VAPB and SLC18A1

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		VAPB	SLC18A1
Description		VAMP associated protein B and C	solute carrier family 18 member A1
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Endoplasmic Reticulum Exit Site Presynapse Postsynapse Glutamatergic Synapse	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Transport Vesicle Membrane Secretory Granule Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Terminal Bouton Synapse Clathrin-sculpted Monoamine Transport Vesicle Membrane Presynapse
	Molecular Function	Protein Binding Microtubule Binding Enzyme Binding FFAT Motif Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity Cadherin Binding Protein Heterodimerization Activity Beta-tubulin Binding	Serotonin:sodium:chloride Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Monoamine:proton Antiporter Activity Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity
	Biological Process	Intracellular Calcium Ion Homeostasis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Response To Unfolded Protein Endoplasmic Reticulum Organization Viral Release From Host Cell Cholesterol Transport Endoplasmic Reticulum Unfolded Protein Response IRE1-mediated Unfolded Protein Response Suppression Of Viral Release By Host Host-mediated Suppression Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Host-mediated Perturbation Of Viral RNA Genome Replication Positive Regulation Of Viral Genome Replication Negative Regulation By Virus Of Viral Protein Levels In Host Cell Endoplasmic Reticulum-plasma Membrane Tethering COPII-coated Vesicle Budding Endoplasmic Reticulum Membrane Organization	Neurotransmitter Transport Serotonin Transport Aminergic Neurotransmitter Loading Into Synaptic Vesicle Monoamine Transport Dopamine Transport Xenobiotic Transport Serotonin Uptake Norepinephrine Uptake Establishment Of Localization In Cell Transmembrane Transport Dopamine Uptake Proton Transmembrane Transport
Pathways		Sphingolipid de novo biosynthesis RHOA GTPase cycle RHOC GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle
Drugs			Reserpine Norepinephrine Ephedra sinica root MMDA Metamfetamine
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD) Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS			Apolipoprotein A1 levels ( 32203549) Cholesterol ( 31902109) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels ( 32203549) Hypertriglyceridemia ( 23505323) Major depressive disorder (broad) ( 20038947) Metabolic syndrome ( 30382898 31589552) Persistent hepatitis B virus infection ( 27244555) Pulse pressure ( 27841878) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549) Triglyceride levels in HIV infection ( 33109212) Triglycerides ( 18193046 24886709)
Interacting Genes		49 interacting genes: AIG1 AQP2 AQP6 BIK CD79A CFTR CYB561 CYBRD1 EBAG9 EBP ELOVL4 FAM174A GJA8 GLP1R GPR25 HSD17B13 JAGN1 KCNB1 MAILR MTNR1A OSBP OSBPL2 PTGES REEP4 RETREG3 RMDN2 RNASEK RNF111 SCN3B SLC10A1 SLC18A1 SLC22A1 SQSTM1 STARD3 STX1A STX2 STX4 STX5 TIMMDC1 TMEM101 TMX2 TTC39B USP20 VAMP1 VAMP2 VHL VKORC1 ZBTB22 ZDHHC15	88 interacting genes: ADGRE2 AGTRAP ANKRD46 APOL2 BRICD5 BTN2A2 C1GALT1 C2CD2L CCL4 CCL4L2 CD81 CNIH1 COL4A5 CTSA CXCL16 CYB561D2 ERMP1 FAM3C FCER1G FXYD3 GIMAP1 GJB2 GPR151 HTATIP2 INSIG2 LAT MALL MARCHF2 MFSD6 MGAM MGLL MIP MS4A1 MS4A13 NEU1 NRM OLFM4 ORMDL1 PEX16 PLP1 PLP2 PMP22 PNLIPRP1 RABAC1 RPRM SCD SEC22A SELENOK SERP1 SLC30A2 SLC30A3 SLC30A8 SLC35B4 SLC35G1 SLC38A7 SLC39A2 SMCO4 SMIM1 STX2 STX7 STX8 SYNGR1 TECR TFRC TMEM120B TMEM128 TMEM147 TMEM14A TMEM14B TMEM14C TMEM203 TMEM218 TMEM239 TMEM42 TMEM60 TMEM65 TMEM86A TMEM97 TSPO2 UPK1B UPK2 VAMP5 VAPA VAPB VTI1B YIPF1 YIPF4 YIPF6
Entrez ID		9217	6570
HPRD ID		09300	01897
Ensembl ID		ENSG00000124164	ENSG00000036565
Uniprot IDs		O95292 Q53XM7	P54219 Q96GL6
PDB IDs		2MDK 3IKK	8TGG 8TGH 8TGI 8TGJ 8TGK 8TGL 8TGM 8TGN
Enriched GO Terms of Interacting Partners?		Membrane SNAP Receptor Activity SNARE Complex Organic Hydroxy Compound Transport Vesicle Docking SNARE Binding SNARE Complex Assembly Organelle Localization By Membrane Tethering Membrane Docking Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Vesicle Organization Endoplasmic Reticulum Membrane Membrane Fusion Regulation Of Insulin Secretion Endomembrane System Regulation Of Hormone Secretion Membrane Organization Endoplasmic Reticulum Establishment Of Localization In Cell Regulation Of Hormone Levels Regulation Of Peptide Hormone Secretion Ascorbate Homeostasis Exocytosis Positive Regulation Of Norepinephrine Secretion Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cholesterol Transport Transmembrane Monodehydroascorbate Reductase Activity Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Water Transport Transmembrane Transport Basolateral Plasma Membrane Sterol Transport Clathrin-sculpted Monoamine Transport Vesicle Membrane Positive Regulation Of Exocytosis Regulation Of Protein Secretion Protein Binding Cytoplasmic Vesicle Cornified Envelope Assembly Norepinephrine Uptake Secretion By Cell Fluid Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Chloride Channel Inhibitor Activity Neurotransmitter Transport Positive Regulation Of Secretion By Cell Regulation Of Secretion By Cell	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Plasma Membrane Membrane Docking Protein Binding SNAP Receptor Activity Organelle Localization By Membrane Tethering Chloride Channel Inhibitor Activity Membrane Organization Zinc Ion Transmembrane Transporter Activity Vesicle-mediated Transport Zinc Ion Transmembrane Transport Zinc Ion Transport Membrane Fusion Zinc Ion Import Into Organelle Cellular Localization Endomembrane System FFAT Motif Binding Monoatomic Cation Transmembrane Transporter Activity SNARE Complex Zinc Ion Import Into Lysosome Vesicle Fusion Organelle Membrane Fusion Lysosome Zinc:proton Antiporter Activity COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Vesicle Docking Establishment Of Localization In Cell Vesicle SNARE Binding Intracellular Transport Fatty Acid Biosynthetic Process Gap Junction-mediated Intercellular Transport Cytoplasmic Vesicle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Positive Regulation Of Protein Catabolic Process In The Vacuole Endoplasmic Reticulum Localization Vesicle Fusion With Golgi Apparatus Organelle Fusion Golgi Vesicle Transport Transmembrane Transport Lysosomal Membrane Vacuolar Transmembrane Transport Synaptic Vesicle Golgi Trans Cisterna Secretory Vesicle Golgi Medial Cisterna Metal Ion Transport
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