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UBE3A and ENO2
Number of citations of the paper that reports this interaction (PubMedID
31329371
)
0
Data Source:
BioGRID
(pull down)
UBE3A
ENO2
Description
ubiquitin protein ligase E3A
enolase 2
Image
GO Annotations
Cellular Component
Proteasome Complex
Nucleus
Cytoplasm
Cytosol
Synaptic Vesicle
Glutamatergic Synapse
Postsynaptic Cytosol
Phosphopyruvate Hydratase Complex
Photoreceptor Inner Segment
Extracellular Space
Cytoplasm
Cytosol
Plasma Membrane
Cell Cortex
Cell Surface
Membrane
Growth Cone
Neuronal Cell Body
Perikaryon
Membrane Raft
Extracellular Exosome
Synaptic Membrane
Molecular Function
Transcription Coactivator Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Magnesium Ion Binding
Phosphopyruvate Hydratase Activity
Protein Binding
Lyase Activity
Enzyme Binding
Identical Protein Binding
Protein-containing Complex Binding
Metal Ion Binding
Biological Process
Protein Polyubiquitination
Ovarian Follicle Development
Proteolysis
Ubiquitin-dependent Protein Catabolic Process
Brain Development
Positive Regulation Of Macromolecule Metabolic Process
Protein Ubiquitination
Nuclear Receptor-mediated Steroid Hormone Signaling Pathway
Androgen Receptor Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Cellular Response To Nutrient Levels
Response To Progesterone
Sperm Entry
Regulation Of Circadian Rhythm
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Synaptic Plasticity
Rhythmic Process
Animal Organ Development
System Development
Modulation Of Chemical Synaptic Transmission
Progesterone Receptor Signaling Pathway
Protein Autoubiquitination
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Prostate Gland Growth
Protein K48-linked Ubiquitination
Regulation Of Primary Metabolic Process
Positive Regulation Of Protein Localization To Lysosome
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Positive Regulation Of Golgi Lumen Acidification
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Gluconeogenesis
Glycolytic Process
Response To Xenobiotic Stimulus
Response To Estradiol
Canonical Glycolysis
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Glycolysis
Gluconeogenesis
Drugs
2-Phosphoglycolic Acid
Diseases
Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS
Cardiac hypertrophy (
21348951
)
Gene methylation in lung tissue (
25713168
)
Obesity-related traits (
23251661
)
Interacting Genes
165 interacting genes:
ACTA2
ACTB
ACTBL2
ACTR3
ADRM1
AFG3L1P
AFTPH
AHSP
ALDH1A2
ANXA1
APP
AR
ARC
ARHGDIB
ASAP3
ATG9A
BAK1
BARD1
BLK
BPY2
BPY2B
BPY2C
BRCA1
CALR
CAPN3
CDK1
CDK4
CDKN1B
CEBPZ
CGGBP1
CKB
CRP
CSTPP1
CTNNB1
DAZAP2
DDI2
DLG1
DLG4
E2F1
EAPP
EEF1A2
EID1
EIF4G1
EML1
ENO1
ENO2
ESR1
FAF2
GFAP
GOPC
GTF3C1
HBA1
HPCAL4
HSP90AB1
HSPA2
HSPA4
HSPA5
IL24
JADE1
KLHL38
KRT1
KRT5
KRT7
KRT9
LCK
LCN2
MAGEA12
MAGEA8
MAPK1
MAPK10
MARF1
MCM2
MCM4
MCM6
MCM7
MDM1
MDM2
MDM4
MEOX2
MSTO1
MYCBP
MYCN
NBPF14
NDUFA13
NELFCD
NFX1
NHERF1
NOMO2
NR3C1
NR4A3
NUMBL
PAICS
PARVA
PAX5
PAX6
PBRM1
PDE1B
PDIA3
PDIA6
PGK1
PGR
PKM
PML
POLE4
PPIA
PPP1R3F
PRAG1
PRDX1
PRKACA
PRMT5
PRSS1
PSAP
PTCD3
RAD23A
RAD23B
RARA
RMI1
RNF152
RNF2
RPS15A
RYBP
SACS
SCAMP1
SCRIB
SERPINB2
SET
SHBG
SIPA1L1
SIRT6
SMAD9
SNAPC3
SOD1
SPINK1
SUMO3
TALDO1
TAT
TBC1D14
TCF19
TMEM14B
TP53
TP53BP2
TRIM65
TSC2
TTC23L
TTC3
TUBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2G1
UBE2G2
UBE2L3
UBE2L6
UBE2N
UBQLN2
UBR5
WBP2
WDR4
YOD1
YWHAE
YWHAG
ZNF250
ZNF446
27 interacting genes:
A2M
ACD
AKT1
ANXA11
BMERB1
C6orf47
ENSA
EXOC5
HABP4
HK1
HSF1
IL17B
MAP4
MTNR1A
NAT9
NDUFS7
POT1
SIGIRR
SNUPN
ST3GAL2
SUMO4
TERF1
TINF2
TUBA4A
UBE2C
UBE3A
USP2-AS1
Entrez ID
7337
2026
HPRD ID
03375
00573
Ensembl ID
ENSG00000114062
ENSG00000111674
Uniprot IDs
A0A6Q8PHE5
Q05086
Q9H2G0
P09104
Q6FHV6
PDB IDs
1C4Z
1D5F
1EQX
2KR1
4GIZ
4XR8
6SJV
6SLM
6TGK
6U19
7Q41
7QPB
8ENP
8EPT
8GCR
8JRN
8JRO
8JRP
8JRQ
8JRR
8R1F
8R1G
9CHT
1TE6
2AKM
2AKZ
3UCC
3UCD
3UJE
3UJF
3UJR
3UJS
4ZA0
4ZCW
5EU9
5IDZ
5TD9
5TIJ
7MBH
Enriched GO Terms of Interacting Partners
?
