UBE3A and ACTA2

Number of citations of the paper that reports this interaction (PubMedID 26506232)
49

Data Source:
BioGRID (pull down)

		UBE3A	ACTA2
Description		ubiquitin protein ligase E3A	actin alpha 2, smooth muscle
Image			No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus Cytoplasm Cytosol Synaptic Vesicle Glutamatergic Synapse Postsynaptic Cytosol	Stress Fiber Basement Membrane Extracellular Space Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Lamellipodium Filopodium Smooth Muscle Contractile Fiber Motile Cilium Protein-containing Complex Cell Body Extracellular Exosome
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity Protein Kinase Binding
	Biological Process	Protein Polyubiquitination Ovarian Follicle Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Brain Development Positive Regulation Of Macromolecule Metabolic Process Protein Ubiquitination Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Cellular Response To Nutrient Levels Response To Progesterone Sperm Entry Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Rhythmic Process Animal Organ Development System Development Modulation Of Chemical Synaptic Transmission Progesterone Receptor Signaling Pathway Protein Autoubiquitination Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Prostate Gland Growth Protein K48-linked Ubiquitination Regulation Of Primary Metabolic Process Positive Regulation Of Protein Localization To Lysosome Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Golgi Lumen Acidification Regulation Of Ubiquitin-dependent Protein Catabolic Process	Muscle Contraction Regulation Of Blood Pressure Response To Virus Positive Regulation Of Gene Expression Vascular Associated Smooth Muscle Contraction Positive Regulation Of Hepatic Stellate Cell Migration Positive Regulation Of Hepatic Stellate Cell Contraction Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Transforming Growth Factor Beta Stimulus Juxtaglomerular Apparatus Development Glomerular Mesangial Cell Development Mesenchyme Migration Positive Regulation Of Hepatic Stellate Cell Activation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Smooth Muscle Contraction NOTCH4 Intracellular Domain Regulates Transcription Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Mammary Gland Myoepithelial Cells
Drugs			Phenethyl Isothiocyanate
Diseases		Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)	Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS		Cardiac hypertrophy ( 21348951) Gene methylation in lung tissue ( 25713168) Obesity-related traits ( 23251661)	Arthritis (juvenile idiopathic) ( 33106285) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic lymphocytic leukemia ( 23770605 26956414) Immunoglobulin A ( 20694011) Lymphocyte percentage of white cells ( 32888494) Pulse pressure ( 30578418) Selective IgA deficiency ( 27723758)
Interacting Genes		165 interacting genes: ACTA2 ACTB ACTBL2 ACTR3 ADRM1 AFG3L1P AFTPH AHSP ALDH1A2 ANXA1 APP AR ARC ARHGDIB ASAP3 ATG9A BAK1 BARD1 BLK BPY2 BPY2B BPY2C BRCA1 CALR CAPN3 CDK1 CDK4 CDKN1B CEBPZ CGGBP1 CKB CRP CSTPP1 CTNNB1 DAZAP2 DDI2 DLG1 DLG4 E2F1 EAPP EEF1A2 EID1 EIF4G1 EML1 ENO1 ENO2 ESR1 FAF2 GFAP GOPC GTF3C1 HBA1 HPCAL4 HSP90AB1 HSPA2 HSPA4 HSPA5 IL24 JADE1 KLHL38 KRT1 KRT5 KRT7 KRT9 LCK LCN2 MAGEA12 MAGEA8 MAPK1 MAPK10 MARF1 MCM2 MCM4 MCM6 MCM7 MDM1 MDM2 MDM4 MEOX2 MSTO1 MYCBP MYCN NBPF14 NDUFA13 NELFCD NFX1 NHERF1 NOMO2 NR3C1 NR4A3 NUMBL PAICS PARVA PAX5 PAX6 PBRM1 PDE1B PDIA3 PDIA6 PGK1 PGR PKM PML POLE4 PPIA PPP1R3F PRAG1 PRDX1 PRKACA PRMT5 PRSS1 PSAP PTCD3 RAD23A RAD23B RARA RMI1 RNF152 RNF2 RPS15A RYBP SACS SCAMP1 SCRIB SERPINB2 SET SHBG SIPA1L1 SIRT6 SMAD9 SNAPC3 SOD1 SPINK1 SUMO3 TALDO1 TAT TBC1D14 TCF19 TMEM14B TP53 TP53BP2 TRIM65 TSC2 TTC23L TTC3 TUBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBE2N UBQLN2 UBR5 WBP2 WDR4 YOD1 YWHAE YWHAG ZNF250 ZNF446	18 interacting genes: CCT4 CCT5 CFL1 CREBBP DNASE1 EP300 GC MINK1 MYL1 MYOC PCYT1B PRKCD SELE SHBG SNTA1 TMSB4X UBE3A YBX1
Entrez ID		7337	59
HPRD ID		03375	00031
Ensembl ID		ENSG00000114062	ENSG00000107796
Uniprot IDs		A0A6Q8PHE5 Q05086 Q9H2G0	A0AAQ5BGG7 A0AAQ5BGI6 D2JYH4 P62736
PDB IDs		1C4Z 1D5F 1EQX 2KR1 4GIZ 4XR8 6SJV 6SLM 6TGK 6U19 7Q41 7QPB 8ENP 8EPT 8GCR 8JRN 8JRO 8JRP 8JRQ 8JRR 8R1F 8R1G 9CHT
Enriched GO Terms of Interacting Partners?		Cytosol Nucleus Cytoplasm Ubiquitin Protein Ligase Binding Cellular Response To Stress Proteolysis Involved In Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Nucleoplasm Regulation Of Cell Cycle Regulation Of Macromolecule Metabolic Process Response To Stress Protein-containing Complex Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Extracellular Exosome Ubiquitin-dependent Protein Catabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Nuclear Receptor-mediated Signaling Pathway Protein Metabolic Process Regulation Of Gene Expression Regulation Of Apoptotic Process Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Post-translational Protein Modification Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Protein Binding Protein Modification By Small Protein Conjugation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Programmed Cell Death Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Ubiquitination Positive Regulation Of Biosynthetic Process Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Macromolecule Metabolic Process Macromolecule Catabolic Process Enzyme Binding Identical Protein Binding Regulation Of DNA-templated Transcription	Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization Regulation Of Protein Localization To Nucleus Histone H3K27 Acetyltransferase Activity Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Protein Stabilization Regulation Of Biological Quality Extracellular Exosome Negative Regulation Of Supramolecular Fiber Organization Negative Regulation Of Cytoskeleton Organization Regulation Of Protein Localization Actin Binding Regulation Of Protein Stability Positive Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex N-terminal Protein Amino Acid Acetylation Regulation Of Telomerase RNA Localization To Cajal Body Peptidyl-lysine Acetylation Cellular Response To UV Regulation Of Cell Adhesion Regulation Of Organelle Organization Regulation Of Cellular Response To Heat Regulation Of Actin Filament Organization Regulation Of Defense Response Intracellular Signaling Cassette Acetyltransferase Activity Positive Regulation Of DNA Metabolic Process Cellular Response To Light Stimulus Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of Actin Filament Polymerization Histone Acetyltransferase Complex Regulation Of Cell-matrix Adhesion Protein-lysine-acetyltransferase Activity Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protein-containing Complex Assembly Regulation Of Actin Cytoskeleton Organization Neutrophil Activation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Focal Adhesion Assembly Binding Of Sperm To Zona Pellucida Histone Acetyltransferase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Acetylation
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