UBE3A and SIRT6

Number of citations of the paper that reports this interaction (PubMedID 29217762)
0

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study)

		UBE3A	SIRT6
Description		ubiquitin protein ligase E3A	sirtuin 6
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GO Annotations	Cellular Component	Proteasome Complex Nucleus Cytoplasm Cytosol Synaptic Vesicle Glutamatergic Synapse Postsynaptic Cytosol	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin Nucleolus Endoplasmic Reticulum Site Of Double-strand Break Site Of DNA Damage Chromosome, Subtelomeric Region
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	DNA Binding Chromatin Binding Damaged DNA Binding Transcription Corepressor Activity RNA Binding NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding Transferase Activity Acyltransferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Histone Deacetylase Activity, NAD-dependent Enzyme Regulator Activity Chromatin DNA Binding Nucleosome Binding Histone H3K9 Deacetylase Activity, Hydrolytic Mechanism NAD-dependent Protein Lysine Deacetylase Activity Histone Deacetylase Regulator Activity Protein Homodimerization Activity Metal Ion Binding Histone H3K9 Deacetylase Activity, NAD-dependent NAD+ Binding Histone H3K18 Deacetylase Activity, NAD-dependent NAD+-protein-arginine ADP-ribosyltransferase Activity DNA Damage Sensor Activity Histone H3K56 Deacetylase Activity, NAD-dependent NAD-dependent Protein Demyristoylase Activity NAD-dependent Protein Depalmitoylase Activity NAD+-protein-lysine ADP-ribosyltransferase Activity TORC2 Complex Binding NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Protein Polyubiquitination Ovarian Follicle Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Brain Development Positive Regulation Of Macromolecule Metabolic Process Protein Ubiquitination Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Cellular Response To Nutrient Levels Response To Progesterone Sperm Entry Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Rhythmic Process Animal Organ Development System Development Modulation Of Chemical Synaptic Transmission Progesterone Receptor Signaling Pathway Protein Autoubiquitination Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Prostate Gland Growth Protein K48-linked Ubiquitination Regulation Of Primary Metabolic Process Positive Regulation Of Protein Localization To Lysosome Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Golgi Lumen Acidification Regulation Of Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Glycolytic Process Regulation Of Gluconeogenesis DNA Repair Regulation Of DNA Repair Base-excision Repair Double-strand Break Repair Chromatin Organization Chromatin Remodeling Protein Deacetylation Protein Import Into Nucleus Inflammatory Response DNA Damage Response Ras Protein Signal Transduction Negative Regulation Of Cell Population Proliferation Determination Of Adult Lifespan Response To UV Transposable Element Silencing Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Lipid Metabolic Process Pericentric Heterochromatin Formation Subtelomeric Heterochromatin Formation Protein Destabilization Positive Regulation Of Insulin Secretion Positive Regulation Of Telomere Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Circadian Regulation Of Gene Expression Negative Regulation Of Transcription Elongation By RNA Polymerase II Ketone Biosynthetic Process Negative Regulation Of Protein Import Into Nucleus Glucose Homeostasis Regulation Of Circadian Rhythm Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Gluconeogenesis Positive Regulation Of Gluconeogenesis Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Glycolytic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of D-glucose Import Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Fibroblast Proliferation Regulation Of Protein Secretion Regulation Of Lipid Catabolic Process Protein Delipidation Cardiac Muscle Cell Differentiation Protein Poly-ADP-ribosylation Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Protein Localization To Chromatin Positive Regulation Of Protein Localization To Chromatin DNA Repair-dependent Chromatin Remodeling Transcription Pausing By RNA Polymerase II Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Chondrocyte Proliferation Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Blood Vessel Branching Positive Regulation Of Vascular Endothelial Cell Proliferation Protein Localization To Site Of Double-strand Break Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Stem Cell Differentiation Negative Regulation Of Cellular Senescence Positive Regulation Of Cellular Senescence Positive Regulation Of Double-strand Break Repair
