GNAI3 and RGS5

Number of citations of the paper that reports this interaction (PubMedID 9079700)
0

Data Source:
HPRD (in vitro)

		GNAI3	RGS5
Description		G protein subunit alpha i3	regulator of G protein signaling 5
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GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Nucleolus Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Centrosome Cytosol Heterotrimeric G-protein Complex Cytoskeleton Plasma Membrane Membrane Midbody Centriolar Satellite Ciliary Basal Body Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding Guanyl Nucleotide Binding GDP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	GTPase Activity GTPase Activator Activity Protein Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Macroautophagy GTP Metabolic Process Cell Division	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways		Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway ADP signalling through P2Y purinoceptor 12 G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production	G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events
Drugs
Diseases
GWAS		Childhood body mass index ( 33045005) Major depressive disorder ( 20125088)	Height ( 28552196) Hypoalbuminemia ( 34050200) Lead levels in blood ( 25820613) Liver enzyme levels (alanine transaminase) ( 24124411) Motion sickness ( 25628336) Response to mTOR inhibitor (rapamycin) ( 24009623)
Interacting Genes		45 interacting genes: AGTR2 ATP12A CCDC88A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 DVL1 GNB2 GNB4 GPSM1 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PCP2 PHF24 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SNCA SOX30 TSHR	7 interacting genes: ADRB2 APP GNAI2 GNAI3 GNAO1 GNAQ MEOX2
Entrez ID		2773	8490
HPRD ID		00765	04471
Ensembl ID		ENSG00000065135	ENSG00000143248
Uniprot IDs		P08754	O15539
PDB IDs		2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S 7E9H 7KH0 7RA3 7RGP 7T10 7T11 7X6I 8GVX 8JD6 8K9L 8OY1 8SZH 8SZI 8WGB 9AVL	2CRP
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway G-protein Alpha-subunit Binding Signal Transduction Regulation Of G Protein-coupled Receptor Signaling Pathway Plasma Membrane GTPase Activity GTPase Activator Activity Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling GTPase Regulator Activity GDP-dissociation Inhibitor Activity G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Membrane Synapse Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Guanyl-nucleotide Exchange Factor Activity Dendrite Regulation Of GTPase Activity Cytoplasm Melatonin Receptor Activity Dendritic Spine Response To Amphetamine Positive Regulation Of GTPase Activity Signaling Receptor Complex Adaptor Activity Glutamatergic Synapse Dopamine Uptake Involved In Synaptic Transmission Cell-cell Signaling Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Dopamine Uptake Involved In Synaptic Transmission Signaling Response To Amine Positive Regulation Of Hydrolase Activity Cell Communication Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Intracellular Signaling Cassette Presynapse Catecholamine Uptake Dopamine Uptake Visual Learning Presynaptic Membrane Regulation Of Blood Circulation Visual Behavior	Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex G Protein-coupled Receptor Binding Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Neuronal Dense Core Vesicle Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Cell Body GTPase Activity GTP Binding Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of CAMP/PKA Signal Transduction Modulation Of Chemical Synaptic Transmission Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Superoxide Anion Generation Positive Regulation Of Superoxide Anion Generation G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Superoxide Metabolic Process Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Ligand-gated Ion Channel Signaling Pathway Acetylcholine Receptor Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Modulation Of Excitatory Postsynaptic Potential Postsynaptic Signal Transduction Cellular Response To Amyloid-beta Ciliary Basal Body Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Response To Amyloid-beta Regulation Of Metal Ion Transport Regulation Of Multicellular Organism Growth Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway G Protein Activity Regulation Of Monoatomic Ion Transport Positive Regulation Of MAPK Cascade Dendrite Positive Regulation Of Macroautophagy Beta2-adrenergic Receptor Activity Acetylcholine Receptor Activator Activity
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