VAPB and OSBPL2

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)

		VAPB	OSBPL2
Description		VAMP associated protein B and C	oxysterol binding protein like 2
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Endoplasmic Reticulum Exit Site Presynapse Postsynapse Glutamatergic Synapse	Cytoplasm Lipid Droplet Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Perinuclear Endoplasmic Reticulum Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse
	Molecular Function	Protein Binding Microtubule Binding Enzyme Binding FFAT Motif Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity Cadherin Binding Protein Heterodimerization Activity Beta-tubulin Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Phosphatidylinositol Transfer Activity Cholesterol Binding Sterol Transfer Activity Cholesterol Transfer Activity
	Biological Process	Intracellular Calcium Ion Homeostasis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Response To Unfolded Protein Endoplasmic Reticulum Organization Viral Release From Host Cell Cholesterol Transport Endoplasmic Reticulum Unfolded Protein Response IRE1-mediated Unfolded Protein Response Suppression Of Viral Release By Host Host-mediated Suppression Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Host-mediated Perturbation Of Viral RNA Genome Replication Positive Regulation Of Viral Genome Replication Negative Regulation By Virus Of Viral Protein Levels In Host Cell Endoplasmic Reticulum-plasma Membrane Tethering COPII-coated Vesicle Budding Endoplasmic Reticulum Membrane Organization	Bile Acid Biosynthetic Process Lipid Transport Plasma Membrane Organization Regulation Of Synaptic Vesicle Priming Phospholipid Transport Cholesterol Transport Intracellular Cholesterol Transport Protein Homotetramerization Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Intermembrane Lipid Transfer
Pathways		Sphingolipid de novo biosynthesis RHOA GTPase cycle RHOC GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle	Synthesis of bile acids and bile salts
Drugs
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD) Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS			Bipolar disorder ( 34002096) Estimated glomerular filtration rate ( 31152163) Femoral neck bone mineral density ( 29499414) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lumbar spine bone mineral density ( 29499414) Nicotine dependence symptom count ( 25555482) Prostate cancer ( 23535732) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		49 interacting genes: AIG1 AQP2 AQP6 BIK CD79A CFTR CYB561 CYBRD1 EBAG9 EBP ELOVL4 FAM174A GJA8 GLP1R GPR25 HSD17B13 JAGN1 KCNB1 MAILR MTNR1A OSBP OSBPL2 PTGES REEP4 RETREG3 RMDN2 RNASEK RNF111 SCN3B SLC10A1 SLC18A1 SLC22A1 SQSTM1 STARD3 STX1A STX2 STX4 STX5 TIMMDC1 TMEM101 TMX2 TTC39B USP20 VAMP1 VAMP2 VHL VKORC1 ZBTB22 ZDHHC15	4 interacting genes: SNAP25 SNRPF UBC VAPB
Entrez ID		9217	9885
HPRD ID		09300	09473
Ensembl ID		ENSG00000124164	ENSG00000130703
Uniprot IDs		O95292 Q53XM7	A0A2R8YDU7 B4DKJ8 E7ET92 Q9H1P3
PDB IDs		2MDK 3IKK	5ZM8
Enriched GO Terms of Interacting Partners?		Membrane SNAP Receptor Activity SNARE Complex Organic Hydroxy Compound Transport Vesicle Docking SNARE Binding SNARE Complex Assembly Organelle Localization By Membrane Tethering Membrane Docking Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Vesicle Organization Endoplasmic Reticulum Membrane Membrane Fusion Regulation Of Insulin Secretion Endomembrane System Regulation Of Hormone Secretion Membrane Organization Endoplasmic Reticulum Establishment Of Localization In Cell Regulation Of Hormone Levels Regulation Of Peptide Hormone Secretion Ascorbate Homeostasis Exocytosis Positive Regulation Of Norepinephrine Secretion Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cholesterol Transport Transmembrane Monodehydroascorbate Reductase Activity Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Water Transport Transmembrane Transport Basolateral Plasma Membrane Sterol Transport Clathrin-sculpted Monoamine Transport Vesicle Membrane Positive Regulation Of Exocytosis Regulation Of Protein Secretion Protein Binding Cytoplasmic Vesicle Cornified Envelope Assembly Norepinephrine Uptake Secretion By Cell Fluid Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Chloride Channel Inhibitor Activity Neurotransmitter Transport Positive Regulation Of Secretion By Cell Regulation Of Secretion By Cell	Membrane Docking Organelle Localization By Membrane Tethering Vesicle Organization Ribbon Synapse Vesicle Dense Core Granule Exocytosis Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Calcium Ion-regulated Exocytosis Of Neurotransmitter Vesicle Fusion To Plasma Membrane Presynaptic Dense Core Vesicle Exocytosis Neuronal Dense Core Vesicle Exocytosis U4 SnRNP U7 SnRNP PICln-Sm Protein Complex 7-methylguanosine Cap Hypermethylation Endoplasmic Reticulum Localization FFAT Motif Binding Host-mediated Activation Of Viral Genome Replication COPII-coated Vesicle Budding Negative Regulation By Virus Of Viral Protein Levels In Host Cell IRE1-mediated Unfolded Protein Response Endoplasmic Reticulum-plasma Membrane Tethering Host-mediated Perturbation Of Viral Genome Replication Host-mediated Perturbation Of Viral RNA Genome Replication Synaptic Vesicle Docking Somatodendritic Compartment Synaptic Vesicle Membrane Organization BLOC-1 Complex Synaptic Vesicle Priming SMN-Sm Protein Complex Small Nuclear Ribonucleoprotein Complex Methylosome Protein Tag Activity Suppression Of Viral Release By Host Endoplasmic Reticulum Membrane Organization Host-mediated Suppression Of Viral Genome Replication Organelle Localization Syntaxin-1 Binding U1 SnRNP Secretory Granule Localization U5 SnRNP U2-type Prespliceosome Assembly U12-type Spliceosomal Complex Glutamatergic Synapse Neurotransmitter Uptake U2-type Spliceosomal Complex U2-type Catalytic Step 2 Spliceosome U2 SnRNP Viral Release From Host Cell
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