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HUWE1
Description
HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
Image
GO Annotations
Cellular Component
Golgi Membrane
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Membrane
Secretory Granule Lumen
Extracellular Exosome
Ficolin-1-rich Granule Lumen
Molecular Function
DNA Binding
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Transferase Activity
Ubiquitin-ubiquitin Ligase Activity
Ubiquitin Protein Ligase Activity
Histone Ubiquitin Ligase Activity
Biological Process
Protein Polyubiquitination
DNA Repair
Base-excision Repair
Chromatin Remodeling
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
DNA Damage Response
Golgi Organization
Canonical NF-kappaB Signal Transduction
Negative Regulation Of Mitochondrial Fusion
Protein Ubiquitination
Cell Differentiation
Positive Regulation Of Protein Ubiquitination
Circadian Regulation Of Gene Expression
Peroxisome Proliferator Activated Receptor Signaling Pathway
Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway
Defense Response To Bacterium
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Rhythmic Process
Membrane Fusion
Protein K48-linked Ubiquitination
Protein Branched Polyubiquitination
Positive Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Type 2 Mitophagy
Pathways
Neutrophil degranulation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS
Bipolar disorder (
31043756
)
Body mass index (
28892062
)
Educational attainment (years of education) (
30038396
)
Interacting Genes
41 interacting genes:
ABL1
ATOH1
CALM1
CASP1
CCL1
CD274
CDKN2A
CLIC6
CREBBP
CUL4B
DDIT4
ERG
H2AX
H2BC3
LAPTM5
MCL1
MYCN
NRIP1
PCNT
PIAS2
POLB
POLL
PPP5C
PTOV1
RNF10
RNF11
SMAD2
SMAD9
SUMO2
TBP
TNS2
TP53
UBA6
UBC
UBE2D1
UBE2D2
UBE2G1
UBE2L3
UBE2Z
WBP2
WIPI2
Entrez ID
10075
HPRD ID
06608
Ensembl ID
ENSG00000086758
Uniprot IDs
Q7Z6Z7
PDB IDs
2EKK
2MUL
3G1N
3H1D
5C6H
5LP8
6FYH
6MIW
6PFL
7AZX
7JQ9
7MOP
7MWD
7MWE
7MWF
8R7O
8RD0
8RD1
8RD7
Enriched GO Terms of Interacting Partners
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Post-translational Protein Modification
Protein Modification Process
Nucleoplasm
Protein Modification By Small Protein Conjugation
Protein-containing Complex
Protein Ubiquitination
Ubiquitin Conjugating Enzyme Activity
Ubiquitin Protein Ligase Binding
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Nucleus
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Intracellular Signal Transduction
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Macromolecule Metabolic Process
Positive Regulation Of Biosynthetic Process
Modification-dependent Protein Catabolic Process
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Cellular Response To Stress
DNA Damage Response
Protein Metabolic Process
Negative Regulation Of Gliogenesis
Intrinsic Apoptotic Signaling Pathway
Macromolecule Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Enzyme Binding
Protein Polyubiquitination
Regulation Of Transcription By RNA Polymerase II
Chromatin
Ubiquitin-dependent Protein Catabolic Process
Cytosol
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Apoptotic Signaling Pathway
DNA Binding
SUMO Transferase Activity
Double-strand Break Repair
Damaged DNA Binding
Signal Transduction
Catabolic Process
DNA Repair
SMAD Protein Signal Transduction
Disordered Domain Specific Binding
Regulation Of RNA Metabolic Process
Tagcloud
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