TRIM37 and CDC20B

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		TRIM37	CDC20B
Gene Name		tripartite motif containing 37	cell division cycle 20B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Peroxisome Cytosol Aggresome ESC/E(Z) Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of NF-kappaB Transcription Factor Activity Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination Negative Regulation Of Centriole Replication Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Aggresome Assembly
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Testicular germ cell tumor ( 23666239)
Protein-Protein Interactions		59 interactors: ANKRD11 APEX2 APTX ARNT2 BYSL CCDC33 CDC20B CDK5RAP2 COPB1 CWF19L2 DDX6 DLGAP5 EWSR1 FAM107A FAM124B FAM161A FAM50B FXR2 KAT5 KIAA0408 KIF9 LTBR MAGEB18 MCM10 MCRS1 NGFR NUDT18 PBK PNKP PRC1 RASD1 RHPN1 RIBC2 RPL9 SCNM1 SSX2IP TANK TCEB3B TNFRSF1B TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 UBASH3A UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2U ZMAT2 ZNF329 ZNF417 ZNF655	12 interactors: CCDC57 GOLGA2 KRT31 KRT40 MAGEA11 MTUS2 PLK2 SPAG5 TRAF2 TRIM23 TRIM27 TRIM37
Entrez ID		4591	166979
HPRD ID		05463	13428
Ensembl ID		ENSG00000108395	ENSG00000164287
Uniprot IDs		A8K0V9 A8K8U4 F8WEE6 O94972	Q86Y33
PDB IDs		3LRQ
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination TRIF-dependent Toll-like Receptor Signaling Pathway Protein K48-linked Ubiquitination MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Protein Ubiquitination Protein Modification By Small Protein Conjugation Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Cellular Macromolecule Catabolic Process Regulation Of Innate Immune Response Protein K11-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K63-linked Ubiquitination Cellular Response To Stress Catabolic Process Polynucleotide 3' Dephosphorylation Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein Catabolic Process Immune Response-regulating Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of DNA-templated Transcription In Response To Stress Programmed Cell Death I-kappaB Kinase/NF-kappaB Signaling Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To DNA Damage Stimulus Regulation Of Cell Cycle Phase Transition Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Cell Death Death Activation Of NF-kappaB-inducing Kinase Activity Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of NIK/NF-kappaB Signaling Cellular Protein Catabolic Process DNA Repair Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Proteolysis Regulation Of Stress-activated MAPK Cascade NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Regulation Of Metabolic Process	Regulation Of Centriole Replication Regulation Of Microtubule Cytoskeleton Organization Regulation Of Cytoskeleton Organization Regulation Of Protein Binding Regulation Of Microtubule-based Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein K63-linked Ubiquitination Protein Trimerization Regulation Of Binding Protein Autoubiquitination Regulation Of Centrosome Duplication Regulation Of Centrosome Cycle Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Organelle Organization Positive Regulation Of Protein Binding Negative Regulation Of Interleukin-2 Secretion Positive Regulation Of Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Spindle Organization Histone H2A-K119 Monoubiquitination Protein Polyubiquitination Mitotic Cell Cycle Regulation Of Protein Localization Cellular Protein Modification Process Regulation Of Adaptive Immune Response Negative Regulation Of Centriole Replication Negative Regulation Of Calcium Ion Import Negative Regulation Of Dendritic Spine Development Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Cellular Component Organization Interferon-gamma Secretion Rap Protein Signal Transduction Positive Regulation Of Protein Homodimerization Activity Cellular Response To Nitric Oxide Regulation Of Cellular Localization Histone H2A Monoubiquitination Aggresome Assembly Positive Regulation Of Proteolysis Regulation Of Immunoglobulin Secretion Response To Nitric Oxide Cytoskeleton Organization Negative Regulation Of Viral Release From Host Cell Histone H2A Ubiquitination Negative Regulation Of Centrosome Duplication Negative Regulation Of Dendrite Development Regulation Of Attachment Of Spindle Microtubules To Kinetochore Long Term Synaptic Depression Protein Homotrimerization
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