GNAI3 and LPAR1

Number of citations: 39 (PubMedID 9600933)
Data Source: HPRD (in vitro)

		GNAI3	LPAR1
Name		G protein subunit alpha i3	lysophosphatidic acid receptor 1
Structure
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Nucleolus Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Centrosome Cytosol Heterotrimeric G-protein Complex Cytoskeleton Plasma Membrane Membrane Midbody Centriolar Satellite Ciliary Basal Body Extracellular Exosome	Cytoplasm Endosome Plasma Membrane Cell Surface Membrane Endocytic Vesicle Presynaptic Membrane Neuronal Cell Body Dendritic Spine Dendritic Shaft Postsynaptic Membrane Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding Guanyl Nucleotide Binding GDP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Protein Binding Phospholipid Binding Lipid Binding PDZ Domain Binding Lysophosphatidic Acid Binding Lysophosphatidic Acid Receptor Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Macroautophagy GTP Metabolic Process Cell Division	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Cell Shape Negative Regulation Of Neuron Projection Development Oligodendrocyte Development Cerebellum Development Optic Nerve Development Neurogenesis Corpus Callosum Development Bleb Assembly Positive Regulation Of Rho Protein Signal Transduction Myelination Golgi To Plasma Membrane Protein Transport Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Cilium Assembly Positive Regulation Of Stress Fiber Assembly Cell Chemotaxis Regulation Of Vesicle-mediated Transport Positive Regulation Of Dendritic Spine Development Protein Localization To Cilium Cellular Response To Oxygen Levels Positive Regulation Of Smooth Muscle Cell Chemotaxis Regulation Of Synaptic Vesicle Cycle Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Cilium Assembly Cellular Response To 1-oleoyl-sn-glycerol 3-phosphate
Pathways		Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway ADP signalling through P2Y purinoceptor 12 G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production	G alpha (q) signalling events G alpha (i) signalling events Lysosphingolipid and LPA receptors
GWAS		Childhood body mass index ( 33045005 ) Major depressive disorder ( 20125088 )	Birth weight ( 27680694 31043758 ) Brain morphology (MOSTest) ( 32665545 ) Central corneal thickness ( 32528159 31798171 30894546 29760442 ) Corneal structure ( 23291589 ) Cortical thickness ( 32963231 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Eosinophil count ( 27863252 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 32888494 ) Height ( 31562340 25282103 20881960 ) Monocyte count ( 28031487 28193307 29403010 32888494 ) Monocyte percentage of white cells ( 32888494 ) Neutrophil percentage of granulocytes ( 27863252 ) Offspring birth weight ( 31043758 ) Post bronchodilator FEV1 in COPD ( 26634245 ) Pursuit maintenance gain ( 29064472 ) Sum eosinophil basophil counts ( 27863252 ) White blood cell count (monocyte) ( 28158719 ) White matter hyperintensity volume ( 33293549 ) White matter hyperintensity volume (adjusted for hypertension) ( 33293549 ) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549 )
Interacting Genes		45 interacting genes: AGTR2 ATP12A CCDC88A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 DVL1 GNB2 GNB4 GPSM1 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PCP2 PHF24 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SNCA SOX30 TSHR	7 interacting genes: ARHGEF11 ARHGEF12 DRD2 GIPC1 GNAI3 KRAS NHERF2
Entrez ID		2773	1902
HPRD ID		00765	03790
Ensembl ID		ENSG00000065135	ENSG00000198121
Uniprot IDs		P08754	Q5VZX0 Q6GPG7 Q92633
PDB IDs		2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S 7E9H 7KH0 7RA3 7RGP 7T10 7T11 7X6I 8GVX 8JD6 8K9L 8OY1 8SZH 8SZI 8WGB 9AVL	4Z34 4Z35 4Z36 7TD0 7TD1 7TD2 7YU3 7YU4 7YU5 7YU6 7YU7 7YU8 9IZF 9IZG 9IZH 9J5V
GO Terms Enriched among Interactors		G Protein-coupled Receptor Signaling Pathway G-protein Alpha-subunit Binding Signal Transduction Regulation Of G Protein-coupled Receptor Signaling Pathway Plasma Membrane GTPase Activity GTPase Activator Activity Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling GTPase Regulator Activity GDP-dissociation Inhibitor Activity G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Membrane Synapse Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Guanyl-nucleotide Exchange Factor Activity Dendrite Regulation Of GTPase Activity Cytoplasm Melatonin Receptor Activity Dendritic Spine Response To Amphetamine Positive Regulation Of GTPase Activity Signaling Receptor Complex Adaptor Activity Glutamatergic Synapse Dopamine Uptake Involved In Synaptic Transmission Cell-cell Signaling Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Dopamine Uptake Involved In Synaptic Transmission Signaling Response To Amine Positive Regulation Of Hydrolase Activity Cell Communication Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Intracellular Signaling Cassette Presynapse Catecholamine Uptake Dopamine Uptake Visual Learning Presynaptic Membrane Regulation Of Blood Circulation Visual Behavior	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Binding Regulation Of Synaptic Transmission, GABAergic Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synaptic Plasticity Protein-membrane Adaptor Activity Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cytokinesis Small GTPase-mediated Signal Transduction Intracellular Signaling Cassette Visual Learning Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Neuronal Synaptic Plasticity Visual Behavior Rho Protein Signal Transduction Signaling Receptor Binding GDP Binding Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Cytokinesis Positive Regulation Of Cell Division Associative Learning Modulation Of Chemical Synaptic Transmission G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Type 2 Metabotropic Glutamate Receptor Binding Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Negative Regulation Of Dopamine Receptor Signaling Pathway GMP Binding Forebrain Astrocyte Development Type 3 Metabotropic Glutamate Receptor Binding Signal Transduction Membrane Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Golgi Membrane Positive Regulation Of Renal Sodium Excretion Negative Regulation Of Dopamine Secretion Dendritic Spine Response To Isolation Stress Learning Morphogenesis Of A Branching Structure Dopamine Binding Dopamine Neurotransmitter Receptor Activity Cerebral Cortex GABAergic Interneuron Migration Dopamine Uptake Involved In Synaptic Transmission Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Dephosphorylation Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Hyaloid Vascular Plexus Regression