IL21

Gene Name		interleukin 21
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space
	Molecular Function	Cytokine Activity Cytokine Receptor Binding Interleukin-2 Receptor Binding
	Biological Process	Positive Regulation Of Natural Killer Cell Cytokine Production Immune Response Signal Transduction Positive Regulation Of Cell Proliferation Positive Regulation Of B Cell Proliferation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Tissue Remodeling Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Interferon-gamma Biosynthetic Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Cell Maturation Positive Regulation Of Inflammatory Response
Pathways
Drugs
Diseases
GWAS		Alopecia areata ( 20596022) Celiac disease ( 20190752 17558408 18311140) Inflammatory bowel disease ( 23128233) Progressive supranuclear palsy ( 21685912) Rheumatoid arthritis ( 20453842) Ulcerative colitis ( 21297633)
Protein-protein Interactions		3 interactors: DGKA FBXO25 IL21R
Entrez ID		59067
HPRD ID		05650
Ensembl ID		ENSG00000138684
Uniprot IDs		Q9HBE4
PDB IDs		2OQP 3TGX
Enriched GO Terms of Interacting Partners?		Interleukin-21-mediated Signaling Pathway Cell Activation
Tagcloud ?		6r adeno adenocarcinoma auto batf carrying cd25 ctla4 folr4 foxp foxp3 icos il10 il6r intranasal lag3 leucine lung lungs orphan pstat3 rorc rorgammat specification squamous th17 transducer tumoural zipper