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UBE3A and LCK
Number of citations of the paper that reports this interaction (PubMedID
10449731
)
36
Data Source:
BioGRID
(pull down)
UBE3A
LCK
Description
ubiquitin protein ligase E3A
LCK proto-oncogene, Src family tyrosine kinase
Image
GO Annotations
Cellular Component
Proteasome Complex
Nucleus
Cytoplasm
Cytosol
Synaptic Vesicle
Glutamatergic Synapse
Postsynaptic Cytosol
Pericentriolar Material
Immunological Synapse
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Membrane
Membrane Raft
Extracellular Exosome
Molecular Function
Transcription Coactivator Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Nucleotide Binding
Phosphotyrosine Residue Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Serine/threonine Phosphatase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Phospholipase Activator Activity
Kinase Activity
Transferase Activity
Protein Kinase Binding
Protein Phosphatase Binding
SH2 Domain Binding
T Cell Receptor Binding
CD4 Receptor Binding
CD8 Receptor Binding
Identical Protein Binding
Phospholipase Binding
Phosphatidylinositol 3-kinase Binding
ATPase Binding
Protein Antigen Binding
Biological Process
Protein Polyubiquitination
Ovarian Follicle Development
Proteolysis
Ubiquitin-dependent Protein Catabolic Process
Brain Development
Positive Regulation Of Macromolecule Metabolic Process
Protein Ubiquitination
Nuclear Receptor-mediated Steroid Hormone Signaling Pathway
Androgen Receptor Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Cellular Response To Nutrient Levels
Response To Progesterone
Sperm Entry
Regulation Of Circadian Rhythm
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Synaptic Plasticity
Rhythmic Process
Animal Organ Development
System Development
Modulation Of Chemical Synaptic Transmission
Progesterone Receptor Signaling Pathway
Protein Autoubiquitination
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Prostate Gland Growth
Protein K48-linked Ubiquitination
Regulation Of Primary Metabolic Process
Positive Regulation Of Protein Localization To Lysosome
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Positive Regulation Of Golgi Lumen Acidification
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Immune Response-activating Cell Surface Receptor Signaling Pathway
Protein Phosphorylation
Intracellular Zinc Ion Homeostasis
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Response To Xenobiotic Stimulus
Positive Regulation Of Gene Expression
Peptidyl-tyrosine Phosphorylation
Hemopoiesis
Platelet Activation
T Cell Differentiation
T Cell Costimulation
Positive Regulation Of Heterotypic Cell-cell Adhesion
Intracellular Signal Transduction
Peptidyl-tyrosine Autophosphorylation
Fc-gamma Receptor Signaling Pathway
T Cell Activation
Gamma-delta T Cell Differentiation
Positive Regulation Of MAPK Cascade
Positive Regulation Of Gamma-delta T Cell Differentiation
Regulation Of Regulatory T Cell Differentiation
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Activation
Leukocyte Migration
Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Multicellular Organismal Process
Regulation Of Lymphocyte Activation
CD27 Signaling Pathway
Positive Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
Nef and signal transduction
Nef Mediated CD4 Down-regulation
Downstream TCR signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PECAM1 interactions
