IL21 and S100A6

Number of citations of the paper that reports this interaction (PubMedID 37759746)
234

Data Source:
BioGRID (pull down)

		IL21	S100A6
Description		interleukin 21	S100 calcium binding protein A6
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Ruffle Extracellular Region Nucleus Nuclear Envelope Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Extracellular Matrix Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Cytokine Activity Cytokine Receptor Binding Interleukin-2 Receptor Binding Protein Binding	Calcium Ion Binding Protein Binding Tropomyosin Binding Zinc Ion Binding Monoatomic Ion Transmembrane Transporter Activity Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Metal Ion Binding Calcium-dependent Protein Binding
	Biological Process	Natural Killer Cell Differentiation Positive Regulation Of Cytokine Production Germinal Center B Cell Differentiation Positive Regulation Of Immunoglobulin Production Positive Regulation Of Natural Killer Cell Cytokine Production Immune Response Signal Transduction Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Cell Population Proliferation Response To Virus Positive Regulation Of B Cell Proliferation Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Tissue Remodeling Positive Regulation Of T Cell Proliferation Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Cell Development Cell Maturation Positive Regulation Of Inflammatory Response Positive Regulation Of Lymphocyte Activation Defense Response To Virus T Follicular Helper Cell Differentiation Defense Response To Other Organism Cellular Response To Virus	Signal Transduction Axonogenesis Monoatomic Ion Transmembrane Transport Positive Regulation Of Fibroblast Proliferation
Pathways		Interleukin-21 signaling
Drugs			Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases		Type I diabetes mellitus
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Allergy ( 27182965) Alopecia areata ( 20596022 25608926) Alzheimer's disease in APOE e4- carriers ( 25778476) Asthma ( 31959851 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23727859 25574825 26482879) Bipolar disorder ( 31043756) Celiac disease ( 22057235 17558408 24999842 20190752 18311140) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Mosquito bite size ( 28199695) Night sleep phenotypes ( 27126917) Pediatric autoimmune diseases ( 26301688) Primary biliary cholangitis ( 28425483) Primary sclerosing cholangitis ( 23603763 27992413) Progressive supranuclear palsy ( 21685912) Rheumatoid arthritis ( 30423114 24390342) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 25751624) Ulcerative colitis ( 21297633) Vaso-occlusive pain in sickle-cell anemia ( 28584135)	HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)
Interacting Genes		6 interacting genes: ASPH DGKA FBXO25 IL21R S100A6 S100P	50 interacting genes: ANXA11 ANXA2 CACYBP CEP20 CEP43 CLCF1 CNTF CSF2 CSF3 CTF1 EBI3 EPO FAM25A FAM25C FAM25G FKBP4 FLT3LG GAPDH GH1 GH2 IFNB1 IFNW1 IL10 IL11 IL12A IL13 IL15 IL19 IL2 IL20 IL21 IL22 IL24 IL26 IL27 IL3 IL31 IL5 IL9 KITLG LEP MDM2 OFD1 PEX5 PPID PRL S100B SUGT1 THPO TP53
Entrez ID		59067	6277
HPRD ID		05650	00237
Ensembl ID		ENSG00000138684	ENSG00000197956
Uniprot IDs		A0A224B028 Q9HBE4	P06703
PDB IDs		2OQP 3TGX 8ENT	1K8U 1K96 1K9K 1K9P 2M1K 4YBH
Enriched GO Terms of Interacting Partners?		Calcium Ion Binding Calcium-dependent Protein Binding Interleukin-21 Receptor Activity Interleukin-21-mediated Signaling Pathway Peptidyl-aspartic Acid 3-dioxygenase Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Alkylglycerol Kinase Activity	Cytokine Activity Extracellular Space Cytokine-mediated Signaling Pathway Extracellular Region Growth Factor Activity Positive Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Proliferation Leukocyte Differentiation Cell Activation Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Immune System Process Leukocyte Activation Cytokine Receptor Binding Regulation Of Multicellular Organismal Process Lymphocyte Activation Signal Transduction Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Lymphocyte Activation Regulation Of Lymphocyte Activation Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Immune Response Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Cell Activation Lymphocyte Differentiation Mononuclear Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cell Activation Positive Regulation Of Developmental Process Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT Lymphocyte Proliferation Positive Regulation Of Cytokine Production Regulation Of Developmental Process Mononuclear Cell Proliferation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Leukocyte Proliferation Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of T Cell Activation T Cell Activation
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