HUWE1 and MCL1

Number of citations of the paper that reports this interaction (PubMedID 37167062)
79

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		HUWE1	MCL1
Description		HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1	MCL1 apoptosis regulator, BCL2 family member
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Bcl-2 Family Protein Complex
	Molecular Function	DNA Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity Histone Ubiquitin Ligase Activity	Protein Binding Protein Transmembrane Transporter Activity Channel Activity Protein Heterodimerization Activity BH Domain Binding BH3 Domain Binding
	Biological Process	Protein Polyubiquitination DNA Repair Base-excision Repair Chromatin Remodeling Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination DNA Damage Response Golgi Organization Canonical NF-kappaB Signal Transduction Negative Regulation Of Mitochondrial Fusion Protein Ubiquitination Cell Differentiation Positive Regulation Of Protein Ubiquitination Circadian Regulation Of Gene Expression Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Rhythmic Process Membrane Fusion Protein K48-linked Ubiquitination Protein Branched Polyubiquitination Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Type 2 Mitophagy	Cell Fate Determination Release Of Cytochrome C From Mitochondria Apoptotic Process DNA Damage Response Mitochondrial Fusion Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Autophagy Cellular Homeostasis Cell Differentiation Response To Cytokine Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Transmembrane Transport Protein Transmembrane Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Intracellular Signal Transduction Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Anoikis Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Neutrophil degranulation Antigen processing: Ubiquitination & Proteasome degradation	Interleukin-4 and Interleukin-13 signaling Signaling by ALK fusions and activated point mutants
Drugs
Diseases		Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Bipolar disorder ( 31043756) Body mass index ( 28892062) Educational attainment (years of education) ( 30038396)	Blood protein levels ( 30072576) Coffee consumption ( 31959922) Coronary artery disease ( 29212778) Eosinophil count ( 27863252) FEV1 ( 30804560) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082 30804560) Mean corpuscular hemoglobin ( 32888494) Melanoma ( 21983785) Monocyte count ( 29403010) Multiple sclerosis ( 31604244) Refractive error ( 32231278) Rhegmatogenous retinal detachment ( 23585552) Sum eosinophil basophil counts ( 27863252) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		41 interacting genes: ABL1 ATOH1 CALM1 CASP1 CCL1 CD274 CDKN2A CLIC6 CREBBP CUL4B DDIT4 ERG H2AX H2BC3 LAPTM5 MCL1 MYCN NRIP1 PCNT PIAS2 POLB POLL PPP5C PTOV1 RNF10 RNF11 SMAD2 SMAD9 SUMO2 TBP TNS2 TP53 UBA6 UBC UBE2D1 UBE2D2 UBE2G1 UBE2L3 UBE2Z WBP2 WIPI2	40 interacting genes: APEX1 BAD BAK1 BAX BBC3 BCL2L1 BCL2L11 BID BIK BMF BOK BTRC CASP3 CDC20 CHRM4 DAD1 FBXW11 GSK3A GSK3B HIF1A HRK HUWE1 KCNF1 MAPK1 MAPK10 PCNA PIN1 PMAIP1 SIRT1 SIRT2 SIRT3 STX8 TNKS TPT1 TRAF6 TRIM11 UBXN6 UHRF2 USP9X VDAC1
Entrez ID		10075	4170
HPRD ID		06608	08870
Ensembl ID		ENSG00000086758	ENSG00000143384
Uniprot IDs		Q7Z6Z7	A0A087WT64 C8YZ26 Q07820
PDB IDs		2EKK 2MUL 3G1N 3H1D 5C6H 5LP8 6FYH 6MIW 6PFL 7AZX 7JQ9 7MOP 7MWD 7MWE 7MWF 8R7O 8RD0 8RD1 8RD7	2KBW 2MHS 2NL9 2NLA 2PQK 3D7V 3IO9 3KJ0 3KJ1 3KJ2 3KZ0 3MK8 3PK1 3TWU 3WIX 3WIY 4BPI 4BPJ 4HW2 4HW3 4HW4 4OQ5 4OQ6 4WGI 4WMR 4WMS 4WMT 4WMU 4WMV 4WMW 4WMX 4ZBF 4ZBI 5C3F 5C6H 5FC4 5FDO 5FDR 5IEZ 5IF4 5JSB 5KU9 5LOF 5MES 5MEV 5UUM 5VKC 5VX2 5W89 5W8F 6B4L 6B4U 6BW2 6BW8 6FS0 6FS1 6FS2 6MBD 6MBE 6NE5 6O4U 6O6F 6O6G 6OQB 6OQC 6OQD 6OQN 6OVC 6P3P 6QB3 6QB4 6QB6 6QFC 6QFI 6QFM 6QFQ 6QGD 6QXJ 6QYK 6QYL 6QYN 6QYO 6QYP 6QZ5 6QZ6 6QZ7 6QZ8 6QZB 6STJ 6U63 6U64 6U65 6U67 6U6F 6UA3 6UAB 6UD2 6UDI 6UDT 6UDU 6UDV 6UDX 6UDY 6VBX 6YBG 6YBJ 6YBK 6YBL 6ZIE 7NB4 7NB7 7XGE 8AV9 8EKX 8EL0 8EL1 8G3S 8G3T 8G3U 8G3W 8G3X 8G3Y 8H7B 8IQM 8QSO 8SVY 8T6F 8VJP 8Y1Y 8Y1Z 8Y20 9BCG 9CKN
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification Process Nucleoplasm Protein Modification By Small Protein Conjugation Protein-containing Complex Protein Ubiquitination Ubiquitin Conjugating Enzyme Activity Ubiquitin Protein Ligase Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Nucleus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Modification-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Stress DNA Damage Response Protein Metabolic Process Negative Regulation Of Gliogenesis Intrinsic Apoptotic Signaling Pathway Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Enzyme Binding Protein Polyubiquitination Regulation Of Transcription By RNA Polymerase II Chromatin Ubiquitin-dependent Protein Catabolic Process Cytosol RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Apoptotic Signaling Pathway DNA Binding SUMO Transferase Activity Double-strand Break Repair Damaged DNA Binding Signal Transduction Catabolic Process DNA Repair SMAD Protein Signal Transduction Disordered Domain Specific Binding Regulation Of RNA Metabolic Process	Regulation Of Mitochondrion Organization Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Release Of Cytochrome C From Mitochondria Apoptotic Mitochondrial Changes Regulation Of Membrane Permeability Regulation Of Apoptotic Process Positive Regulation Of Organelle Organization Regulation Of Programmed Cell Death Regulation Of Organelle Organization Cellular Response To Stress Bcl-2 Family Protein Complex Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Mitochondrial Membrane Organization Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Membrane Permeability Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrion Organization Positive Regulation Of Membrane Permeability DNA Damage Response Mitochondrial Outer Membrane Regulation Of Autophagy Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Cellular Response To Stress Regulation Of Neuron Apoptotic Process Mitochondrion Leukocyte Apoptotic Process Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress Response To Stress Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Signal Transduction Organelle Organization Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Cellular Component Organization
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?