TRIM37 and PRC1

Number of citations of the paper that reports this interaction (PubMedID 19447967)
24

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TRIM37	PRC1
Description		tripartite motif containing 37	protein regulator of cytokinesis 1
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GO Annotations	Cellular Component	Chromosome Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Membrane Aggresome ESC/E(Z) Complex Perinuclear Region Of Cytoplasm	Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule Plasma Membrane Microtubule Cytoskeleton Midbody Intercellular Bridge Contractile Ring Mitotic Spindle Midzone
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Histone H2AK119 Ubiquitin Ligase Activity	Protein Binding Microtubule Binding Kinesin Binding Protein Kinase Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Monoubiquitination Protein Import Into Peroxisome Matrix Protein Ubiquitination Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of DNA-templated Transcription Negative Regulation Of Centriole Replication Protein Stabilization Protein Autoubiquitination Aggresome Assembly	Mitotic Spindle Elongation Microtubule Cytoskeleton Organization Positive Regulation Of Cell Population Proliferation Regulation Of Cytokinesis Mitotic Spindle Midzone Assembly Cell Division
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	RHO GTPases activate CIT
Drugs
Diseases
GWAS		Cognitive function ( 25644384) General cognitive ability ( 29844566) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278) Testicular germ cell tumor ( 23666239)	Breast cancer ( 25038754 29059683) Mean platelet volume ( 27863252 32888494) Multisite chronic pain ( 31194737 33830993) Red cell distribution width ( 32888494) Type 2 diabetes ( 20581827 22885922 24509480 26818947 28869590 30054458 30297969 30718926 32499647)
Interacting Genes		76 interacting genes: ANKRD11 APEX2 APTX AQP1 ARNT2 AXIN1 BASP1 BYSL CCDC33 CDC20B CDC7 CDK5RAP2 CDKL3 COPB1 CWF19L2 DDX6 DLGAP5 DSCAM DTNB DZIP1L ELOA ELOA2 EWSR1 FAM107A FAM124B FAM161A FAM50B FXR2 H2AC20 H2AC4 IKBKG KAT5 KIAA0408 KIF9 LTBR MAGEB18 MCM10 MCRS1 NGFR NUDT18 PABPC4 PBK PNKP PRC1 RASD1 RHPN1 RIBC2 RNF6 RPL9 RXRB SCNM1 SYTL4 TCEANC TNFRSF1B TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 UBASH3A UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2U ZBTB24 ZMAT2 ZNF329 ZNF417 ZNF587 ZNF655	43 interacting genes: AKAP9 BICD2 CASK CCDC85B CCNA2 CCNB1 CCNE1 CDK1 CDK2 CEBPA CINP EMG1 EXOSC7 EXOSC8 FXR2 KIF3B KIF4A KLC2 KLC4 KRT20 LARP4 MAT2A NDEL1 NUDT16 OGT PBK PCM1 PKIA PLK1 PPIE RACGAP1 RBM10 RBM17 RBM22 RPA2 SF3B2 SLAIN1 SUMO2 TFIP11 THOC1 TRIM37 USHBP1 YWHAE
Entrez ID		4591	9055
HPRD ID		05463	17899
Ensembl ID		ENSG00000108395	ENSG00000198901
Uniprot IDs		O94972	O43663
PDB IDs		3LRQ	3NRX 3NRY 4L3I 4L6Y 5KMG 7VBG
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Nucleus Thioesterase Binding Protein K48-linked Ubiquitination Signaling Adaptor Activity Protein Polyubiquitination Tumor Necrosis Factor Receptor Binding Ubiquitin-protein Transferase Activity Ubiquitin Protein Ligase Binding CD40 Receptor Complex Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Zinc Ion Binding Protein Binding Protein Ubiquitination Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Polynucleotide 3'-phosphatase Activity Regulation Of Gene Expression Positive Regulation Of NF-kappaB Transcription Factor Activity Protein K11-linked Ubiquitination Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process DNA Damage Response Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Post-translational Protein Modification Regulation Of Canonical NF-kappaB Signal Transduction Protein Monoubiquitination Elongin Complex Tumor Necrosis Factor Receptor Superfamily Complex ISG15 Transferase Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of DNA-binding Transcription Factor Activity Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Proteasomal Protein Catabolic Process Protein Autoubiquitination	Microtubule-based Process Nucleic Acid Metabolic Process Organelle Organization Microtubule Cytoskeleton Organization G2/M Transition Of Mitotic Cell Cycle Cytoskeleton Cell Cycle G2/M Phase Transition Cytoskeleton Organization Nucleobase-containing Compound Metabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Cell Cycle Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Process Mitotic Cell Cycle Phase Transition Cytoplasm G1/S Transition Of Mitotic Cell Cycle Regulation Of Intracellular Protein Transport MRNA Metabolic Process Cell Cycle G1/S Phase Transition Nucleoplasm Nucleus Cell Cycle Phase Transition Centrosome Separation Centrosome Spindle Microtubule Microtubule Organizing Center RNA Metabolic Process Regulation Of Intracellular Transport Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process Kinesin Complex Cyclin A2-CDK1 Complex Cyclin B1-CDK1 Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle MRNA Splicing, Via Spliceosome Regulation Of Proteasomal Protein Catabolic Process RNA Binding Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Nucleocytoplasmic Transport RNA Splicing, Via Transesterification Reactions Cell Division Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Cyclin-dependent Protein Kinase Activity U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Regulation Of Mitotic Cell Cycle Phase Transition Protein Localization To Organelle Regulation Of Attachment Of Spindle Microtubules To Kinetochore Mitotic DNA Damage Checkpoint Signaling
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