HUWE1 and CCL1

Number of citations of the paper that reports this interaction (PubMedID 15989956)
0

Data Source:
HPRD (in vitro)

		HUWE1	CCL1
Description		HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1	C-C motif chemokine ligand 1
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space
	Molecular Function	DNA Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity Histone Ubiquitin Ligase Activity	Cytokine Activity Chemokine Activity CCR Chemokine Receptor Binding
	Biological Process	Protein Polyubiquitination DNA Repair Base-excision Repair Chromatin Remodeling Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination DNA Damage Response Golgi Organization Canonical NF-kappaB Signal Transduction Negative Regulation Of Mitochondrial Fusion Protein Ubiquitination Cell Differentiation Positive Regulation Of Protein Ubiquitination Circadian Regulation Of Gene Expression Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Rhythmic Process Membrane Fusion Protein K48-linked Ubiquitination Protein Branched Polyubiquitination Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Type 2 Mitophagy	Intracellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Viral Process Positive Regulation Of Cell Migration Killing Of Cells Of Another Organism Positive Regulation Of Interleukin-17 Production Eosinophil Chemotaxis Positive Regulation Of Inflammatory Response Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Positive Regulation Of Monocyte Chemotaxis
Pathways		Neutrophil degranulation Antigen processing: Ubiquitination & Proteasome degradation	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases		Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Bipolar disorder ( 31043756) Body mass index ( 28892062) Educational attainment (years of education) ( 30038396)	Crohn's disease ( 22412388)
Interacting Genes		41 interacting genes: ABL1 ATOH1 CALM1 CASP1 CCL1 CD274 CDKN2A CLIC6 CREBBP CUL4B DDIT4 ERG H2AX H2BC3 LAPTM5 MCL1 MYCN NRIP1 PCNT PIAS2 POLB POLL PPP5C PTOV1 RNF10 RNF11 SMAD2 SMAD9 SUMO2 TBP TNS2 TP53 UBA6 UBC UBE2D1 UBE2D2 UBE2G1 UBE2L3 UBE2Z WBP2 WIPI2	3 interacting genes: CCR8 CXCL11 HUWE1
Entrez ID		10075	6346
HPRD ID		06608	01654
Ensembl ID		ENSG00000086758	ENSG00000108702
Uniprot IDs		Q7Z6Z7	P22362
PDB IDs		2EKK 2MUL 3G1N 3H1D 5C6H 5LP8 6FYH 6MIW 6PFL 7AZX 7JQ9 7MOP 7MWD 7MWE 7MWF 8R7O 8RD0 8RD1 8RD7	1EL0 4OIJ 4OIK 8U1U
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification Process Nucleoplasm Protein Modification By Small Protein Conjugation Protein-containing Complex Protein Ubiquitination Ubiquitin Conjugating Enzyme Activity Ubiquitin Protein Ligase Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Nucleus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Modification-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Stress DNA Damage Response Protein Metabolic Process Negative Regulation Of Gliogenesis Intrinsic Apoptotic Signaling Pathway Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Enzyme Binding Protein Polyubiquitination Regulation Of Transcription By RNA Polymerase II Chromatin Ubiquitin-dependent Protein Catabolic Process Cytosol RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Apoptotic Signaling Pathway DNA Binding SUMO Transferase Activity Double-strand Break Repair Damaged DNA Binding Signal Transduction Catabolic Process DNA Repair SMAD Protein Signal Transduction Disordered Domain Specific Binding Regulation Of RNA Metabolic Process	Chemokine-mediated Signaling Pathway Locomotion Cell Chemotaxis Chemotaxis CXCR3 Chemokine Receptor Binding Histone Ubiquitin Ligase Activity Negative Regulation Of Mitochondrial Fusion Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Mitochondrial Fusion Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of Type 2 Mitophagy T Cell Chemotaxis Ubiquitin-ubiquitin Ligase Activity Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Lymphocyte Chemotaxis Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of Mitophagy Protein Branched Polyubiquitination Positive Regulation Of Autophagy Of Mitochondrion
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