VAPB and CYBRD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VAPB	CYBRD1
Description		VAMP associated protein B and C	cytochrome b reductase 1
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Endoplasmic Reticulum Exit Site Presynapse Postsynapse Glutamatergic Synapse	Lysosomal Membrane Plasma Membrane Membrane Apical Plasma Membrane Brush Border Membrane Extracellular Exosome
	Molecular Function	Protein Binding Microtubule Binding Enzyme Binding FFAT Motif Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity Cadherin Binding Protein Heterodimerization Activity Beta-tubulin Binding	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Metal Ions Identical Protein Binding Metal Ion Binding Transmembrane Ascorbate Ferrireductase Activity Transmembrane Monodehydroascorbate Reductase Activity
	Biological Process	Intracellular Calcium Ion Homeostasis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Response To Unfolded Protein Endoplasmic Reticulum Organization Viral Release From Host Cell Cholesterol Transport Endoplasmic Reticulum Unfolded Protein Response IRE1-mediated Unfolded Protein Response Suppression Of Viral Release By Host Host-mediated Suppression Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Host-mediated Perturbation Of Viral RNA Genome Replication Positive Regulation Of Viral Genome Replication Negative Regulation By Virus Of Viral Protein Levels In Host Cell Endoplasmic Reticulum-plasma Membrane Tethering COPII-coated Vesicle Budding Endoplasmic Reticulum Membrane Organization	Intracellular Iron Ion Homeostasis Response To Iron Ion Reductive Iron Assimilation Transmembrane Transport Multicellular Organismal-level Iron Ion Homeostasis Ascorbate Homeostasis
Pathways		Sphingolipid de novo biosynthesis RHOA GTPase cycle RHOC GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle	Iron uptake and transport
Drugs
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD) Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS			Appendicular lean mass ( 33097823) Asthma (childhood onset) ( 34022066) Body fat distribution (arm fat ratio) ( 30664634) Heel bone mineral density ( 30598549) Heel bone mineral density x serum urate levels interaction ( 34046847) Hip circumference adjusted for BMI ( 34021172) Pulse pressure ( 30224653) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		49 interacting genes: AIG1 AQP2 AQP6 BIK CD79A CFTR CYB561 CYBRD1 EBAG9 EBP ELOVL4 FAM174A GJA8 GLP1R GPR25 HSD17B13 JAGN1 KCNB1 MAILR MTNR1A OSBP OSBPL2 PTGES REEP4 RETREG3 RMDN2 RNASEK RNF111 SCN3B SLC10A1 SLC18A1 SLC22A1 SQSTM1 STARD3 STX1A STX2 STX4 STX5 TIMMDC1 TMEM101 TMX2 TTC39B USP20 VAMP1 VAMP2 VHL VKORC1 ZBTB22 ZDHHC15	20 interacting genes: CREB3 FKBP8 GIMAP5 GOSR2 HMOX1 LMNA LPAR3 NEDD4L PLP2 RABAC1 SEC22A SERP1 SERP2 STX4 STX7 TMEM120A TMEM65 VAPA VAPB ZFPL1
Entrez ID		9217	79901
HPRD ID		09300	05764
Ensembl ID		ENSG00000124164	ENSG00000071967
Uniprot IDs		O95292 Q53XM7	Q53TN4
PDB IDs		2MDK 3IKK	5ZLE 5ZLG
Enriched GO Terms of Interacting Partners?		Membrane SNAP Receptor Activity SNARE Complex Organic Hydroxy Compound Transport Vesicle Docking SNARE Binding SNARE Complex Assembly Organelle Localization By Membrane Tethering Membrane Docking Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Vesicle Organization Endoplasmic Reticulum Membrane Membrane Fusion Regulation Of Insulin Secretion Endomembrane System Regulation Of Hormone Secretion Membrane Organization Endoplasmic Reticulum Establishment Of Localization In Cell Regulation Of Hormone Levels Regulation Of Peptide Hormone Secretion Ascorbate Homeostasis Exocytosis Positive Regulation Of Norepinephrine Secretion Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cholesterol Transport Transmembrane Monodehydroascorbate Reductase Activity Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Water Transport Transmembrane Transport Basolateral Plasma Membrane Sterol Transport Clathrin-sculpted Monoamine Transport Vesicle Membrane Positive Regulation Of Exocytosis Regulation Of Protein Secretion Protein Binding Cytoplasmic Vesicle Cornified Envelope Assembly Norepinephrine Uptake Secretion By Cell Fluid Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Chloride Channel Inhibitor Activity Neurotransmitter Transport Positive Regulation Of Secretion By Cell Regulation Of Secretion By Cell	Endoplasmic Reticulum Membrane SNAP Receptor Activity Endoplasmic Reticulum Membrane Organization Membrane Fusion Endoplasmic Reticulum Unfolded Protein Response Organelle Localization By Membrane Tethering Membrane Docking Response To Unfolded Protein FFAT Motif Binding Membrane COPII-coated Vesicle Budding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum-plasma Membrane Tethering SNARE Complex Vesicle Organization Vesicle-mediated Transport Endoplasmic Reticulum Localization SNARE Binding Host-mediated Activation Of Viral Genome Replication Host-mediated Perturbation Of Viral Genome Replication Host-mediated Suppression Of Viral Genome Replication Response To Endoplasmic Reticulum Stress Organelle Localization Vesicle Fusion Organelle Membrane Fusion Endomembrane System Intracellular Transport Golgi Vesicle Transport Organelle Fusion Viral Release From Host Cell Intracellular Protein Localization Endoplasmic Reticulum Exit Site Viral Process Vesicle Budding From Membrane Protein-membrane Adaptor Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Host-mediated Activation Of Viral Process Positive Regulation Of Developmental Growth Regulation Of Protein Localization To Cell Surface Regulation Of Apoptotic Signaling Pathway Perinuclear Region Of Cytoplasm Cellular Localization Protein Transport Sphingomyelin Phosphodiesterase Activator Activity Positive Regulation Of Deacetylase Activity Establishment Of Localization In Cell Cellular Response To Stress Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Heme Oxidation
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