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GNAI3 and RGS19
Number of citations of the paper that reports this interaction (PubMedID
8986788
)
56
Data Source:
HPRD
(two hybrid, in vitro, in vivo)
GNAI3
RGS19
Description
G protein subunit alpha i3
regulator of G protein signaling 19
Image
GO Annotations
Cellular Component
Golgi Membrane
Nucleoplasm
Nucleolus
Cytoplasm
Lysosomal Membrane
Endoplasmic Reticulum Membrane
Golgi Apparatus
Centrosome
Cytosol
Heterotrimeric G-protein Complex
Cytoskeleton
Plasma Membrane
Membrane
Midbody
Centriolar Satellite
Ciliary Basal Body
Extracellular Exosome
Golgi Apparatus
Plasma Membrane
Membrane
Molecular Function
Nucleotide Binding
G Protein-coupled Receptor Binding
GTPase Activity
Protein Binding
GTP Binding
Guanyl Nucleotide Binding
GDP Binding
G-protein Beta/gamma-subunit Complex Binding
Metal Ion Binding
GTPase Activity
Protein Binding
Biological Process
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of Adenylate Cyclase Activity
Positive Regulation Of Macroautophagy
GTP Metabolic Process
Cell Division
Autophagy
G Protein-coupled Receptor Signaling Pathway
Small GTPase-mediated Signal Transduction
Negative Regulation Of Signal Transduction
Pathways
Adenylate cyclase inhibitory pathway
Adenylate cyclase inhibitory pathway
ADP signalling through P2Y purinoceptor 12
G alpha (s) signalling events
G alpha (i) signalling events
G alpha (i) signalling events
G alpha (z) signalling events
Extra-nuclear estrogen signaling
GPER1 signaling
ADORA2B mediated anti-inflammatory cytokines production
G alpha (q) signalling events
G alpha (i) signalling events
G alpha (i) signalling events
G alpha (z) signalling events
Drugs
Diseases
GWAS
Childhood body mass index (
33045005
)
Major depressive disorder (
20125088
)
Cerebrospinal AB1-42 levels in normal cognition (
29274321
)
Chronic kidney disease (
31152163
)
Coronary artery disease (
33020668
)
Estimated glomerular filtration rate (
31152163
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
27863252
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Systolic blood pressure (
30578418
)
Interacting Genes
45 interacting genes:
AGTR2
ATP12A
CCDC88A
CCDC88C
CCR5
CD48
CD59
CNR1
CXCR2
DRD2
DVL1
GNB2
GNB4
GPSM1
GPSM2
GPSM3
HTR1A
LPAR1
MTNR1A
MTNR1B
NGB
NUCB1
NUCB2
PCP2
PHF24
PRKAR2B
PTPRU
RANGAP1
RGS10
RGS12
RGS14
RGS16
RGS17
RGS18
RGS19
RGS2
RGS20
RGS3
RGS5
RGS7
RIC8A
S1PR1
SNCA
SOX30
TSHR
26 interacting genes:
ALPP
CATSPER1
CSNK2A1
CSNK2A2
GDE1
GIPC1
GNAI1
GNAI2
GNAI3
GNAO1
GNAZ
HINT1
HOXA1
KRTAP5-6
LCE4A
MAPK1
MAPK6
NUFIP2
OPRL1
OSTM1
OTX1
POU4F2
PRKCA
PSMA1
TGFBR1
VASN
Entrez ID
2773
10287
HPRD ID
00765
05461
Ensembl ID
ENSG00000065135
ENSG00000171700
Uniprot IDs
P08754
B4DP94
P49795
PDB IDs
2IHB
2ODE
2V4Z
4G5O
4G5R
4G5S
7E9H
7KH0
7RA3
7RGP
7T10
7T11
7X6I
8GVX
8JD6
8K9L
8OY1
8SZH
8SZI
8WGB
9AVL
1CMZ
Enriched GO Terms of Interacting Partners
?
G Protein-coupled Receptor Signaling Pathway
G-protein Alpha-subunit Binding
Signal Transduction
Regulation Of G Protein-coupled Receptor Signaling Pathway
Plasma Membrane
GTPase Activity
GTPase Activator Activity
Negative Regulation Of Signal Transduction
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
GTPase Regulator Activity
GDP-dissociation Inhibitor Activity
G Protein-coupled Receptor Activity
G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
Regulation Of Signal Transduction
Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway
Regulation Of Cell Communication
Regulation Of Signaling
Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
Membrane
Synapse
Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Guanyl-nucleotide Exchange Factor Activity
Dendrite
Regulation Of GTPase Activity
Cytoplasm
Melatonin Receptor Activity
Dendritic Spine
Response To Amphetamine
Positive Regulation Of GTPase Activity
Signaling Receptor Complex Adaptor Activity
Glutamatergic Synapse
Dopamine Uptake Involved In Synaptic Transmission
Cell-cell Signaling
Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure
Regulation Of Dopamine Uptake Involved In Synaptic Transmission
Signaling
Response To Amine
Positive Regulation Of Hydrolase Activity
Cell Communication
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Intracellular Signaling Cassette
Presynapse
Catecholamine Uptake
Dopamine Uptake
Visual Learning
Presynaptic Membrane
Regulation Of Blood Circulation
Visual Behavior
Guanyl Nucleotide Binding
G-protein Beta/gamma-subunit Complex Binding
Heterotrimeric G-protein Complex
Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Serotonin Receptor Binding
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
Nucleotide Binding
G Protein-coupled Receptor Binding
G Protein-coupled Serotonin Receptor Signaling Pathway
Protein Kinase CK2 Complex
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase Inhibitor Activity
Adenylate Cyclase Regulator Activity
Protein Serine/threonine Kinase Activity
Negative Regulation Of Insulin Secretion
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Peptide Secretion
Negative Regulation Of Secretion By Cell
Outer Ear Morphogenesis
Protein Kinase Activity
Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway
Ciliary Basal Body
Negative Regulation Of Adenylate Cyclase Activity
GTPase Activity
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Insulin Secretion
Negative Regulation Of Secretion
Negative Regulation Of Hormone Secretion
Protein Serine Kinase Activity
GTP Binding
Negative Regulation Of Protein Secretion
Regulation Of Peptide Hormone Secretion
Negative Regulation Of Proteolysis Involved In Protein Catabolic Process
Cell Body
Kinase Activity
MAP Kinase Activity
Apoptotic Process
Cell Death
Signal Transduction
Programmed Cell Death
Negative Regulation Of Apoptotic Signaling Pathway
Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Transforming Growth Factor Beta Binding
Positive Regulation Of Cholesterol Biosynthetic Process
Regulation Of Hormone Secretion
Regulation Of Protein Secretion
Plasma Membrane
PcG Protein Complex
Negative Regulation Of Protein Catabolic Process
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Tagcloud (Intersection)
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