TRIM37 and CDK5RAP2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TRIM37	CDK5RAP2
Gene Name		tripartite motif containing 37	CDK5 regulatory subunit associated protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Peroxisome Cytosol Aggresome ESC/E(Z) Complex Perinuclear Region Of Cytoplasm	Pericentriolar Material Spindle Pole Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Microtubule Cell Junction Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity	Protein Binding Calmodulin Binding Microtubule Binding Tubulin Binding Protein Kinase Binding Transcription Regulatory Region DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of NF-kappaB Transcription Factor Activity Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination Negative Regulation Of Centriole Replication Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Aggresome Assembly	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule Bundle Formation Organelle Organization Chromosome Segregation Brain Development Neurogenesis Regulation Of Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Centriole Replication Centrosome Organization Regulation Of Spindle Checkpoint
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Testicular germ cell tumor ( 23666239)	Response to statin therapy ( 20339536)
Protein-Protein Interactions		59 interactors: ANKRD11 APEX2 APTX ARNT2 BYSL CCDC33 CDC20B CDK5RAP2 COPB1 CWF19L2 DDX6 DLGAP5 EWSR1 FAM107A FAM124B FAM161A FAM50B FXR2 KAT5 KIAA0408 KIF9 LTBR MAGEB18 MCM10 MCRS1 NGFR NUDT18 PBK PNKP PRC1 RASD1 RHPN1 RIBC2 RPL9 SCNM1 SSX2IP TANK TCEB3B TNFRSF1B TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 UBASH3A UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2U ZMAT2 ZNF329 ZNF417 ZNF655	24 interactors: ABCA2 C14orf1 CDK5 CDK5R1 CRMP1 EEF1G FBXO25 HAP1 KAT5 LUC7L2 MAGEH1 MAPRE1 NEFL PCBD1 PTN RBM48 REPS2 SENP2 STARD9 STK36 TBC1D4 TRIM37 TSNAX ZPR1
Entrez ID		4591	55755
HPRD ID		05463	09740
Ensembl ID		ENSG00000108395	ENSG00000136861
Uniprot IDs		A8K0V9 A8K8U4 F8WEE6 O94972	B3KVI2 B9EG74 Q7Z3M0 Q96SN8
PDB IDs		3LRQ
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination TRIF-dependent Toll-like Receptor Signaling Pathway Protein K48-linked Ubiquitination MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Protein Ubiquitination Protein Modification By Small Protein Conjugation Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Cellular Macromolecule Catabolic Process Regulation Of Innate Immune Response Protein K11-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K63-linked Ubiquitination Cellular Response To Stress Catabolic Process Polynucleotide 3' Dephosphorylation Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein Catabolic Process Immune Response-regulating Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of DNA-templated Transcription In Response To Stress Programmed Cell Death I-kappaB Kinase/NF-kappaB Signaling Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To DNA Damage Stimulus Regulation Of Cell Cycle Phase Transition Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Cell Death Death Activation Of NF-kappaB-inducing Kinase Activity Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of NIK/NF-kappaB Signaling Cellular Protein Catabolic Process DNA Repair Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Proteolysis Regulation Of Stress-activated MAPK Cascade NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Regulation Of Metabolic Process	Serine Phosphorylation Of STAT3 Protein Regulation Of Protein Binding Serine Phosphorylation Of STAT Protein Regulation Of Microtubule-based Process Retrograde Axon Cargo Transport Regulation Of Intracellular Transport Cell Projection Organization Regulation Of Neuron Apoptotic Process Regulation Of Cell Cycle Process Regulation Of Binding Limbic System Development Regulation Of Neuron Death Regulation Of Organelle Organization Axon Development Cerebellum Development Microtubule-based Movement Cellular Component Assembly Metencephalon Development Negative Regulation Of Axon Extension Movement Of Cell Or Subcellular Component Anterograde Axon Cargo Transport Regulation Of Microtubule Cytoskeleton Organization Regulation Of Axonogenesis Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Intracellular Protein Transport Hindbrain Development Microtubule-based Process Layer Formation In Cerebral Cortex Positive Regulation Of Receptor Activity Nervous System Development Neuron Projection Development Cerebral Cortex Radial Glia Guided Migration Regulation Of Cell Morphogenesis Peptidyl-threonine Phosphorylation Negative Regulation Of Neuron Death Cell Projection Morphogenesis Regulation Of Dendritic Spine Development Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Pre-mRNA Catabolic Process DNA Endoreduplication Regulation Of Cell Projection Organization Cell Part Morphogenesis Axon Cargo Transport Regulation Of Cytoskeleton Organization Response To Organic Cyclic Compound Positive Regulation Of Intracellular Transport Regulation Of Cell Cycle Organelle Organization
Tagcloud ?			acentrosomal associates centrosomal centrosomin contains fam128a gamma gcp2 impairs melanogaster microcephaly microtubule microtubules mto1p nme7 nucleating nucleation pcp1p pombe referred regrowth schizosaccharomyces stimulates tethering tubulin tuc tuna turc unaffected
Tagcloud (Difference) ?			acentrosomal associates centrosomal centrosomin contains fam128a gamma gcp2 impairs melanogaster microcephaly microtubule microtubules mto1p nme7 nucleating nucleation pcp1p pombe referred regrowth schizosaccharomyces stimulates tethering tubulin tuc tuna turc unaffected
Tagcloud (Intersection) ?