloud
?
adhesion
affinity
bind
cd40
cd40ct
cytoplasmic
dispensable
dominantly
extensive
icam
ikappabalpha
implicated
incapable
intercellular
jak3
kappab
mediators
molecule
much
mutants
necrosis
residues
strongly
tail
traf2
traf3
traf6
transduction
Tagcloud (Difference)
?
adhesion
affinity
bind
cd40
cd40ct
cytoplasmic
dispensable
dominantly
extensive
icam
ikappabalpha
implicated
incapable
intercellular
jak3
kappab
mediators
molecule
much
mutants
necrosis
residues
strongly
tail
traf2
traf3
traf6
transduction
Tagcloud (Intersection)
?