VAPB and STX2

Number of citations of the paper that reports this interaction (PMID 12651853)
5

Data Source:
BioGRID (pull down)

		VAPB	STX2
Gene Name		VAMP (vesicle-associated membrane protein)-associated protein B and C	syntaxin 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Integral Component Of Membrane Endoplasmic Reticulum Exit Site	Extracellular Space Plasma Membrane Cell-cell Junction Synaptic Vesicle Cell Surface Endomembrane System Integral Component Of Membrane Basolateral Plasma Membrane Lamellipodium SNARE Complex Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Microtubule Binding Enzyme Binding FFAT Motif Binding Protein Homodimerization Activity Protein Heterodimerization Activity Beta-tubulin Binding	SNARE Binding SNAP Receptor Activity Protein Binding Protein Dimerization Activity Calcium-dependent Protein Binding
	Biological Process	Sphingolipid Metabolic Process Cellular Calcium Ion Homeostasis ER To Golgi Vesicle-mediated Transport Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Endoplasmic Reticulum Organization Modulation By Virus Of Host Morphology Or Physiology Sphingolipid Biosynthetic Process Endoplasmic Reticulum Unfolded Protein Response Small Molecule Metabolic Process Negative Regulation By Host Of Viral Release From Host Cell Positive Regulation By Host Of Viral Release From Host Cell Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Genome Replication Positive Regulation Of Viral Genome Replication Negative Regulation By Virus Of Viral Protein Levels In Host Cell COPII-coated Vesicle Budding	Intracellular Protein Transport Signal Transduction Acrosome Reaction Ectoderm Development Organ Morphogenesis Cell Differentiation Regulation Of Blood Coagulation Synaptic Vesicle Fusion To Presynaptic Membrane Response To Hydroperoxide Vesicle Docking Protein Oligomerization Regulation Of Cytoskeleton Organization
Pathways		Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: FAF1 GPR25 MTNR1A OSBPL2 RMDN2 STX1A STX2 STX4 STX5 USP20 VAMP1 VAMP2 VAPA VHL VKORC1	12 interactors: CPLX2 SNAP23 SNAP25 STXBP1 STXBP2 SYT1 SYT4 SYT7 UNC13B VAMP2 VAMP3 VAPB
Entrez ID		9217	2054
HPRD ID		09300	11816
Ensembl ID		ENSG00000124164	ENSG00000111450
Uniprot IDs		O95292 Q53XM7	P32856
PDB IDs		3IKK
Enriched GO Terms of Interacting Partners?		Vesicle Fusion Membrane Fusion Organelle Fusion Vesicle Organization Synaptic Vesicle Fusion To Presynaptic Membrane Synaptic Vesicle Exocytosis Vesicle Docking Membrane Docking Membrane Organization Vesicle-mediated Transport Neurotransmitter Secretion Synaptic Vesicle Transport Exocytosis Regulation Of Neurotransmitter Levels Calcium Ion-dependent Exocytosis Neurotransmitter Transport Cellular Protein Localization Establishment Of Vesicle Localization Vesicle Localization Secretion By Cell Golgi Vesicle Transport SNARE Complex Assembly Cellular Localization Secretion Establishment Of Organelle Localization Positive Regulation Of Synaptic Transmission Protein Localization Establishment Of Localization In Cell Organelle Localization Response To Hydroperoxide Glutamate Secretion Regulation Of Exocytosis Intracellular Protein Transport Intracellular Transport Regulation Of Insulin Secretion Pathogenesis Regulation Of Peptide Hormone Secretion Synaptic Transmission Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Protein Transport Long-term Synaptic Potentiation Regulation Of Hormone Secretion Regulation Of Establishment Of Protein Localization Transport Acid Secretion Positive Regulation Of Exocytosis Regulation Of Synaptic Transmission Protein Transport Regulation Of Protein Localization Organelle Organization	Exocytosis Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Secretion By Cell Neurotransmitter Transport Secretion Regulation Of Exocytosis Vesicle Docking Vesicle-mediated Transport Membrane Docking Regulation Of Secretion Synaptic Vesicle Transport Synaptic Vesicle Exocytosis Vesicle Docking Involved In Exocytosis Establishment Of Localization In Cell Glutamate Secretion Cellular Localization Regulation Of Cellular Localization Regulation Of Vesicle-mediated Transport Establishment Of Vesicle Localization Vesicle Localization Cell-cell Signaling Establishment Of Organelle Localization Acid Secretion Organelle Localization Dicarboxylic Acid Transport Vesicle Organization Regulation Of Synaptic Transmission Synaptic Transmission Leukocyte Degranulation Transport Synaptic Vesicle Priming Vesicle Fusion Amino Acid Transport Regulation Of Calcium Ion-dependent Exocytosis Regulated Secretory Pathway Regulation Of Synaptic Plasticity Positive Regulation Of Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Organelle Fusion Membrane Organization Positive Regulation Of Synaptic Transmission Carboxylic Acid Transport Organic Acid Transport Anion Transport Membrane Fusion Regulation Of Vesicle Fusion Leukocyte Activation Involved In Immune Response Endomembrane System Organization Organic Anion Transport
Tagcloud ?		2alpha bip centrally chaperone chlamydia chlamydiae chlamydial cpn eif2alpha endoplasmic er eukaryotic exogenous gamma grp78 ifn inclusions inducer interacted interplay maintain persistent pneumoniae productive restore reticulum unfolded upr vesicle	alter apc apoptotic bcl2 challenged chop contributing cytoprotective decreasing dr5 enterohemorrhagic fold hemolytic hsp40 kidneys later producing ribotoxic rodentium saline shiga spliced toxigenic toxins transcripts untreated uremic xbp1
Tagcloud (Difference) ?		2alpha bip centrally chaperone chlamydia chlamydiae chlamydial cpn eif2alpha endoplasmic er eukaryotic exogenous gamma grp78 ifn inclusions inducer interacted interplay maintain persistent pneumoniae productive restore reticulum unfolded upr vesicle	alter apc apoptotic bcl2 challenged chop contributing cytoprotective decreasing dr5 enterohemorrhagic fold hemolytic hsp40 kidneys later producing ribotoxic rodentium saline shiga spliced toxigenic toxins transcripts untreated uremic xbp1
Tagcloud (Intersection) ?