VAPB and VKORC1

Number of citations of the paper that reports this interaction (PubMedID 21103663)
0

Data Source:
BioGRID (two hybrid)

		VAPB	VKORC1
Description		VAMP associated protein B and C	vitamin K epoxide reductase complex subunit 1
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Endoplasmic Reticulum Exit Site Presynapse Postsynapse Glutamatergic Synapse	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Microtubule Binding Enzyme Binding FFAT Motif Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity Cadherin Binding Protein Heterodimerization Activity Beta-tubulin Binding	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Quinone Binding
	Biological Process	Intracellular Calcium Ion Homeostasis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Response To Unfolded Protein Endoplasmic Reticulum Organization Viral Release From Host Cell Cholesterol Transport Endoplasmic Reticulum Unfolded Protein Response IRE1-mediated Unfolded Protein Response Suppression Of Viral Release By Host Host-mediated Suppression Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Host-mediated Perturbation Of Viral RNA Genome Replication Positive Regulation Of Viral Genome Replication Negative Regulation By Virus Of Viral Protein Levels In Host Cell Endoplasmic Reticulum-plasma Membrane Tethering COPII-coated Vesicle Budding Endoplasmic Reticulum Membrane Organization	Xenobiotic Metabolic Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Positive Regulation Of Coagulation Bone Development
Pathways		Sphingolipid de novo biosynthesis RHOA GTPase cycle RHOC GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle	Metabolism of vitamin K
Drugs			Menadione Dicoumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD) Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease	Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS			Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Warfarin maintenance dose ( 18535201 19300499 20833655 26265036) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)
Interacting Genes		49 interacting genes: AIG1 AQP2 AQP6 BIK CD79A CFTR CYB561 CYBRD1 EBAG9 EBP ELOVL4 FAM174A GJA8 GLP1R GPR25 HSD17B13 JAGN1 KCNB1 MAILR MTNR1A OSBP OSBPL2 PTGES REEP4 RETREG3 RMDN2 RNASEK RNF111 SCN3B SLC10A1 SLC18A1 SLC22A1 SQSTM1 STARD3 STX1A STX2 STX4 STX5 TIMMDC1 TMEM101 TMX2 TTC39B USP20 VAMP1 VAMP2 VHL VKORC1 ZBTB22 ZDHHC15	93 interacting genes: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5MC3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CPLX4 CREB3 CREB3L1 CXADR DPM2 ECHDC1 FAM209A FAM210B FGG FGL1 FIS1 FTL GJB1 GORAB GPR152 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 LMNA MANBAL MSMO1 MSRB1 MT1X MUC1 PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMDN3 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC22A2 SLC25A1 SLC31A2 SLC7A14 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM35B TMEM45B TMT1B TRAM1 TREX1 VAPB YIF1A ZCCHC24
Entrez ID		9217	79001
HPRD ID		09300	10540
Ensembl ID		ENSG00000124164	ENSG00000167397
Uniprot IDs		O95292 Q53XM7	A0A0S2Z5X7 A0A0S2Z6I4 Q9BQB6
PDB IDs		2MDK 3IKK	6WV3 6WV4 6WV5 6WV6 6WV7 6WVH
Enriched GO Terms of Interacting Partners?		Membrane SNAP Receptor Activity SNARE Complex Organic Hydroxy Compound Transport Vesicle Docking SNARE Binding SNARE Complex Assembly Organelle Localization By Membrane Tethering Membrane Docking Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Vesicle Organization Endoplasmic Reticulum Membrane Membrane Fusion Regulation Of Insulin Secretion Endomembrane System Regulation Of Hormone Secretion Membrane Organization Endoplasmic Reticulum Establishment Of Localization In Cell Regulation Of Hormone Levels Regulation Of Peptide Hormone Secretion Ascorbate Homeostasis Exocytosis Positive Regulation Of Norepinephrine Secretion Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cholesterol Transport Transmembrane Monodehydroascorbate Reductase Activity Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Water Transport Transmembrane Transport Basolateral Plasma Membrane Sterol Transport Clathrin-sculpted Monoamine Transport Vesicle Membrane Positive Regulation Of Exocytosis Regulation Of Protein Secretion Protein Binding Cytoplasmic Vesicle Cornified Envelope Assembly Norepinephrine Uptake Secretion By Cell Fluid Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Chloride Channel Inhibitor Activity Neurotransmitter Transport Positive Regulation Of Secretion By Cell Regulation Of Secretion By Cell	Endoplasmic Reticulum Membrane Spherical High-density Lipoprotein Particle Very-low-density Lipoprotein Particle High-density Lipoprotein Particle High-density Lipoprotein Particle Receptor Binding Blood Microparticle Endoplasmic Reticulum Chylomicron Cholesterol Efflux Phospholipid Efflux Membrane Cholesterol Transport Phosphatidylcholine-sterol O-acyltransferase Activator Activity Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Sterol Transport Lipase Inhibitor Activity Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Plasma Lipoprotein Particle Clearance Extracellular Exosome Lipoprotein Metabolic Process Organic Hydroxy Compound Transport Asialoglycoprotein Receptor Activity Regulation Of Transport Endoplasmic Reticulum Lumen Regulation Of Intestinal Absorption Plasma Lipoprotein Particle Remodeling Response To Endoplasmic Reticulum Stress Cellular Response To Lipoprotein Particle Stimulus Protein-containing Complex Remodeling Lipid Transport Negative Regulation Of Lipid Transport Zymogen Activation Acute-phase Response Chemical Homeostasis Triglyceride Homeostasis Acylglycerol Homeostasis Peptidyl-methionine Modification Negative Regulation Of Cholesterol Import Myoblast Fusion Involved In Skeletal Muscle Regeneration Iron Ion Export Across Plasma Membrane Reverse Cholesterol Transport Regulation Of Lipid Transport Defense Response Endocytic Vesicle Lumen Cholesterol Binding Apolipoprotein Receptor Binding Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Negative Regulation Of Cholesterol Transport
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