UBE3A and SCAMP1

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		UBE3A	SCAMP1
Gene Name		ubiquitin protein ligase E3A	secretory carrier membrane protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Proteasome Complex Nucleus Cytoplasm Cytosol	Trans-Golgi Network Integral Component Of Membrane Clathrin-coated Vesicle Synaptic Vesicle Membrane Zymogen Granule Membrane Recycling Endosome Membrane
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity	Protein Binding Protein Domain Specific Binding
	Biological Process	Ovarian Follicle Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Brain Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Androgen Receptor Signaling Pathway Sperm Entry Regulation Of Circadian Rhythm Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autoubiquitination Prostate Gland Growth Protein K48-linked Ubiquitination Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Exocytosis Post-Golgi Vesicle-mediated Transport Endocytosis Protein Transport
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Cardiac hypertrophy ( 21348951) Obesity-related traits ( 23251661)	Hippocampal atrophy ( 19668339)
Protein-Protein Interactions		80 interactors: ADRM1 AFG3L1P AFTPH AHSP ANXA1 APP AR ARC ASAP3 ATG9A BARD1 BLK BPY2 BPY2B BPY2C BRCA1 C11orf49 CDKN1B CEBPZ DLG1 EAPP EID1 EIF4G1 HBA1 HPCAL4 HSPA4 JADE1 KLHL38 LCK MAGEA8 MCM7 MDM2 MEOX2 NDUFA13 NELFCD NOMO2 PARVA PDE1B PGR PML POLE4 PRDX1 PSAP PSMC3 PSMD4 RAD23A RAD23B RARA RMI1 RNF2 SACS SCAMP1 SCRIB SGK223 SHBG SMAD9 SOD1 SUMO3 TAT TBC1D14 TCF19 TP53 TRIM65 TSC2 TTC3 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBQLN2 UCHL5 YOD1 YWHAE YWHAZ	13 interactors: EGFR EPS15 FAM208B ITSN1 KRTAP13-1 SCAMP2 SLC9A7 SNAP23 SNAP25 SYNRG TP53 UBE3A ZMIZ2
Entrez ID		7337	9522
HPRD ID		03375	06072
Ensembl ID		ENSG00000114062	ENSG00000085365
Uniprot IDs		Q05086 Q9BUI6 Q9H2G0	O15126
PDB IDs		1C4Z 1D5F 1EQX 2KR1 4GIZ
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Protein Catabolic Process Response To Stress Cellular Response To Organic Substance Regulation Of Mitotic Cell Cycle Phase Transition Protein Modification By Small Protein Conjugation Negative Regulation Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Response To Organic Substance Cellular Macromolecule Catabolic Process Positive Regulation Of Cellular Metabolic Process Protein Ubiquitination Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic Cell Cycle Checkpoint Cell Death Death Cell Cycle Checkpoint DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Apoptotic Process Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of G1/S Transition Of Mitotic Cell Cycle Signal Transduction Involved In DNA Damage Checkpoint Regulation Of Cell Cycle G1/S Phase Transition Signal Transduction In Response To DNA Damage Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Cell Cycle Arrest Programmed Cell Death Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Catalytic Activity Proteasomal Protein Catabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein K48-linked Ubiquitination Regulation Of Cell Cycle Catabolic Process Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint	Vesicle-mediated Transport Cellular Localization Synaptic Vesicle Priming Establishment Of Localization In Cell Post-Golgi Vesicle-mediated Transport Synaptic Vesicle Fusion To Presynaptic Membrane Synaptic Vesicle Transport Establishment Of Protein Localization Membrane Organization Transport Protein Localization Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Endocytosis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Golgi Vesicle Transport Negative Regulation Of ERBB Signaling Pathway Protein Transport Vesicle Fusion Cellular Response To Drug Synaptic Vesicle Exocytosis Rhythmic Process Positive Regulation Of Intracellular Signal Transduction Intracellular Transport Establishment Of Organelle Localization Cellular Protein Complex Assembly Alkanesulfonate Metabolic Process Sperm Entry Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Organelle Fusion Positive Regulation Of Protein Kinase B Signaling Regulation Of ERBB Signaling Pathway Response To Osmotic Stress Positive Regulation Of Reactive Oxygen Species Metabolic Process Organelle Localization Regulation Of Fibroblast Proliferation Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Complex Assembly Regulation Of Circadian Rhythm Negative Regulation Of Macromitophagy Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Oligodendrocyte Apoptotic Process Astrocyte Activation Neurotransmitter Secretion Positive Regulation Of Synaptic Transmission Regulation Of Signaling Ovulation Cycle Negative Regulation Of Helicase Activity
Tagcloud ?		2h5 accompanies anova dynactin gadd45a gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube2d3 ubea5 ubiquinase	adaptins adaptor ap1 arabidopsis compartment dihydrophobic dileucine ekqtll export golgi indispensible inositol interacted localize motif prevacuolar relocation rerouted separated subcellular terminus tgn thaliana tonoplast transported transporter1 vacuolar vacuole vit1
Tagcloud (Difference) ?		2h5 accompanies anova dynactin gadd45a gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube2d3 ubea5 ubiquinase	adaptins adaptor ap1 arabidopsis compartment dihydrophobic dileucine ekqtll export golgi indispensible inositol interacted localize motif prevacuolar relocation rerouted separated subcellular terminus tgn thaliana tonoplast transported transporter1 vacuolar vacuole vit1
Tagcloud (Intersection) ?