HUWE1 and DDIT4

Number of citations of the paper that reports this interaction (PubMedID 34314700)
76

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down)

		HUWE1	DDIT4
Description		HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1	DNA damage inducible transcript 4
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Cytoplasm Mitochondrion Cytosol
	Molecular Function	DNA Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity Histone Ubiquitin Ligase Activity	Protein Binding 14-3-3 Protein Binding
	Biological Process	Protein Polyubiquitination DNA Repair Base-excision Repair Chromatin Remodeling Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination DNA Damage Response Golgi Organization Canonical NF-kappaB Signal Transduction Negative Regulation Of Mitochondrial Fusion Protein Ubiquitination Cell Differentiation Positive Regulation Of Protein Ubiquitination Circadian Regulation Of Gene Expression Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Rhythmic Process Membrane Fusion Protein K48-linked Ubiquitination Protein Branched Polyubiquitination Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Type 2 Mitophagy	Response To Hypoxia Neuron Migration Apoptotic Process Brain Development Negative Regulation Of Signal Transduction Neuron Differentiation Negative Regulation Of TOR Signaling Protein-containing Complex Disassembly Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Glycolytic Process Neurotrophin TRK Receptor Signaling Pathway Defense Response To Virus Cellular Response To Dexamethasone Stimulus Reactive Oxygen Species Metabolic Process
Pathways		Neutrophil degranulation Antigen processing: Ubiquitination & Proteasome degradation	TP53 Regulates Metabolic Genes
Drugs
Diseases		Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Bipolar disorder ( 31043756) Body mass index ( 28892062) Educational attainment (years of education) ( 30038396)	Blond vs. brown/black hair color ( 30531825) Body mass index ( 31513605) Heschl's gyrus morphology ( 25130324) Refractive error ( 32231278)
Interacting Genes		41 interacting genes: ABL1 ATOH1 CALM1 CASP1 CCL1 CD274 CDKN2A CLIC6 CREBBP CUL4B DDIT4 ERG H2AX H2BC3 LAPTM5 MCL1 MYCN NRIP1 PCNT PIAS2 POLB POLL PPP5C PTOV1 RNF10 RNF11 SMAD2 SMAD9 SUMO2 TBP TNS2 TP53 UBA6 UBC UBE2D1 UBE2D2 UBE2G1 UBE2L3 UBE2Z WBP2 WIPI2	8 interacting genes: GSK3B HSPA4 HSPB2 HUWE1 LRIF1 LRRK2 PDPK1 TXNIP
Entrez ID		10075	54541
HPRD ID		06608	09662
Ensembl ID		ENSG00000086758	ENSG00000168209
Uniprot IDs		Q7Z6Z7	Q9NX09
PDB IDs		2EKK 2MUL 3G1N 3H1D 5C6H 5LP8 6FYH 6MIW 6PFL 7AZX 7JQ9 7MOP 7MWD 7MWE 7MWF 8R7O 8RD0 8RD1 8RD7	3LQ9 7MOP
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification Process Nucleoplasm Protein Modification By Small Protein Conjugation Protein-containing Complex Protein Ubiquitination Ubiquitin Conjugating Enzyme Activity Ubiquitin Protein Ligase Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Nucleus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Modification-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Stress DNA Damage Response Protein Metabolic Process Negative Regulation Of Gliogenesis Intrinsic Apoptotic Signaling Pathway Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Enzyme Binding Protein Polyubiquitination Regulation Of Transcription By RNA Polymerase II Chromatin Ubiquitin-dependent Protein Catabolic Process Cytosol RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Apoptotic Signaling Pathway DNA Binding SUMO Transferase Activity Double-strand Break Repair Damaged DNA Binding Signal Transduction Catabolic Process DNA Repair SMAD Protein Signal Transduction Disordered Domain Specific Binding Regulation Of RNA Metabolic Process	Positive Regulation Of Post-translational Protein Modification Wnt Signalosome Protein Autophosphorylation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Positive Regulation Of Protein Ubiquitination Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Stress Positive Regulation Of Autophagy Positive Regulation Of Mitochondrial Membrane Permeability Regulation Of Protein Ubiquitination Positive Regulation Of Membrane Permeability Regulation Of Post-translational Protein Modification Protein Localization To Mitochondrion Regulation Of Apoptotic Process Regulation Of Protein Targeting To Mitochondrion Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Membrane Permeability Protein Serine Kinase Activity Intracellular Signaling Cassette Protein Phosphorylation Regulation Of Anatomical Structure Morphogenesis Regulation Of Protein Localization Regulation Of Microtubule Anchoring At Centrosome Regulation Of Mitochondrial Membrane Permeability Excitatory Postsynaptic Potential Negative Regulation Of Programmed Cell Death Establishment Of Protein Localization To Organelle 3-phosphoinositide-dependent Protein Kinase Activity Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Regulation Of Autophagy Positive Regulation Of Protein Modification Process Phosphorylation Insulin Receptor Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Serine/threonine Kinase Activity Superior Temporal Gyrus Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Development Canonical Wnt Signaling Pathway Regulation Of Postsynaptic Membrane Potential Negative Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Calcium-mediated Signaling Negative Regulation Of Glycogen (starch) Synthase Activity Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Unfolded Protein
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