GNAI3 and RIC8A

Number of citations of the paper that reports this interaction (PubMedID 12509430)
0

Data Source:
HPRD (two hybrid, in vitro)

		GNAI3	RIC8A
Description		G protein subunit alpha i3	RIC8 guanine nucleotide exchange factor A
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Nucleolus Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Centrosome Cytosol Heterotrimeric G-protein Complex Cytoskeleton Plasma Membrane Membrane Midbody Centriolar Satellite Ciliary Basal Body Extracellular Exosome	Cytoplasm Plasma Membrane Cell Cortex Membrane
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding Guanyl Nucleotide Binding GDP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	G-protein Alpha-subunit Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Folding Chaperone
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Macroautophagy GTP Metabolic Process Cell Division	In Utero Embryonic Development Vasculature Development Protein Folding G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Gastrulation Visual Learning Response To Light Stimulus Cell Migration Involved In Gastrulation Cell-cell Adhesion Involved In Gastrulation Basement Membrane Organization
Pathways		Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway ADP signalling through P2Y purinoceptor 12 G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production
Drugs
Diseases
GWAS		Childhood body mass index ( 33045005) Major depressive disorder ( 20125088)	Cataracts ( 34127677) Cataracts (operation) ( 31816047) Gynecologic disease ( 31488892) Gynecologic disease (multivariate analysis) ( 31488892) Mean corpuscular hemoglobin concentration ( 29403010) Meningioma ( 29762745) Platelet count ( 24026423) Uterine fibroids ( 21460842 31488892 31649266) Uterine fibroids (MTAG) ( 31488892)
Interacting Genes		45 interacting genes: AGTR2 ATP12A CCDC88A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 DVL1 GNB2 GNB4 GPSM1 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PCP2 PHF24 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SNCA SOX30 TSHR	27 interacting genes: ATP1A4 EFEMP1 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS MAPK8IP3 MID1 NECAB2 NUTM1 OGT PACSIN2 PDE4B RABAC1 SDCBP SH3GLB1 SLC2A13 TERF1 TUBB2A UBQLN1 UBQLN4 XPO1 ZDHHC17 ZNF585B
Entrez ID		2773	60626
HPRD ID		00765	12373
Ensembl ID		ENSG00000065135	ENSG00000177963
Uniprot IDs		P08754	Q9NPQ8
PDB IDs		2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S 7E9H 7KH0 7RA3 7RGP 7T10 7T11 7X6I 8GVX 8JD6 8K9L 8OY1 8SZH 8SZI 8WGB 9AVL
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway G-protein Alpha-subunit Binding Signal Transduction Regulation Of G Protein-coupled Receptor Signaling Pathway Plasma Membrane GTPase Activity GTPase Activator Activity Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling GTPase Regulator Activity GDP-dissociation Inhibitor Activity G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Membrane Synapse Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Guanyl-nucleotide Exchange Factor Activity Dendrite Regulation Of GTPase Activity Cytoplasm Melatonin Receptor Activity Dendritic Spine Response To Amphetamine Positive Regulation Of GTPase Activity Signaling Receptor Complex Adaptor Activity Glutamatergic Synapse Dopamine Uptake Involved In Synaptic Transmission Cell-cell Signaling Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Dopamine Uptake Involved In Synaptic Transmission Signaling Response To Amine Positive Regulation Of Hydrolase Activity Cell Communication Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Intracellular Signaling Cassette Presynapse Catecholamine Uptake Dopamine Uptake Visual Learning Presynaptic Membrane Regulation Of Blood Circulation Visual Behavior	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Adenylate Cyclase Regulator Activity GTPase Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway GTP Binding G Protein Activity G Protein-coupled Receptor Binding Mu-type Opioid Receptor Binding Cytoplasm Negative Regulation Of Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Cell Body Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Prostaglandin E Corticotropin-releasing Hormone Receptor 1 Binding Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Cellular Component Organization Cytoplasmic Vesicle Regulation Of Cell Communication Centriolar Satellite Regulation Of Protein Localization Regulation Of Signaling Plasma Membrane Regulation Of Transport Negative Regulation Of Cellular Component Organization Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Golgi Apparatus Regulation Of Establishment Of Protein Localization G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Endocytosis Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Midbody Identical Protein Binding Regulation Of Macroautophagy Regulation Of Relaxation Of Muscle Negative Regulation Of Receptor Internalization Regulation Of Proteasomal Protein Catabolic Process Extracellular Vesicle Cellular Response To Acidic PH Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of MAPK Cascade Cell Projection G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction
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