UBE3A and PDE1B

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		UBE3A	PDE1B
Description		ubiquitin protein ligase E3A	phosphodiesterase 1B
Image
GO Annotations	Cellular Component	Proteasome Complex Nucleus Cytoplasm Cytosol Synaptic Vesicle Glutamatergic Synapse Postsynaptic Cytosol	Cytoplasm Cytosol Neuronal Cell Body
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Calmodulin-activated Dual Specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Calmodulin Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity Calmodulin-activated 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Protein Polyubiquitination Ovarian Follicle Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Brain Development Positive Regulation Of Macromolecule Metabolic Process Protein Ubiquitination Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Cellular Response To Nutrient Levels Response To Progesterone Sperm Entry Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Rhythmic Process Animal Organ Development System Development Modulation Of Chemical Synaptic Transmission Progesterone Receptor Signaling Pathway Protein Autoubiquitination Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Prostate Gland Growth Protein K48-linked Ubiquitination Regulation Of Primary Metabolic Process Positive Regulation Of Protein Localization To Lysosome Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Golgi Lumen Acidification Regulation Of Ubiquitin-dependent Protein Catabolic Process	Response To Amphetamine Signal Transduction Locomotory Behavior Visual Learning Monocyte Differentiation Cellular Response To Macrophage Colony-stimulating Factor Stimulus Dopamine Catabolic Process Serotonin Metabolic Process Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Cam-PDE 1 activation cGMP effects G alpha (s) signalling events
Drugs			Caffeine Caffeine Nicardipine Felodipine Papaverine Bepridil S,S-(2-Hydroxyethyl)Thiocysteine Trapidil
Diseases		Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS		Cardiac hypertrophy ( 21348951) Gene methylation in lung tissue ( 25713168) Obesity-related traits ( 23251661)	Post bronchodilator FEV1 in COPD ( 26634245)
Interacting Genes		165 interacting genes: ACTA2 ACTB ACTBL2 ACTR3 ADRM1 AFG3L1P AFTPH AHSP ALDH1A2 ANXA1 APP AR ARC ARHGDIB ASAP3 ATG9A BAK1 BARD1 BLK BPY2 BPY2B BPY2C BRCA1 CALR CAPN3 CDK1 CDK4 CDKN1B CEBPZ CGGBP1 CKB CRP CSTPP1 CTNNB1 DAZAP2 DDI2 DLG1 DLG4 E2F1 EAPP EEF1A2 EID1 EIF4G1 EML1 ENO1 ENO2 ESR1 FAF2 GFAP GOPC GTF3C1 HBA1 HPCAL4 HSP90AB1 HSPA2 HSPA4 HSPA5 IL24 JADE1 KLHL38 KRT1 KRT5 KRT7 KRT9 LCK LCN2 MAGEA12 MAGEA8 MAPK1 MAPK10 MARF1 MCM2 MCM4 MCM6 MCM7 MDM1 MDM2 MDM4 MEOX2 MSTO1 MYCBP MYCN NBPF14 NDUFA13 NELFCD NFX1 NHERF1 NOMO2 NR3C1 NR4A3 NUMBL PAICS PARVA PAX5 PAX6 PBRM1 PDE1B PDIA3 PDIA6 PGK1 PGR PKM PML POLE4 PPIA PPP1R3F PRAG1 PRDX1 PRKACA PRMT5 PRSS1 PSAP PTCD3 RAD23A RAD23B RARA RMI1 RNF152 RNF2 RPS15A RYBP SACS SCAMP1 SCRIB SERPINB2 SET SHBG SIPA1L1 SIRT6 SMAD9 SNAPC3 SOD1 SPINK1 SUMO3 TALDO1 TAT TBC1D14 TCF19 TMEM14B TP53 TP53BP2 TRIM65 TSC2 TTC23L TTC3 TUBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBE2N UBQLN2 UBR5 WBP2 WDR4 YOD1 YWHAE YWHAG ZNF250 ZNF446	2 interacting genes: POT1 UBE3A
Entrez ID		7337	5153
HPRD ID		03375	01388
Ensembl ID		ENSG00000114062	ENSG00000123360
Uniprot IDs		A0A6Q8PHE5 Q05086 Q9H2G0	B3KX78 B4DK72 Q01064
PDB IDs		1C4Z 1D5F 1EQX 2KR1 4GIZ 4XR8 6SJV 6SLM 6TGK 6U19 7Q41 7QPB 8ENP 8EPT 8GCR 8JRN 8JRO 8JRP 8JRQ 8JRR 8R1F 8R1G 9CHT	1TAZ 4NPV 4NPW 5B25 5UOY 5UP0 5W6E
Enriched GO Terms of Interacting Partners?		Cytosol Nucleus Cytoplasm Ubiquitin Protein Ligase Binding Cellular Response To Stress Proteolysis Involved In Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Nucleoplasm Regulation Of Cell Cycle Regulation Of Macromolecule Metabolic Process Response To Stress Protein-containing Complex Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Extracellular Exosome Ubiquitin-dependent Protein Catabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Nuclear Receptor-mediated Signaling Pathway Protein Metabolic Process Regulation Of Gene Expression Regulation Of Apoptotic Process Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Post-translational Protein Modification Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Protein Binding Protein Modification By Small Protein Conjugation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Programmed Cell Death Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Ubiquitination Positive Regulation Of Biosynthetic Process Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Macromolecule Metabolic Process Macromolecule Catabolic Process Enzyme Binding Identical Protein Binding Regulation Of DNA-templated Transcription	Ribonucleotide Binding Sperm Entry Positive Regulation Of Golgi Lumen Acidification Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Regulation Of Golgi Lumen Acidification Positive Regulation Of Telomeric Loop Disassembly 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomeric D-loop Binding Telomere Assembly Alpha DNA Polymerase:primase Complex Positive Regulation Of Cellular PH Reduction Single-stranded Telomeric DNA Binding DNA Replication, Synthesis Of Primer Positive Regulation Of Protein Localization To Lysosome Shelterin Complex Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere DEAD/H-box RNA Helicase Binding Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Prostate Gland Growth G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Progesterone Receptor Signaling Pathway Telomere Capping Regulation Of DNA Strand Elongation Androgen Receptor Signaling Pathway Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase DNA Metabolic Process DNA Replication Initiation DNA-directed RNA Polymerase Activity Postsynaptic Cytosol Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding RNA-templated DNA Biosynthetic Process Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Progesterone DNA-directed RNA Polymerase Complex Negative Regulation Of Telomere Maintenance Nucleobase-containing Compound Biosynthetic Process Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process
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