VAPB and GPR25

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		VAPB	GPR25
Gene Name		VAMP (vesicle-associated membrane protein)-associated protein B and C	G protein-coupled receptor 25
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Integral Component Of Membrane Endoplasmic Reticulum Exit Site	Integral Component Of Plasma Membrane
	Molecular Function	Protein Binding Microtubule Binding Enzyme Binding FFAT Motif Binding Protein Homodimerization Activity Protein Heterodimerization Activity Beta-tubulin Binding	G-protein Coupled Receptor Activity
	Biological Process	Sphingolipid Metabolic Process Cellular Calcium Ion Homeostasis ER To Golgi Vesicle-mediated Transport Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Endoplasmic Reticulum Organization Modulation By Virus Of Host Morphology Or Physiology Sphingolipid Biosynthetic Process Endoplasmic Reticulum Unfolded Protein Response Small Molecule Metabolic Process Negative Regulation By Host Of Viral Release From Host Cell Positive Regulation By Host Of Viral Release From Host Cell Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Genome Replication Positive Regulation Of Viral Genome Replication Negative Regulation By Virus Of Viral Protein Levels In Host Cell COPII-coated Vesicle Budding	G-protein Coupled Receptor Signaling Pathway
Pathways		Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: FAF1 GPR25 MTNR1A OSBPL2 RMDN2 STX1A STX2 STX4 STX5 USP20 VAMP1 VAMP2 VAPA VHL VKORC1	8 interactors: CCDC155 CREB3L1 FATE1 GGT7 MAP3K7 NAALADL2 PNMA1 VAPB
Entrez ID		9217	2848
HPRD ID		09300	03707
Ensembl ID		ENSG00000124164	ENSG00000170128
Uniprot IDs		O95292 Q53XM7	O00155
PDB IDs		3IKK
Enriched GO Terms of Interacting Partners?		Vesicle Fusion Membrane Fusion Organelle Fusion Vesicle Organization Synaptic Vesicle Fusion To Presynaptic Membrane Synaptic Vesicle Exocytosis Vesicle Docking Membrane Docking Membrane Organization Vesicle-mediated Transport Neurotransmitter Secretion Synaptic Vesicle Transport Exocytosis Regulation Of Neurotransmitter Levels Calcium Ion-dependent Exocytosis Neurotransmitter Transport Cellular Protein Localization Establishment Of Vesicle Localization Vesicle Localization Secretion By Cell Golgi Vesicle Transport SNARE Complex Assembly Cellular Localization Secretion Establishment Of Organelle Localization Positive Regulation Of Synaptic Transmission Protein Localization Establishment Of Localization In Cell Organelle Localization Response To Hydroperoxide Glutamate Secretion Regulation Of Exocytosis Intracellular Protein Transport Intracellular Transport Regulation Of Insulin Secretion Pathogenesis Regulation Of Peptide Hormone Secretion Synaptic Transmission Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Protein Transport Long-term Synaptic Potentiation Regulation Of Hormone Secretion Regulation Of Establishment Of Protein Localization Transport Acid Secretion Positive Regulation Of Exocytosis Regulation Of Synaptic Transmission Protein Transport Regulation Of Protein Localization Organelle Organization	Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Stress Cellular Response To Unfolded Protein Chromosome Localization To Nuclear Envelope Involved In Synapsis Negative Regulation By Host Of Viral Release From Host Cell ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Response To Stress Response To Unfolded Protein Negative Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Release From Host Cell Response To Endoplasmic Reticulum Stress Positive Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Process Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Viral Release From Host Cell Nitrogen Compound Metabolic Process I-kappaB Phosphorylation Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Necroptotic Process
Tagcloud ?		2alpha bip centrally chaperone chlamydia chlamydiae chlamydial cpn eif2alpha endoplasmic er eukaryotic exogenous gamma grp78 ifn inclusions inducer interacted interplay maintain persistent pneumoniae productive restore reticulum unfolded upr vesicle	3p atherogenesis causality cdkn1b csf3 dedifferentiation experimentation genemania gpcr gpr1 gpr124 gpr171 gpr176 gpr32 gpr64 gprc5a hbp1 id2 il12 ingenuity intima moxldl nexus quiescent smc smcs themes transcriptomic zeb1
Tagcloud (Difference) ?		2alpha bip centrally chaperone chlamydia chlamydiae chlamydial cpn eif2alpha endoplasmic er eukaryotic exogenous gamma grp78 ifn inclusions inducer interacted interplay maintain persistent pneumoniae productive restore reticulum unfolded upr vesicle	3p atherogenesis causality cdkn1b csf3 dedifferentiation experimentation genemania gpcr gpr1 gpr124 gpr171 gpr176 gpr32 gpr64 gprc5a hbp1 id2 il12 ingenuity intima moxldl nexus quiescent smc smcs themes transcriptomic zeb1
Tagcloud (Intersection) ?