TRIM37 and RASD1

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		TRIM37	RASD1
Name		tripartite motif containing 37	ras related dexamethasone induced 1
Structure			No pdb structure
GO Annotations	Cellular Component	Chromosome Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Membrane Aggresome ESC/E(Z) Complex Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Plasma Membrane Membrane Sarcoplasmic Reticulum Perinuclear Region Of Cytoplasm
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Histone H2AK119 Ubiquitin Ligase Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding G-protein Beta-subunit Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Monoubiquitination Protein Import Into Peroxisome Matrix Protein Ubiquitination Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of DNA-templated Transcription Negative Regulation Of Centriole Replication Protein Stabilization Protein Autoubiquitination Aggresome Assembly	Signal Transduction G Protein-coupled Receptor Signaling Pathway Nitric Oxide Mediated Signal Transduction Negative Regulation Of DNA-templated Transcription
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	None
GWAS		Cognitive function ( 25644384 ) General cognitive ability ( 29844566 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Refractive error ( 32231278 ) Testicular germ cell tumor ( 23666239 )	A body shape index ( 34021172 ) Chronotype ( 30696823 ) Coronary artery disease ( 24262325 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Coronary artery disease or ischemic stroke ( 24262325 ) Coronary artery disease or large artery stroke ( 24262325 ) Coronary heart disease ( 21378990 ) Morning person ( 30696823 ) Morning vs. evening chronotype ( 26835600 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		76 interacting genes: ANKRD11 APEX2 APTX AQP1 ARNT2 AXIN1 BASP1 BYSL CCDC33 CDC20B CDC7 CDK5RAP2 CDKL3 COPB1 CWF19L2 DDX6 DLGAP5 DSCAM DTNB DZIP1L ELOA ELOA2 EWSR1 FAM107A FAM124B FAM161A FAM50B FXR2 H2AC20 H2AC4 IKBKG KAT5 KIAA0408 KIF9 LTBR MAGEB18 MCM10 MCRS1 NGFR NUDT18 PABPC4 PBK PNKP PRC1 RASD1 RHPN1 RIBC2 RNF6 RPL9 RXRB SCNM1 SYTL4 TCEANC TNFRSF1B TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 UBASH3A UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2U ZBTB24 ZMAT2 ZNF329 ZNF417 ZNF587 ZNF655	38 interacting genes: ABI2 BHLHE41 CCDC57 CDR2L CYSRT1 EXOSC8 GNAI1 GNAI2 GNB1 HNRNPK HNRNPR KHDRBS3 KRT34 KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP10-9 KRTAP26-1 KRTAP5-9 KRTAP6-2 KRTAP6-3 MATR3 MDFI MKRN3 MTUS2 NBPF19 NOS1 NOS1AP NOTCH2NLA PLSCR1 PRDM5 PTPN21 RASAL3 RBMY1A1 RBMY1F RBMY1J TRIM37 WWP2
Entrez ID		4591	51655
HPRD ID		05463	08958
Ensembl ID		ENSG00000108395	ENSG00000108551
Uniprot IDs		O94972	Q9Y272
PDB IDs		3LRQ	Not available
GO Terms Enriched among Interactors		Ubiquitin Conjugating Enzyme Activity Nucleus Thioesterase Binding Protein K48-linked Ubiquitination Signaling Adaptor Activity Protein Polyubiquitination Tumor Necrosis Factor Receptor Binding Ubiquitin-protein Transferase Activity Ubiquitin Protein Ligase Binding CD40 Receptor Complex Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Zinc Ion Binding Protein Binding Protein Ubiquitination Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Polynucleotide 3'-phosphatase Activity Regulation Of Gene Expression Positive Regulation Of NF-kappaB Transcription Factor Activity Protein K11-linked Ubiquitination Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process DNA Damage Response Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Post-translational Protein Modification Regulation Of Canonical NF-kappaB Signal Transduction Protein Monoubiquitination Elongin Complex Tumor Necrosis Factor Receptor Superfamily Complex ISG15 Transferase Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of DNA-binding Transcription Factor Activity Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Proteasomal Protein Catabolic Process Protein Autoubiquitination	Intermediate Filament Keratin Filament Identical Protein Binding Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Positive Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Positive Regulation Of MRNA Splicing, Via Spliceosome Heterotrimeric G-protein Complex Spliceosomal Complex Regulation Of RNA Splicing Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Positive Regulation Of RNA Splicing Regulation Of Membrane Repolarization During Action Potential Nucleic Acid Binding MRNA Metabolic Process MRNA Processing Guanyl Nucleotide Binding Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of MRNA Metabolic Process Nucleolus Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Potassium Ion Transport Nitric Oxide Biosynthetic Process G-protein Beta/gamma-subunit Complex Binding Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization RNA Splicing Protein Binding