Cytosol
Nucleus
Cytoplasm
Ubiquitin Protein Ligase Binding
Cellular Response To Stress
Proteolysis Involved In Protein Catabolic Process
Ubiquitin Conjugating Enzyme Activity
Protein Polyubiquitination
Ubiquitin-protein Transferase Activity
Nucleoplasm
Regulation Of Cell Cycle
Regulation Of Macromolecule Metabolic Process
Response To Stress
Protein-containing Complex
Proteasomal Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Regulation Of Mitotic Cell Cycle
Extracellular Exosome
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Programmed Cell Death
Nuclear Receptor-mediated Signaling Pathway
Protein Metabolic Process
Regulation Of Gene Expression
Regulation Of Apoptotic Process
Protein Catabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Primary Metabolic Process
Post-translational Protein Modification
Positive Regulation Of Metabolic Process
Macromolecule Metabolic Process
Protein Binding
Protein Modification By Small Protein Conjugation
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Programmed Cell Death
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Protein Ubiquitination
Positive Regulation Of Biosynthetic Process
Intracellular Signal Transduction
Positive Regulation Of Apoptotic Process
Negative Regulation Of Macromolecule Metabolic Process
Macromolecule Catabolic Process
Enzyme Binding
Identical Protein Binding
Regulation Of DNA-templated Transcription
Shelterin Complex
Nuclear Telomere Cap Complex
Telomere Capping
Telomere Assembly
Negative Regulation Of Telomere Maintenance Via Telomerase
Telomeric DNA Binding
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Negative Regulation Of DNA Biosynthetic Process
Negative Regulation Of Telomere Maintenance
Regulation Of Telomere Maintenance Via Telomerase
Regulation Of Telomere Maintenance Via Telomere Lengthening
Negative Regulation Of DNA Metabolic Process
Positive Regulation Of DNA Metabolic Process
Positive Regulation Of Telomere Maintenance
Telomere Maintenance Via Telomerase
Translation Elongation Factor Binding
Negative Regulation Of Chromosome Organization
RNA-templated DNA Biosynthetic Process
Negative Regulation Of Cellular Component Organization
Regulation Of DNA Biosynthetic Process
Positive Regulation Of Organelle Organization
Telomere Maintenance Via Telomere Lengthening
Telomere Maintenance
Positive Regulation Of Chromosome Organization
Maintenance Of Protein Location In Mitochondrion
Regulation Of Telomere Maintenance
Regulation Of Establishment Of Protein Localization To Telomere
Regulation Of Chromosome Organization
Regulation Of Establishment Of Protein Localization To Chromosome
Telomere Organization
Telomerase Inhibitor Activity
Establishment Of Protein Localization To Telomere
Regulation Of Organelle Organization
Telomeric D-loop Disassembly
G-rich Strand Telomeric DNA Binding
Regulation Of DNA Metabolic Process
Telomeric Loop Disassembly
Protein Localization To Chromosome, Telomeric Region
Chromosome, Telomeric Region
Establishment Of Protein Localization To Organelle
Organelle Organization
DNA Biosynthetic Process
Anaphase-promoting Complex-dependent Catabolic Process
Negative Regulation Of Cilium Assembly
Cell Division
Microtubule Cytoskeleton
Ubiquitin-like Protein Ligase Binding
Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Positive Regulation Of Mitotic Cell Cycle
Regulation Of TRNA Methylation
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