GNAI3 and PTPRU

Number of citations of the paper that reports this interaction (PubMedID 16298104)
0

Data Source:
HPRD (in vitro, in vivo)

		GNAI3	PTPRU
Description		G protein subunit alpha i3	protein tyrosine phosphatase receptor type U
Image
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Nucleolus Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Centrosome Cytosol Heterotrimeric G-protein Complex Cytoskeleton Plasma Membrane Membrane Midbody Centriolar Satellite Ciliary Basal Body Extracellular Exosome	Plasma Membrane Cell-cell Junction Membrane Anchoring Junction
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding Guanyl Nucleotide Binding GDP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Beta-catenin Binding Hydrolase Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Macroautophagy GTP Metabolic Process Cell Division	Protein Dephosphorylation Cell Adhesion Signal Transduction Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Negative Regulation Of Cell Population Proliferation Cell Differentiation Negative Regulation Of Cell Migration Animal Organ Regeneration Neuron Projection Development Homotypic Cell-cell Adhesion Protein Localization To Cell Surface Response To Glucocorticoid Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway ADP signalling through P2Y purinoceptor 12 G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production	Signaling by SCF-KIT
Drugs
Diseases
GWAS		Childhood body mass index ( 33045005) Major depressive disorder ( 20125088)	Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Bipolar disorder and schizophrenia ( 20889312) Blood protein levels ( 30072576) Carotid plaque maximum area ( 32469969) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol levels ( 32203549) Mean area of carotid plaque ( 32469969) Mean corpuscular volume ( 32888494) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Schizophrenia ( 28991256) Tourette syndrome ( 30818990)
Interacting Genes		45 interacting genes: AGTR2 ATP12A CCDC88A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 DVL1 GNB2 GNB4 GPSM1 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PCP2 PHF24 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SNCA SOX30 TSHR	12 interacting genes: CTNNB1 EGFR ERBB2 GNAI1 GNAI2 GNAI3 GNAO1 IRS1 KIT OMG OSTN PPFIA3
Entrez ID		2773	10076
HPRD ID		00765	03908
Ensembl ID		ENSG00000065135	ENSG00000060656
Uniprot IDs		P08754	Q92729
PDB IDs		2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S 7E9H 7KH0 7RA3 7RGP 7T10 7T11 7X6I 8GVX 8JD6 8K9L 8OY1 8SZH 8SZI 8WGB 9AVL	6SUB 6SUC
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway G-protein Alpha-subunit Binding Signal Transduction Regulation Of G Protein-coupled Receptor Signaling Pathway Plasma Membrane GTPase Activity GTPase Activator Activity Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling GTPase Regulator Activity GDP-dissociation Inhibitor Activity G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Membrane Synapse Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Guanyl-nucleotide Exchange Factor Activity Dendrite Regulation Of GTPase Activity Cytoplasm Melatonin Receptor Activity Dendritic Spine Response To Amphetamine Positive Regulation Of GTPase Activity Signaling Receptor Complex Adaptor Activity Glutamatergic Synapse Dopamine Uptake Involved In Synaptic Transmission Cell-cell Signaling Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Dopamine Uptake Involved In Synaptic Transmission Signaling Response To Amine Positive Regulation Of Hydrolase Activity Cell Communication Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Intracellular Signaling Cassette Presynapse Catecholamine Uptake Dopamine Uptake Visual Learning Presynaptic Membrane Regulation Of Blood Circulation Visual Behavior	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Ciliary Basal Body Negative Regulation Of Insulin Secretion Negative Regulation Of Secretion By Cell Adenylate Cyclase Regulator Activity Negative Regulation Of Peptide Secretion Negative Regulation Of Secretion Transmembrane Receptor Protein Tyrosine Kinase Activity Midbody Negative Regulation Of Transport Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway ERBB2-EGFR Signaling Pathway ERBB Signaling Pathway Plasma Membrane Basolateral Plasma Membrane Cell Surface Receptor Signaling Pathway Negative Regulation Of Hormone Secretion G Protein-coupled Receptor Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Negative Regulation Of Protein Secretion Negative Regulation Of Adenylate Cyclase Activity Regulation Of Protein Localization Positive Regulation Of Cell Population Proliferation Presynaptic Active Zone Cytoplasmic Component Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Kinase Binding GTPase Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Transport Nucleotide Binding Protein Tyrosine Kinase Activity G Protein-coupled Serotonin Receptor Signaling Pathway Signal Transduction GTP Binding Cell Population Proliferation Presynaptic Membrane ERBB2 Signaling Pathway Negative Regulation Of Establishment Of Protein Localization Signaling Receptor Binding Regulation Of Cell Communication
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