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
DAP12 signaling
Co-stimulation by CD28
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
Co-inhibition by CTLA4
Co-inhibition by PD-1
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RHOH GTPase cycle
Interleukin-2 signaling
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
FLT3 signaling through SRC family kinases
Drugs
Dasatinib
AP-22408
Staurosporine
1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
{4-[(2S)-2-Acetamido-3-({(1S)-1-[3-carbamoyl-4-(cyclohexylmethoxy)phenyl]ethyl}amino)-3-oxopropyl]-2-phosphonophenoxy}acetic acid
Phosphoaminophosphonic Acid-Adenylate Ester
3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE
2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINE
5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE
N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine
N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine
N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amine
Ponatinib
Nintedanib
Fostamatinib
Zanubrutinib
Zotiraciclib
Diseases
Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS
Cardiac hypertrophy (
21348951
)
Gene methylation in lung tissue (
25713168
)
Obesity-related traits (
23251661
)
Multiple sclerosis (
31604244
)
Interacting Genes
165 interacting genes:
ACTA2
ACTB
ACTBL2
ACTR3
ADRM1
AFG3L1P
AFTPH
AHSP
ALDH1A2
ANXA1
APP
AR
ARC
ARHGDIB
ASAP3
ATG9A
BAK1
BARD1
BLK
BPY2
BPY2B
BPY2C
BRCA1
CALR
CAPN3
CDK1
CDK4
CDKN1B
CEBPZ
CGGBP1
CKB
CRP
CSTPP1
CTNNB1
DAZAP2
DDI2
DLG1
DLG4
E2F1
EAPP
EEF1A2
EID1
EIF4G1
EML1
ENO1
ENO2
ESR1
FAF2
GFAP
GOPC
GTF3C1
HBA1
HPCAL4
HSP90AB1
HSPA2
HSPA4
HSPA5
IL24
JADE1
KLHL38
KRT1
KRT5
KRT7
KRT9
LCK
LCN2
MAGEA12
MAGEA8
MAPK1
MAPK10
MARF1
MCM2
MCM4
MCM6
MCM7
MDM1
MDM2
MDM4
MEOX2
MSTO1
MYCBP
MYCN
NBPF14
NDUFA13
NELFCD
NFX1
NHERF1
NOMO2
NR3C1
NR4A3
NUMBL
PAICS
PARVA
PAX5
PAX6
PBRM1
PDE1B
PDIA3
PDIA6
PGK1
PGR
PKM
PML
POLE4
PPIA
PPP1R3F
PRAG1
PRDX1
PRKACA
PRMT5
PRSS1
PSAP
PTCD3
RAD23A
RAD23B
RARA
RMI1
RNF152
RNF2
RPS15A
RYBP
SACS
SCAMP1
SCRIB
SERPINB2
SET
SHBG
SIPA1L1
SIRT6
SMAD9
SNAPC3
SOD1
SPINK1
SUMO3
TALDO1
TAT
TBC1D14
TCF19
TMEM14B
TP53
TP53BP2
TRIM65
TSC2
TTC23L
TTC3
TUBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2G1
UBE2G2
UBE2L3
UBE2L6
UBE2N
UBQLN2
UBR5
WBP2
WDR4
YOD1
YWHAE
YWHAG
ZNF250
ZNF446
142 interacting genes:
ACP1
ADAM15
AJUBA
AR
ARHGAP17
ASB9
AXL
BCAR1
BRCA1
C1QTNF2
CBL
CCR5
CD2
CD247
CD28
CD38
CD3E
CD4
CD44
CD48
CD5
CD55
CD79A
CD79B
CD8A
CDC25C
CDC42
CDC45
CDKAL1
CIMIP2B
CSF2RB
CSF3R
CSK
CSNK2B
CTDSP1
CTLA4
CTNND2
DAPP1
DEF6
DLG1
DOK1
DOK2
DOK3
EGFR
ERBB2
ERBB3
ERBB4
ESR1
ESR2
EZR
FAM174A
FAS
FASLG
FCGR3A
FYN
G3BP1
GAB2
GATA3
GRAP
HSP90AA1
IFNAR1
IKBKG
IL2RB
ITK
JAK3
KHDRBS1
KIR2DL3
KIT
LAT
LAX1
LCP2
LIME1
LZTS2
MAPK1
MAPK3
MAPT
MED28
MET
MS4A1
MUC1
NEDD9
NFKBIA
NFKBID
NOTCH1
NR3C1
PAG1
PAK2
PECAM1
PI4KA
PIK3CA
PIK3R1
PLCG1
PLCG2
PLD2
PRKACA
PRKCA
PRKCD
PRKCQ
PTK2
PTK2B
PTPN11
PTPN22
PTPN6
PTPRC
PTPRF
PTPRH
PXN
RAF1
RASA1
RIN3
RORB
SH2B3
SH2D1A
SH2D2A
SH3BP2
SHC1
SIT1
SKAP1
SKAP2
SMAD2
SMAD3
SMURF1
SOCS1
SOS1
SQSTM1
STAT1
STAT3
STAT5A
SYK
THY1
TRAT1
TRIM35
TRPV4
TUB
UBAP2
UBE3A
UHRF2
UNC119
VAV1
WAS
WASL
ZAP70
Entrez ID
7337
3932
HPRD ID
03375
01080
Ensembl ID
ENSG00000114062
ENSG00000182866
Uniprot IDs
A0A6Q8PHE5
Q05086
Q9H2G0
A0A0S2Z3Y8
E9PJ92
E9PKQ8
P06239
Q573B4
PDB IDs
1C4Z
1D5F
1EQX
2KR1
4GIZ
4XR8
6SJV
6SLM
6TGK
6U19
7Q41
7QPB
8ENP
8EPT
8GCR
8JRN
8JRO
8JRP
8JRQ
8JRR
8R1F
8R1G
