HUWE1 and PTOV1

Number of citations of the paper that reports this interaction (PubMedID 34654719)
60

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		HUWE1	PTOV1
Description		HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1	PTOV1 extended AT-hook containing adaptor protein
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Plasma Membrane Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity Histone Ubiquitin Ligase Activity
	Biological Process	Protein Polyubiquitination DNA Repair Base-excision Repair Chromatin Remodeling Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination DNA Damage Response Golgi Organization Canonical NF-kappaB Signal Transduction Negative Regulation Of Mitochondrial Fusion Protein Ubiquitination Cell Differentiation Positive Regulation Of Protein Ubiquitination Circadian Regulation Of Gene Expression Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Rhythmic Process Membrane Fusion Protein K48-linked Ubiquitination Protein Branched Polyubiquitination Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Type 2 Mitophagy	Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Neutrophil degranulation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Bipolar disorder ( 31043756) Body mass index ( 28892062) Educational attainment (years of education) ( 30038396)
Interacting Genes		41 interacting genes: ABL1 ATOH1 CALM1 CASP1 CCL1 CD274 CDKN2A CLIC6 CREBBP CUL4B DDIT4 ERG H2AX H2BC3 LAPTM5 MCL1 MYCN NRIP1 PCNT PIAS2 POLB POLL PPP5C PTOV1 RNF10 RNF11 SMAD2 SMAD9 SUMO2 TBP TNS2 TP53 UBA6 UBC UBE2D1 UBE2D2 UBE2G1 UBE2L3 UBE2Z WBP2 WIPI2	18 interacting genes: CCR4 DMTN DYRK1A HDAC1 HDAC4 HDAC6 HUWE1 NCOR1 PBK PIN1 PRKCD RACK1 RBPJ SGK2 SPTAN1 TMCC2 UBC USP16
Entrez ID		10075	53635
HPRD ID		06608	17929
Ensembl ID		ENSG00000086758	ENSG00000104960
Uniprot IDs		Q7Z6Z7	A0A0C4DGR2 M0QY25 Q86YD1
PDB IDs		2EKK 2MUL 3G1N 3H1D 5C6H 5LP8 6FYH 6MIW 6PFL 7AZX 7JQ9 7MOP 7MWD 7MWE 7MWF 8R7O 8RD0 8RD1 8RD7
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification Process Nucleoplasm Protein Modification By Small Protein Conjugation Protein-containing Complex Protein Ubiquitination Ubiquitin Conjugating Enzyme Activity Ubiquitin Protein Ligase Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Nucleus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Modification-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Stress DNA Damage Response Protein Metabolic Process Negative Regulation Of Gliogenesis Intrinsic Apoptotic Signaling Pathway Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Enzyme Binding Protein Polyubiquitination Regulation Of Transcription By RNA Polymerase II Chromatin Ubiquitin-dependent Protein Catabolic Process Cytosol RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Apoptotic Signaling Pathway DNA Binding SUMO Transferase Activity Double-strand Break Repair Damaged DNA Binding Signal Transduction Catabolic Process DNA Repair SMAD Protein Signal Transduction Disordered Domain Specific Binding Regulation Of RNA Metabolic Process	Protein Modification Process Histone Deacetylase Complex Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Protein-containing Complex Assembly Protein Deacetylation Protein Lysine Deacetylase Activity Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Negative Regulation Of Intracellular Signal Transduction Protein Metabolic Process Transcription Repressor Complex Histone Deacetylase Activity Macromolecule Deacylation Regulation Of Protein-containing Complex Assembly Negative Regulation Of Cellular Component Organization Rhythmic Process Regulation Of Androgen Receptor Signaling Pathway Regulation Of Protein Metabolic Process Histone Deacetylase Binding Circadian Rhythm Nucleoplasm Tau Protein Binding Chromatin Organization Post-translational Protein Modification Regulation Of Phosphorus Metabolic Process Negative Regulation Of Actin Filament Polymerization Negative Regulation Of MAPK Cascade Negative Regulation Of Catabolic Process Regulation Of Supramolecular Fiber Organization Chromatin Remodeling Negative Regulation Of Signal Transduction RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Type 2 Mitophagy Regulation Of Translational Elongation Response To Stress Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Protein-containing Complex Disassembly Negative Regulation Of Macromolecule Metabolic Process Regulation Of Amide Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Protein Depolymerization Regulation Of Organelle Organization Macromolecule Metabolic Process Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Myotube Differentiation
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