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Pre-NOTCH Transcription and Translation Processing of DNA double-strand break ends
Drugs
Diseases		Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS		Cardiac hypertrophy ( 21348951) Gene methylation in lung tissue ( 25713168) Obesity-related traits ( 23251661)
Interacting Genes		165 interacting genes: ACTA2 ACTB ACTBL2 ACTR3 ADRM1 AFG3L1P AFTPH AHSP ALDH1A2 ANXA1 APP AR ARC ARHGDIB ASAP3 ATG9A BAK1 BARD1 BLK BPY2 BPY2B BPY2C BRCA1 CALR CAPN3 CDK1 CDK4 CDKN1B CEBPZ CGGBP1 CKB CRP CSTPP1 CTNNB1 DAZAP2 DDI2 DLG1 DLG4 E2F1 EAPP EEF1A2 EID1 EIF4G1 EML1 ENO1 ENO2 ESR1 FAF2 GFAP GOPC GTF3C1 HBA1 HPCAL4 HSP90AB1 HSPA2 HSPA4 HSPA5 IL24 JADE1 KLHL38 KRT1 KRT5 KRT7 KRT9 LCK LCN2 MAGEA12 MAGEA8 MAPK1 MAPK10 MARF1 MCM2 MCM4 MCM6 MCM7 MDM1 MDM2 MDM4 MEOX2 MSTO1 MYCBP MYCN NBPF14 NDUFA13 NELFCD NFX1 NHERF1 NOMO2 NR3C1 NR4A3 NUMBL PAICS PARVA PAX5 PAX6 PBRM1 PDE1B PDIA3 PDIA6 PGK1 PGR PKM PML POLE4 PPIA PPP1R3F PRAG1 PRDX1 PRKACA PRMT5 PRSS1 PSAP PTCD3 RAD23A RAD23B RARA RMI1 RNF152 RNF2 RPS15A RYBP SACS SCAMP1 SCRIB SERPINB2 SET SHBG SIPA1L1 SIRT6 SMAD9 SNAPC3 SOD1 SPINK1 SUMO3 TALDO1 TAT TBC1D14 TCF19 TMEM14B TP53 TP53BP2 TRIM65 TSC2 TTC23L TTC3 TUBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBE2N UBQLN2 UBR5 WBP2 WDR4 YOD1 YWHAE YWHAG ZNF250 ZNF446	18 interacting genes: AKT1 CCNDBP1 CDKN1B CHD3 DDB2 ELF5 FAF1 H3C1 HUS1 MUTYH RAD1 SKP2 STUB1 TDG TSPYL2 UBE2D1 UBE3A VIM
Entrez ID		7337	51548
HPRD ID		03375	12093
Ensembl ID		ENSG00000114062	ENSG00000077463
Uniprot IDs		A0A6Q8PHE5 Q05086 Q9H2G0	B4DDV3 M0QXA0 M0R1N9 Q8N6T7
PDB IDs		1C4Z 1D5F 1EQX 2KR1 4GIZ 4XR8 6SJV 6SLM 6TGK 6U19 7Q41 7QPB 8ENP 8EPT 8GCR 8JRN 8JRO 8JRP 8JRQ 8JRR 8R1F 8R1G 9CHT	3K35 3PKI 3PKJ 3ZG6 5MF6 5MFP 5MFZ 5MGN 5X16 5Y2F 6HOY 6QCD 6QCE 6QCH 6QCJ 6XUY 6XV1 6XV6 6XVG 6ZU4 7CL0 7CL1 8AK5 8AK6 8AK7 8AK8 8AK9 8AKA 8AKB 8AKC 8AKD 8AKE 8AKF 8AKG 8BL0 8BL1 8CNM 8CNO 8F86 8G57 8I2B 8OF4 9G7H
Enriched GO Terms of Interacting Partners?		Cytosol Nucleus Cytoplasm Ubiquitin Protein Ligase Binding Cellular Response To Stress Proteolysis Involved In Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Nucleoplasm Regulation Of Cell Cycle Regulation Of Macromolecule Metabolic Process Response To Stress Protein-containing Complex Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Extracellular Exosome Ubiquitin-dependent Protein Catabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Nuclear Receptor-mediated Signaling Pathway Protein Metabolic Process Regulation Of Gene Expression Regulation Of Apoptotic Process Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Post-translational Protein Modification Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Protein Binding Protein Modification By Small Protein Conjugation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Programmed Cell Death Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Ubiquitination Positive Regulation Of Biosynthetic Process Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Macromolecule Metabolic Process Macromolecule Catabolic Process Enzyme Binding Identical Protein Binding Regulation Of DNA-templated Transcription	Nucleus Nucleoplasm Protein Polyubiquitination Regulation Of Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination DNA Metabolic Process Proteasomal Protein Catabolic Process Cellular Response To Stress Positive Regulation Of Protein Metabolic Process DNA Damage Response DNA Repair Checkpoint Clamp Complex Positive Regulation Of Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Meiotic Cell Cycle Checkpoint Signaling Positive Regulation Of Protein Modification Process Negative Regulation Of TORC1 Signaling Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Reproductive Process Damaged DNA Binding DNA N-glycosylase Activity Protein Modification By Small Protein Conjugation Protein Autoubiquitination Positive Regulation Of Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Cul4A-RING E3 Ubiquitin Ligase Complex Negative Regulation Of TOR Signaling Regulation Of DNA Metabolic Process Ubiquitin-protein Transferase Activity Base-excision Repair, AP Site Formation Regulation Of TORC1 Signaling Post-translational Protein Modification Mammary Gland Epithelial Cell Differentiation Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Metabolic Process Positive Regulation Of DNA Metabolic Process Protein K48-linked Ubiquitination Regulation Of DNA Replication Regulation Of Nucleobase-containing Compound Metabolic Process DNA Modification Regulation Of Protein Polyubiquitination Negative Regulation Of Cell Cycle Response To Stress
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