9CHT
1BHF
1BHH
1CWD
1CWE
1FBZ
1H92
1IJR
1KIK
1LCJ
1LCK
1LKK
1LKL
1Q68
1Q69
1QPC
1QPD
1QPE
1QPJ
1X27
2IIM
2OF2
2OF4
2OFU
2OFV
2OG8
2PL0
2ZM1
2ZM4
2ZYB
3AC1
3AC2
3AC3
3AC4
3AC5
3AC8
3ACJ
3ACK
3AD4
3AD5
3AD6
3B2W
3BRH
3BYM
3BYO
3BYS
3BYU
3KMM
3KXZ
3LCK
3MPM
4C3F
4D8K
5MTM
5MTN
6H6A
6PDJ
8X2P
Enriched GO Terms of Interacting Partners
?
Cytosol
Nucleus
Cytoplasm
Ubiquitin Protein Ligase Binding
Cellular Response To Stress
Proteolysis Involved In Protein Catabolic Process
Ubiquitin Conjugating Enzyme Activity
Protein Polyubiquitination
Ubiquitin-protein Transferase Activity
Nucleoplasm
Regulation Of Cell Cycle
Regulation Of Macromolecule Metabolic Process
Response To Stress
Protein-containing Complex
Proteasomal Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Regulation Of Mitotic Cell Cycle
Extracellular Exosome
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Programmed Cell Death
Nuclear Receptor-mediated Signaling Pathway
Protein Metabolic Process
Regulation Of Gene Expression
Regulation Of Apoptotic Process
Protein Catabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Primary Metabolic Process
Post-translational Protein Modification
Positive Regulation Of Metabolic Process
Macromolecule Metabolic Process
Protein Binding
Protein Modification By Small Protein Conjugation
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Programmed Cell Death
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Protein Ubiquitination
Positive Regulation Of Biosynthetic Process
Intracellular Signal Transduction
Positive Regulation Of Apoptotic Process
Negative Regulation Of Macromolecule Metabolic Process
Macromolecule Catabolic Process
Enzyme Binding
Identical Protein Binding
Regulation Of DNA-templated Transcription
Signal Transduction
Cell Surface Receptor Signaling Pathway
Immune System Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Immune System Process
Immune Response-activating Cell Surface Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Positive Regulation Of Immune System Process
Immune Response-regulating Signaling Pathway
Regulation Of Immune Response
Immune Response-activating Signaling Pathway
Activation Of Immune Response
Plasma Membrane
Intracellular Signal Transduction
T Cell Receptor Signaling Pathway
Lymphocyte Activation
Positive Regulation Of Immune Response
Leukocyte Activation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Activation
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Intracellular Signal Transduction
Regulation Of Signal Transduction
Regulation Of Cell Adhesion
Immune Response
Adaptive Immune Response
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Cell-cell Adhesion
Regulation Of Lymphocyte Activation
Intracellular Signaling Cassette
Regulation Of Cell Activation
Protein Kinase Binding
Regulation Of T Cell Activation
T Cell Activation
Cytokine-mediated Signaling Pathway
Regulation Of MAPK Cascade
Regulation Of Leukocyte Cell-cell Adhesion
B Cell Receptor Signaling Pathway
Regulation Of Programmed Cell Death
Positive Regulation Of Intracellular Signal Transduction
Phosphotyrosine Residue Binding
Regulation Of Cellular Component Organization
Regulation Of Multicellular Organismal Process
Negative Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
ERBB Signaling Pathway
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Tagcloud (Intersection)
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