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HUWE1 and PIAS2
Number of citations of the paper that reports this interaction (PubMedID
20624960
)
53
Data Source:
BioGRID
(enzymatic study, affinity chromatography technology)
HUWE1
PIAS2
Description
HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
protein inhibitor of activated STAT 2
Image
GO Annotations
Cellular Component
Golgi Membrane
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Membrane
Secretory Granule Lumen
Extracellular Exosome
Ficolin-1-rich Granule Lumen
Chromatin
Nucleus
Nucleoplasm
PML Body
Nuclear Speck
Molecular Function
DNA Binding
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Transferase Activity
Ubiquitin-ubiquitin Ligase Activity
Ubiquitin Protein Ligase Activity
Histone Ubiquitin Ligase Activity
DNA Binding
Transcription Coregulator Activity
Transcription Corepressor Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
SUMO Transferase Activity
Ubiquitin Protein Ligase Binding
Metal Ion Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
SUMO Ligase Activity
Biological Process
Protein Polyubiquitination
DNA Repair
Base-excision Repair
Chromatin Remodeling
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
DNA Damage Response
Golgi Organization
Canonical NF-kappaB Signal Transduction
Negative Regulation Of Mitochondrial Fusion
Protein Ubiquitination
Cell Differentiation
Positive Regulation Of Protein Ubiquitination
Circadian Regulation Of Gene Expression
Peroxisome Proliferator Activated Receptor Signaling Pathway
Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway
Defense Response To Bacterium
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Rhythmic Process
Membrane Fusion
Protein K48-linked Ubiquitination
Protein Branched Polyubiquitination
Positive Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Type 2 Mitophagy
DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transforming Growth Factor Beta Receptor Signaling Pathway
Protein Sumoylation
Endoplasmic Reticulum Unfolded Protein Response
Negative Regulation Of DNA-templated Transcription
Regulation Of Macromolecule Metabolic Process
SMAD Protein Signal Transduction
Negative Regulation Of Androgen Receptor Signaling Pathway
Pathways
Neutrophil degranulation
Antigen processing: Ubiquitination & Proteasome degradation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS
Bipolar disorder (
31043756
)
Body mass index (
28892062
)
Educational attainment (years of education) (
30038396
)
Fruit consumption (
32066663
)
Interacting Genes
41 interacting genes:
ABL1
ATOH1
CALM1
CASP1
CCL1
CD274
CDKN2A
CLIC6
CREBBP
CUL4B
DDIT4
ERG
H2AX
H2BC3
LAPTM5
MCL1
MYCN
NRIP1
PCNT
PIAS2
POLB
POLL
PPP5C
PTOV1
RNF10
RNF11
SMAD2
SMAD9
SUMO2
TBP
TNS2
TP53
UBA6
UBC
UBE2D1
UBE2D2
UBE2G1
UBE2L3
UBE2Z
WBP2
WIPI2
128 interacting genes:
-
ACY3
ADA
AKT1
AR
ATF2
C1QA
C5orf24
CBS
CCHCR1
CCNDBP1
CDCA8
CGGBP1
CHMP4B
CLDN2
CREB1
CREBBP
CTBP1
DDX39B
DES
DEUP1
DMC1
DNMT3A
EDC3
ELK1
ESR1
ESR2
EXOSC8
FAM118B
FKBP6
FLI1
GFAP
GLUL
GOLGA2
GRHL2
GRM8
GTF2I
GTF2IRD1
HDAC3
HMBOX1
HMG20A
HMG20B
HMGXB4
HNRNPCL1
HNRNPUL1
HOMER1
HOOK1
HUWE1
IKZF1
IMPDH1
JUN
KIFC3
LCE1E
LCE2C
LMNA
LMNB1
MAPK14
MAPK8
MAPKAPK2
MBD1
MITF
MLX
MSX2
MX1
MX2
NAV2
NME7
NR3C1
PAICS
PARK7
PAXIP1
PGR
PHC1
PIAS1
PIAS4
PLAG1
PLAGL1
PML
PRKAB2
PRKRA
PRPH
RFX2
RUFY1
RUNX1T1
SEC23A
SIAH1
SIAH2
SMAD3
SMAD4
SNAI2
SNIP1
SOX5
SPATC1L
SPINDOC
SREBF2
STAT1
STAT4
STIP1
SUMO1
SUMO1P1
SUMO2
SUMO3
SYN3
TH
TICAM2
TP53
TRAF2
TRAF3
TRAF5
TRIM23
TRIM27
TRIM50
TRIM55
TRIM63
TSR2
TXLNA
UBASH3B
UBE2I
UBE2L3
UBQLN1
ZBED1
ZBTB16
ZBTB8A
ZC3H10
ZFP42
ZNF319
ZNF451
ZNRD2
Entrez ID
10075
9063
HPRD ID
06608
06944
Ensembl ID
ENSG00000086758
ENSG00000078043
Uniprot IDs
Q7Z6Z7
O75928
Q2TA77
PDB IDs
2EKK
2MUL
3G1N
3H1D
5C6H
5LP8
6FYH
6MIW
6PFL
7AZX
7JQ9
7MOP
7MWD
7MWE
7MWF
8R7O
8RD0
8RD1
8RD7
2ASQ
4FO9
Enriched GO Terms of Interacting Partners
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Post-translational Protein Modification
Protein Modification Process
Nucleoplasm
Protein Modification By Small Protein Conjugation
Protein-containing Complex
Protein Ubiquitination
Ubiquitin Conjugating Enzyme Activity
Ubiquitin Protein Ligase Binding
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Nucleus
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Intracellular Signal Transduction
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Macromolecule Metabolic Process
Positive Regulation Of Biosynthetic Process
Modification-dependent Protein Catabolic Process
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Cellular Response To Stress
DNA Damage Response
Protein Metabolic Process
Negative Regulation Of Gliogenesis
Intrinsic Apoptotic Signaling Pathway
Macromolecule Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Enzyme Binding
Protein Polyubiquitination
Regulation Of Transcription By RNA Polymerase II
Chromatin
Ubiquitin-dependent Protein Catabolic Process
Cytosol
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Apoptotic Signaling Pathway
DNA Binding
SUMO Transferase Activity
Double-strand Break Repair
Damaged DNA Binding
Signal Transduction
Catabolic Process
DNA Repair
SMAD Protein Signal Transduction
Disordered Domain Specific Binding
Regulation Of RNA Metabolic Process
Identical Protein Binding
Nucleus
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Enzyme Binding
Negative Regulation Of Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
DNA Binding
Negative Regulation Of RNA Biosynthetic Process
PML Body
Protein Sumoylation
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Nucleoplasm
Regulation Of RNA Metabolic Process
DNA-binding Transcription Factor Activity
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Transcription By RNA Polymerase II
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Chromatin
Protein Binding
Regulation Of Primary Metabolic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of DNA-templated Transcription
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
SUMO Transferase Activity
Positive Regulation Of Transcription By RNA Polymerase II
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Zinc Ion Binding
Positive Regulation Of Biosynthetic Process
Cytoplasm
Positive Regulation Of Macromolecule Metabolic Process
Protein Modification By Small Protein Conjugation
Ubiquitin Protein Ligase Binding
Estrogen Response Element Binding
Sequence-specific DNA Binding
Positive Regulation Of Metabolic Process
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