VAPB and USP20

Number of citations of the paper that reports this interaction (PMID 19615732)
279

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		VAPB	USP20
Gene Name		VAMP (vesicle-associated membrane protein)-associated protein B and C	ubiquitin specific peptidase 20
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Integral Component Of Membrane Endoplasmic Reticulum Exit Site	Centrosome Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Microtubule Binding Enzyme Binding FFAT Motif Binding Protein Homodimerization Activity Protein Heterodimerization Activity Beta-tubulin Binding	G-protein Coupled Receptor Binding Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding
	Biological Process	Sphingolipid Metabolic Process Cellular Calcium Ion Homeostasis ER To Golgi Vesicle-mediated Transport Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Endoplasmic Reticulum Organization Modulation By Virus Of Host Morphology Or Physiology Sphingolipid Biosynthetic Process Endoplasmic Reticulum Unfolded Protein Response Small Molecule Metabolic Process Negative Regulation By Host Of Viral Release From Host Cell Positive Regulation By Host Of Viral Release From Host Cell Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Genome Replication Positive Regulation Of Viral Genome Replication Negative Regulation By Virus Of Viral Protein Levels In Host Cell COPII-coated Vesicle Budding	Endocytosis Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways		Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: FAF1 GPR25 MTNR1A OSBPL2 RMDN2 STX1A STX2 STX4 STX5 USP20 VAMP1 VAMP2 VAPA VHL VKORC1	20 interactors: ALAS1 BEND5 BEND7 CCDC36 DIO2 FATE1 HIF1A MAGEA11 MDFI PJA1 PLA2G2A PRKCI RAD17 SPRY2 TRIM23 USP15 USP21 USP28 VAPB VHL
Entrez ID		9217	10868
HPRD ID		09300	07505
Ensembl ID		ENSG00000124164	ENSG00000136878
Uniprot IDs		O95292 Q53XM7	Q9Y2K6
PDB IDs		3IKK
Enriched GO Terms of Interacting Partners?		Vesicle Fusion Membrane Fusion Organelle Fusion Vesicle Organization Synaptic Vesicle Fusion To Presynaptic Membrane Synaptic Vesicle Exocytosis Vesicle Docking Membrane Docking Membrane Organization Vesicle-mediated Transport Neurotransmitter Secretion Synaptic Vesicle Transport Exocytosis Regulation Of Neurotransmitter Levels Calcium Ion-dependent Exocytosis Neurotransmitter Transport Cellular Protein Localization Establishment Of Vesicle Localization Vesicle Localization Secretion By Cell Golgi Vesicle Transport SNARE Complex Assembly Cellular Localization Secretion Establishment Of Organelle Localization Positive Regulation Of Synaptic Transmission Protein Localization Establishment Of Localization In Cell Organelle Localization Response To Hydroperoxide Glutamate Secretion Regulation Of Exocytosis Intracellular Protein Transport Intracellular Transport Regulation Of Insulin Secretion Pathogenesis Regulation Of Peptide Hormone Secretion Synaptic Transmission Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Protein Transport Long-term Synaptic Potentiation Regulation Of Hormone Secretion Regulation Of Establishment Of Protein Localization Transport Acid Secretion Positive Regulation Of Exocytosis Regulation Of Synaptic Transmission Protein Transport Regulation Of Protein Localization Organelle Organization	Protein Deubiquitination Protein Modification By Small Protein Removal Cellular Metabolic Process Histone Deubiquitination Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Stress Regulation Of Proteasomal Protein Catabolic Process Localization Within Membrane Protein Catabolic Process Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Proteasomal Protein Catabolic Process Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation By Host Of Viral Release From Host Cell Neural Fold Elevation Formation Embryonic Organ Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Membrane Budding Histone H2B Conserved C-terminal Lysine Deubiquitination Elastin Metabolic Process Negative Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Release From Host Cell Thyroid Hormone Catabolic Process Response To Interleukin-1 Regulation Of Cell Proliferation Positive Regulation Of Cell Differentiation Regulation Of Protein Catabolic Process Cellular Response To Hypoxia Cellular Response To Stimulus Cellular Response To Decreased Oxygen Levels Positive Regulation Of Catalytic Activity Cellular Protein Modification Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Chemokine-mediated Signaling Pathway Vascular Endothelial Growth Factor Production Negative Regulation Of Apoptotic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Programmed Cell Death Cellular Protein Metabolic Process Establishment Of Cell Polarity Cellular Response To Oxygen Levels Response To Stimulus Protein Metabolic Process Embryonic Placenta Development
Tagcloud ?		2alpha bip centrally chaperone chlamydia chlamydiae chlamydial cpn eif2alpha endoplasmic er eukaryotic exogenous gamma grp78 ifn inclusions inducer interacted interplay maintain persistent pneumoniae productive restore reticulum unfolded upr vesicle	ablated adrenergic arrestin ars betaar blocker carvedilol desensitization deubiquitinases e3 endogenously flag hek interacted internalized itinerary ligase lysosomal machineries march2 proteomics recruit recycling serves stabilized ubiquitinated ubiquitination usp33 vsmcs
Tagcloud (Difference) ?		2alpha bip centrally chaperone chlamydia chlamydiae chlamydial cpn eif2alpha endoplasmic er eukaryotic exogenous gamma grp78 ifn inclusions inducer interplay maintain persistent pneumoniae productive restore reticulum unfolded upr vesicle	ablated adrenergic arrestin ars betaar blocker carvedilol desensitization deubiquitinases e3 endogenously flag hek internalized itinerary ligase lysosomal machineries march2 proteomics recruit recycling serves stabilized ubiquitinated ubiquitination usp33 vsmcs
Tagcloud (Intersection) ?		interacted