IL21 and DGKA

Number of citations of the paper that reports this interaction (PMID 8626603)
20

Data Source:
HPRD (in vivo)

		IL21	DGKA
Gene Name		interleukin 21	diacylglycerol kinase, alpha 80kDa
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space	Cytosol Plasma Membrane Membrane
	Molecular Function	Cytokine Activity Cytokine Receptor Binding Interleukin-2 Receptor Binding	NAD+ Kinase Activity Diacylglycerol Kinase Activity Calcium Ion Binding ATP Binding Phospholipid Binding
	Biological Process	Positive Regulation Of Natural Killer Cell Cytokine Production Immune Response Signal Transduction Positive Regulation Of Cell Proliferation Positive Regulation Of B Cell Proliferation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Tissue Remodeling Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Interferon-gamma Biosynthetic Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Cell Maturation Positive Regulation Of Inflammatory Response	Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Blood Coagulation Phosphorylation Platelet Activation Intracellular Signal Transduction
Pathways			G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Platelet activation, signaling and aggregation Effects of PIP2 hydrolysis
Drugs
Diseases
GWAS		Alopecia areata ( 20596022) Celiac disease ( 20190752 17558408 18311140) Inflammatory bowel disease ( 23128233) Progressive supranuclear palsy ( 21685912) Rheumatoid arthritis ( 20453842) Ulcerative colitis ( 21297633)	Vitiligo ( 22951725)
Protein-Protein Interactions		3 interactors: DGKA FBXO25 IL21R	3 interactors: IL21 SRC SREK1
Entrez ID		59067	1606
HPRD ID		05650	00517
Ensembl ID		ENSG00000138684	ENSG00000065357
Uniprot IDs		Q9HBE4	P23743
PDB IDs		2OQP 3TGX	1TUZ
Enriched GO Terms of Interacting Partners?		Interleukin-21-mediated Signaling Pathway Cell Activation	Regulation Of Tissue Remodeling Positive Regulation Of Natural Killer Cell Cytokine Production Positive Regulation Of T Cell Activation Cellular Response To Progesterone Stimulus Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Integrin Activation Negative Regulation Of Mitochondrial Depolarization Positive Regulation Of Podosome Assembly Negative Regulation Of Protein Homooligomerization Progesterone Receptor Signaling Pathway Positive Regulation Of Cytokine Production Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Podosome Assembly Regulation Of Lymphocyte Activation Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Osteoclast Development Negative Regulation Of Protein Oligomerization Regulation Of Cell Activation Positive Regulation Of Interleukin-17 Production Regulation Of Integrin Activation Positive Regulation Of Interferon-gamma Biosynthetic Process Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Regulation Of Early Endosome To Late Endosome Transport Regulation Of Cytokine Production Positive Regulation Of Natural Killer Cell Differentiation Transcytosis Signal Complex Assembly Stress Fiber Assembly Negative Regulation Of Anoikis Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Autophosphorylation Regulation Of Cell Adhesion Uterus Development Positive Regulation Of Immune Response Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Anoikis Response To Acidic PH Regulation Of Mitochondrial Depolarization Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of DNA Biosynthetic Process Negative Regulation Of Focal Adhesion Assembly Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor
Tagcloud ?		6r adeno adenocarcinoma auto batf carrying cd25 ctla4 folr4 foxp foxp3 icos il10 il6r intranasal lag3 leucine lung lungs orphan pstat3 rorc rorgammat specification squamous th17 transducer tumoural zipper
Tagcloud (Difference) ?		6r adeno adenocarcinoma auto batf carrying cd25 ctla4 folr4 foxp foxp3 icos il10 il6r intranasal lag3 leucine lung lungs orphan pstat3 rorc rorgammat specification squamous th17 transducer tumoural zipper
Tagcloud (Intersection) ?