IL21 and FBXO25

Number of citations of the paper that reports this interaction (PubMedID 23940030)
41

Data Source:
BioGRID (enzymatic study)

		IL21	FBXO25
Description		interleukin 21	F-box protein 25
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Ubiquitin Ligase Complex Nucleus Nucleolus Cytoplasm SCF Ubiquitin Ligase Complex
	Molecular Function	Cytokine Activity Cytokine Receptor Binding Interleukin-2 Receptor Binding Protein Binding	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	Natural Killer Cell Differentiation Positive Regulation Of Cytokine Production Germinal Center B Cell Differentiation Positive Regulation Of Immunoglobulin Production Positive Regulation Of Natural Killer Cell Cytokine Production Immune Response Signal Transduction Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Cell Population Proliferation Response To Virus Positive Regulation Of B Cell Proliferation Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Tissue Remodeling Positive Regulation Of T Cell Proliferation Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Cell Development Cell Maturation Positive Regulation Of Inflammatory Response Positive Regulation Of Lymphocyte Activation Defense Response To Virus T Follicular Helper Cell Differentiation Defense Response To Other Organism Cellular Response To Virus	Protein Ubiquitination
Pathways		Interleukin-21 signaling
Drugs
Diseases		Type I diabetes mellitus
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Allergy ( 27182965) Alopecia areata ( 20596022 25608926) Alzheimer's disease in APOE e4- carriers ( 25778476) Asthma ( 31959851 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23727859 25574825 26482879) Bipolar disorder ( 31043756) Celiac disease ( 22057235 17558408 24999842 20190752 18311140) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Mosquito bite size ( 28199695) Night sleep phenotypes ( 27126917) Pediatric autoimmune diseases ( 26301688) Primary biliary cholangitis ( 28425483) Primary sclerosing cholangitis ( 23603763 27992413) Progressive supranuclear palsy ( 21685912) Rheumatoid arthritis ( 30423114 24390342) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 25751624) Ulcerative colitis ( 21297633) Vaso-occlusive pain in sickle-cell anemia ( 28584135)	Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Nontraumatic osteonecrosis of the femoral head ( 32701715)
Interacting Genes		6 interacting genes: ASPH DGKA FBXO25 IL21R S100A6 S100P	82 interacting genes: ANKRD13A APLF AXL BMX BRME1 CDK5RAP2 CDK9 CENPB CHLSN CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1
Entrez ID		59067	26260
HPRD ID		05650	16439
Ensembl ID		ENSG00000138684	ENSG00000147364
Uniprot IDs		A0A224B028 Q9HBE4	Q8TCJ0
PDB IDs		2OQP 3TGX 8ENT
Enriched GO Terms of Interacting Partners?		Calcium Ion Binding Calcium-dependent Protein Binding Interleukin-21 Receptor Activity Interleukin-21-mediated Signaling Pathway Peptidyl-aspartic Acid 3-dioxygenase Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Alkylglycerol Kinase Activity	Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Nucleus Polyubiquitin Modification-dependent Protein Binding Cytosol ATP Binding Nucleotide Binding Protein Phosphorylation Phosphorylation Protein Serine/threonine Kinase Activity Apoptotic Process Atrioventricular Node Cell Fate Commitment Nucleoplasm Cell Death Programmed Cell Death Cytoplasm Protein Serine Kinase Activity His-Purkinje System Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development Vascular Endothelial Growth Factor Binding Cellular Response To Stress Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Activity Transferase Activity Proteasomal Protein Catabolic Process Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Negative Regulation Of Endothelial Cell Apoptotic Process Ubiquitin Ligase Complex Scaffold Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Modification Process Atrial Septum Development Positive Regulation Of Natural Killer Cell Differentiation Ubiquitin-modified Protein Reader Activity ERAD Pathway Regulation Of Cell Communication Autophagosome Assembly
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