GNAI3 and S1PR1

Number of citations of the paper that reports this interaction (PMID 8626678)
27

Data Source:
BioGRID (affinity chromatography technology, pull down, two hybrid)
HPRD (in vivo, two hybrid, in vitro)

		GNAI3	S1PR1
Gene Name		guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	sphingosine-1-phosphate receptor 1
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Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Golgi Apparatus Centrosome Heterotrimeric G-protein Complex Plasma Membrane Membrane Midbody Zymogen Granule Membrane Raft Extracellular Vesicular Exosome	Endosome Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Intrinsic Component Of Plasma Membrane Membrane Raft
	Molecular Function	GTPase Activity Signal Transducer Activity GTP Binding Protein Domain Specific Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding GTPase Activating Protein Binding Metal Ion Binding	G-protein Coupled Receptor Binding G-protein Coupled Receptor Activity Sphingosine-1-phosphate Receptor Activity Sphingolipid Binding
	Biological Process	Transport Vesicle Fusion Cell Cycle Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Synaptic Transmission Blood Coagulation Platelet Activation Cell Division	Angiogenesis Blood Vessel Maturation Cardiac Muscle Tissue Growth Involved In Heart Morphogenesis Sphingosine-1-phosphate Signaling Pathway Chemotaxis Cell Adhesion G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Brain Development Cell Migration Transmission Of Nerve Impulse Lamellipodium Assembly Regulation Of Cell Adhesion Neuron Differentiation Positive Regulation Of Cell Migration Regulation Of Bone Mineralization Actin Cytoskeleton Reorganization Positive Regulation Of Ras GTPase Activity Regulation Of Bone Resorption Endothelial Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Positive Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Negative Regulation Of Stress Fiber Assembly Heart Trabecula Morphogenesis T Cell Migration
Pathways		GABA B receptor activation GABA receptor activation Adenylate cyclase inhibitory pathway Signaling by GPCR PLC beta mediated events Activation of GABAB receptors G alpha (s) signalling events Opioid Signalling Signal amplification G-protein mediated events Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway GPCR downstream signaling G-protein activation G alpha (z) signalling events G alpha (i) signalling events Platelet activation, signaling and aggregation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Transmission across Chemical Synapses	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Lysosphingolipid and LPA receptors
Drugs
Diseases
GWAS		Major depressive disorder ( 20125088)
Protein-Protein Interactions		40 interactors: AGTR2 ATP12A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 ESR1 GNB2 GNB4 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SOX30 TSHR	8 interactors: AKT1 CAV1 CMSS1 GNAI1 GNAI3 HTR1A HTR1D PDGFRB
Entrez ID		2773	1901
HPRD ID		00765	03578
Ensembl ID			ENSG00000170989
Uniprot IDs		P08754 Q5TZX1	P21453
PDB IDs		2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S	3V2W 3V2Y
Enriched GO Terms of Interacting Partners?		Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Hydrolase Activity Positive Regulation Of Catalytic Activity G-protein Coupled Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Regulation Of Signaling G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Signal Transduction Regulation Of Signal Transduction Signaling Cell Communication Positive Regulation Of Metabolic Process Response To Stimulus Cellular Response To Stimulus Regulation Of Cellular Process Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Chemical Homeostasis Regulation Of Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Behavior Cytosolic Calcium Ion Homeostasis Regulation Of Behavior Single-organism Behavior Metal Ion Homeostasis Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Homeostatic Process Cellular Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Negative Regulation Of Dopamine Secretion Blood Circulation Regulation Of Phospholipase Activity Cellular Chemical Homeostasis Regulation Of Nitric-oxide Synthase Activity Cellular Response To Glucagon Stimulus Positive Regulation Of Cell Proliferation Regulation Of Hormone Secretion	Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Vasoconstriction G-protein Coupled Receptor Signaling Pathway Wound Healing Response To Wounding Cell Surface Receptor Signaling Pathway Regulation Of Blood Vessel Size Regulation Of Tube Size Blood Coagulation Hemostasis Serotonin Receptor Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Body Fluid Levels Regulation Of Ion Transport Regulation Of Behavior Platelet Activation Positive Regulation Of Ion Transport Vesicle Organization Signal Transduction Nitric Oxide Metabolic Process Positive Regulation Of Vasoconstriction Response To Hyperoxia Reactive Nitrogen Species Metabolic Process Response To Fluid Shear Stress Signaling Regulation Of Nitric-oxide Synthase Activity Cell Communication Membrane Organization Response To Stress Regulation Of Lipid Metabolic Process Blood Circulation Response To Hormone Negative Regulation Of Ion Transmembrane Transport Vesicle Fusion Negative Regulation Of Transmembrane Transport Regulation Of Vasoconstriction Regulation Of Nitric Oxide Biosynthetic Process Cellular Response To Stimulus Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Ion Transmembrane Transport T Cell Costimulation Regulation Of Oxidoreductase Activity Organelle Fusion Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Fatty Acid Metabolic Process Regulation Of Endothelial Cell Proliferation Positive Regulation Of Reactive Oxygen Species Metabolic Process
Tagcloud ?		akin angles asymmetric combine cooperatively delamination divisions e15 embryogenesis epidermis expands galphai3 genetics hitherto lend lentiviral lgn minsc morphogenesis orientation par3 perpendicular planar polarize revealing spindle uncover unspecified untested	148a accordingly adjacent carcinoma downregulated downregulation hepatocellular hepg2 inhibitory interfering invasion malignancies markedly microrna mimics mir negatively never notably numerous phosphate restoration reversed sipr1 sphingosine suppressor transfection upregulation whose
Tagcloud (Difference) ?		akin angles asymmetric combine cooperatively delamination divisions e15 embryogenesis epidermis expands galphai3 genetics hitherto lend lentiviral lgn minsc morphogenesis orientation par3 perpendicular planar polarize revealing spindle uncover unspecified untested	148a accordingly adjacent carcinoma downregulated downregulation hepatocellular hepg2 inhibitory interfering invasion malignancies markedly microrna mimics mir negatively never notably numerous phosphate restoration reversed sipr1 sphingosine suppressor transfection upregulation whose
Tagcloud (Intersection) ?