UBE3A and ALDH1A2

Number of citations of the paper that reports this interaction (PubMedID 32545848)
54

Data Source:
BioGRID (two hybrid, affinity chromatography technology, enzymatic study)

		UBE3A	ALDH1A2
Description		ubiquitin protein ligase E3A	aldehyde dehydrogenase 1 family member A2
Image
GO Annotations	Cellular Component	Proteasome Complex Nucleus Cytoplasm Cytosol Synaptic Vesicle Glutamatergic Synapse Postsynaptic Cytosol	Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Retinal Dehydrogenase (NAD+) Activity 3-chloroallyl Aldehyde Dehydrogenase Activity Aldehyde Dehydrogenase (NAD+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Retinal Binding
	Biological Process	Protein Polyubiquitination Ovarian Follicle Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Brain Development Positive Regulation Of Macromolecule Metabolic Process Protein Ubiquitination Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Cellular Response To Nutrient Levels Response To Progesterone Sperm Entry Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Rhythmic Process Animal Organ Development System Development Modulation Of Chemical Synaptic Transmission Progesterone Receptor Signaling Pathway Protein Autoubiquitination Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Prostate Gland Growth Protein K48-linked Ubiquitination Regulation Of Primary Metabolic Process Positive Regulation Of Protein Localization To Lysosome Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Golgi Lumen Acidification Regulation Of Ubiquitin-dependent Protein Catabolic Process	Blood Vessel Development Kidney Development Liver Development Retinoic Acid Biosynthetic Process Heart Morphogenesis Aldehyde Metabolic Process Lipid Metabolic Process Vitamin A Metabolic Process Midgut Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Determination Of Bilateral Symmetry Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Positive Regulation Of Gene Expression Neural Crest Cell Development Morphogenesis Of Embryonic Epithelium Neural Tube Development Pituitary Gland Development Neuron Differentiation Lung Development Embryonic Limb Morphogenesis Forebrain Development Hindbrain Development Pancreas Development Embryonic Camera-type Eye Development Response To Estradiol Response To Retinoic Acid Response To Vitamin A Response To Cytokine Embryonic Forelimb Morphogenesis Ureter Maturation Retinol Metabolic Process Retinoic Acid Metabolic Process Retinal Metabolic Process 9-cis-retinoic Acid Biosynthetic Process Camera-type Eye Development Positive Regulation Of Apoptotic Process Retinoic Acid Receptor Signaling Pathway Embryonic Digestive Tract Development Cardiac Muscle Tissue Development Protein Homotetramerization Face Development Cellular Response To Retinoic Acid Regulation Of Vascular Endothelial Cell Proliferation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	RA biosynthesis pathway
Drugs			NADH Vitamin A Tretinoin
Diseases		Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS		Cardiac hypertrophy ( 21348951) Gene methylation in lung tissue ( 25713168) Obesity-related traits ( 23251661)	Barrett's esophagus ( 27527254) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Brain morphology (MOSTest) ( 32665545) Cholesterol ( 31902109) Diisocyanate-induced asthma ( 25918132) Eosinophil count ( 32888494) HDL cholesterol ( 30275531 28270201) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hypertension ( 19609347) Ischemic stroke ( 26089329) LDL cholesterol ( 30275531) Lipoprotein (a) levels ( 33730874) Low density lipoprotein cholesterol levels ( 32154731) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Low HDL-cholesterol levels ( 31910446) Lymphocyte count ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Osteoarthritis (hand, severe) ( 24728293) Red blood cell count ( 32888494) Serum metabolite levels ( 33031748) Small cell lung carcinoma ( 28604730) Stroke ( 26089329) Total cholesterol levels ( 30275531) Total cholesterol levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Triglyceride levels ( 32154731) Uncontrolled blood pressure in combination therapy (beta blocker and thiazide diuretic) ( 29097388)
