IL21 and IL21R

Number of citations of the paper that reports this interaction (PMID 11418623)
76

Data Source:
HPRD (in vivo)

		IL21	IL21R
Gene Name		interleukin 21	interleukin 21 receptor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space	Integral Component Of Membrane
	Molecular Function	Cytokine Activity Cytokine Receptor Binding Interleukin-2 Receptor Binding	Interleukin-21 Receptor Activity
	Biological Process	Positive Regulation Of Natural Killer Cell Cytokine Production Immune Response Signal Transduction Positive Regulation Of Cell Proliferation Positive Regulation Of B Cell Proliferation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Tissue Remodeling Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Interferon-gamma Biosynthetic Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Cell Maturation Positive Regulation Of Inflammatory Response	Natural Killer Cell Activation Interleukin-21-mediated Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Alopecia areata ( 20596022) Celiac disease ( 20190752 17558408 18311140) Inflammatory bowel disease ( 23128233) Progressive supranuclear palsy ( 21685912) Rheumatoid arthritis ( 20453842) Ulcerative colitis ( 21297633)	Bone mineral density ( 19874204)
Protein-Protein Interactions		3 interactors: DGKA FBXO25 IL21R	2 interactors: IL21 JAK1
Entrez ID		59067	50615
HPRD ID		05650	05649
Ensembl ID		ENSG00000138684
Uniprot IDs		Q9HBE4	Q9HBE5
PDB IDs		2OQP 3TGX	3TGX
Enriched GO Terms of Interacting Partners?		Interleukin-21-mediated Signaling Pathway Cell Activation	Positive Regulation Of Natural Killer Cell Cytokine Production Regulation Of Innate Immune Response Interleukin-2-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Interferon-gamma Biosynthetic Process Positive Regulation Of Interleukin-17 Production Response To Interleukin-2 Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Natural Killer Cell Differentiation Regulation Of Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Tissue Remodeling Positive Regulation Of Interleukin-10 Production Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Immune Response Regulation Of Immune System Process Peptidyl-tyrosine Autophosphorylation Positive Regulation Of B Cell Proliferation Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Cell Proliferation Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Interferon-gamma Production Regulation Of B Cell Proliferation Response To Antibiotic Positive Regulation Of JAK-STAT Cascade Regulation Of Tissue Remodeling Positive Regulation Of Cytokine Biosynthetic Process Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of B Cell Activation Positive Regulation Of T Cell Proliferation Regulation Of Interferon-gamma Production Regulation Of JAK-STAT Cascade Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Inflammatory Response Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Mediated Cytotoxicity Immune System Process Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Cytokine Biosynthetic Process
Tagcloud ?		6r adeno adenocarcinoma auto batf carrying cd25 ctla4 folr4 foxp foxp3 icos il10 il6r intranasal lag3 leucine lung lungs orphan pstat3 rorc rorgammat specification squamous th17 transducer tumoural zipper	acquire antigen autoreactive beacon broke ccr7 cd4 cd40 cd40l cd8 cd86 consequently crosslinking dcs draining expanded histocompatibility impairing infiltration islets mhc migrate pancreas reach restored sufficient transferred transferring
Tagcloud (Difference) ?		6r adeno adenocarcinoma auto batf carrying cd25 ctla4 folr4 foxp foxp3 icos il10 il6r intranasal lag3 leucine lung lungs orphan pstat3 rorc rorgammat specification squamous th17 transducer tumoural zipper	acquire antigen autoreactive beacon broke ccr7 cd4 cd40 cd40l cd8 cd86 consequently crosslinking dcs draining expanded histocompatibility impairing infiltration islets mhc migrate pancreas reach restored sufficient transferred transferring
Tagcloud (Intersection) ?