Interacting Genes		165 interacting genes: ACTA2 ACTB ACTBL2 ACTR3 ADRM1 AFG3L1P AFTPH AHSP ALDH1A2 ANXA1 APP AR ARC ARHGDIB ASAP3 ATG9A BAK1 BARD1 BLK BPY2 BPY2B BPY2C BRCA1 CALR CAPN3 CDK1 CDK4 CDKN1B CEBPZ CGGBP1 CKB CRP CSTPP1 CTNNB1 DAZAP2 DDI2 DLG1 DLG4 E2F1 EAPP EEF1A2 EID1 EIF4G1 EML1 ENO1 ENO2 ESR1 FAF2 GFAP GOPC GTF3C1 HBA1 HPCAL4 HSP90AB1 HSPA2 HSPA4 HSPA5 IL24 JADE1 KLHL38 KRT1 KRT5 KRT7 KRT9 LCK LCN2 MAGEA12 MAGEA8 MAPK1 MAPK10 MARF1 MCM2 MCM4 MCM6 MCM7 MDM1 MDM2 MDM4 MEOX2 MSTO1 MYCBP MYCN NBPF14 NDUFA13 NELFCD NFX1 NHERF1 NOMO2 NR3C1 NR4A3 NUMBL PAICS PARVA PAX5 PAX6 PBRM1 PDE1B PDIA3 PDIA6 PGK1 PGR PKM PML POLE4 PPIA PPP1R3F PRAG1 PRDX1 PRKACA PRMT5 PRSS1 PSAP PTCD3 RAD23A RAD23B RARA RMI1 RNF152 RNF2 RPS15A RYBP SACS SCAMP1 SCRIB SERPINB2 SET SHBG SIPA1L1 SIRT6 SMAD9 SNAPC3 SOD1 SPINK1 SUMO3 TALDO1 TAT TBC1D14 TCF19 TMEM14B TP53 TP53BP2 TRIM65 TSC2 TTC23L TTC3 TUBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBE2N UBQLN2 UBR5 WBP2 WDR4 YOD1 YWHAE YWHAG ZNF250 ZNF446	3 interacting genes: HTRA2 OGT UBE3A
Entrez ID		7337	8854
HPRD ID		03375	04733
Ensembl ID		ENSG00000114062	ENSG00000128918
Uniprot IDs		A0A6Q8PHE5 Q05086 Q9H2G0	O94788
PDB IDs		1C4Z 1D5F 1EQX 2KR1 4GIZ 4XR8 6SJV 6SLM 6TGK 6U19 7Q41 7QPB 8ENP 8EPT 8GCR 8JRN 8JRO 8JRP 8JRQ 8JRR 8R1F 8R1G 9CHT	4X2Q 6ALJ 6B5G 6B5H 6B5I
Enriched GO Terms of Interacting Partners?		Cytosol Nucleus Cytoplasm Ubiquitin Protein Ligase Binding Cellular Response To Stress Proteolysis Involved In Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Nucleoplasm Regulation Of Cell Cycle Regulation Of Macromolecule Metabolic Process Response To Stress Protein-containing Complex Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Extracellular Exosome Ubiquitin-dependent Protein Catabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Nuclear Receptor-mediated Signaling Pathway Protein Metabolic Process Regulation Of Gene Expression Regulation Of Apoptotic Process Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Post-translational Protein Modification Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Protein Binding Protein Modification By Small Protein Conjugation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Programmed Cell Death Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Ubiquitination Positive Regulation Of Biosynthetic Process Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Macromolecule Metabolic Process Macromolecule Catabolic Process Enzyme Binding Identical Protein Binding Regulation Of DNA-templated Transcription	Positive Regulation Of TOR Signaling Sperm Entry Positive Regulation Of TORC1 Signaling Regulation Of TORC1 Signaling Regulation Of Protein Localization Positive Regulation Of Golgi Lumen Acidification Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Pentacyclic Triterpenoid Metabolic Process Regulation Of TOR Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Proteolysis Mitochondrial Membrane Protein Processing Negative Regulation Of Type 2 Mitophagy Regulation Of Protein Ubiquitination Negative Regulation Of Signal Transduction Rhythmic Process Regulation Of Golgi Lumen Acidification Negative Regulation Of Cell Communication Regulation Of Post-translational Protein Modification Cellular Response To Nutrient Levels Negative Regulation Of Signaling Protein O-acetylglucosaminyltransferase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cellular PH Reduction Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Response To Herbicide Positive Regulation Of Protein Localization To Lysosome Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Protein Maturation Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Proteolysis Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Transcription By Glucose Prostate Gland Growth Mitochondrial Protein Catabolic Process Serine-type Endopeptidase Complex Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand NSL Complex CD40 Receptor Complex Progesterone Receptor Signaling Pathway Ubiquitin Ligase Inhibitor Activity
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