GNAI3 and RGS7

Number of citations of the paper that reports this interaction (PubMedID 10092682)
0

Data Source:
HPRD (in vitro)

		GNAI3	RGS7
Description		G protein subunit alpha i3	regulator of G protein signaling 7
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GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Nucleolus Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Centrosome Cytosol Heterotrimeric G-protein Complex Cytoskeleton Plasma Membrane Membrane Midbody Centriolar Satellite Ciliary Basal Body Extracellular Exosome	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Dendrite Presynaptic Membrane Neuron Projection Dendrite Terminus Postsynaptic Membrane Cell Tip Presynapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding Guanyl Nucleotide Binding GDP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity G-protein Beta-subunit Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Macroautophagy GTP Metabolic Process Cell Division	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of GTPase Activity Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Postsynaptic Membrane Potential
Pathways		Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway ADP signalling through P2Y purinoceptor 12 G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production	G alpha (i) signalling events G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs
Diseases
GWAS		Childhood body mass index ( 33045005) Major depressive disorder ( 20125088)	Chronotype ( 30696823) Diastolic blood pressure ( 29208002) Longevity (90 years and older) ( 25199915) Major depressive disorder ( 27479909) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Western dietary pattern ( 28644415)
Interacting Genes		45 interacting genes: AGTR2 ATP12A CCDC88A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 DVL1 GNB2 GNB4 GPSM1 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PCP2 PHF24 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SNCA SOX30 TSHR	16 interacting genes: CHRM1 CHRM2 CHRM3 CHRM5 GNAI1 GNAI3 GNAO1 GNAQ GNAZ GNB5 MSX1 PKD1 PRKCA SNAPIN YWHAB YWHAQ
Entrez ID		2773	6000
HPRD ID		00765	03948
Ensembl ID		ENSG00000065135	ENSG00000182901
Uniprot IDs		P08754	A0A8I5KUA7 A0A8I5KXW5 A0A8I5KZ50 A0A8I5QJU0 B7Z257 P49802
PDB IDs		2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S 7E9H 7KH0 7RA3 7RGP 7T10 7T11 7X6I 8GVX 8JD6 8K9L 8OY1 8SZH 8SZI 8WGB 9AVL	2A72 2D9J 7EWP 7EWR 7SHF
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway G-protein Alpha-subunit Binding Signal Transduction Regulation Of G Protein-coupled Receptor Signaling Pathway Plasma Membrane GTPase Activity GTPase Activator Activity Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling GTPase Regulator Activity GDP-dissociation Inhibitor Activity G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Membrane Synapse Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Guanyl-nucleotide Exchange Factor Activity Dendrite Regulation Of GTPase Activity Cytoplasm Melatonin Receptor Activity Dendritic Spine Response To Amphetamine Positive Regulation Of GTPase Activity Signaling Receptor Complex Adaptor Activity Glutamatergic Synapse Dopamine Uptake Involved In Synaptic Transmission Cell-cell Signaling Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Dopamine Uptake Involved In Synaptic Transmission Signaling Response To Amine Positive Regulation Of Hydrolase Activity Cell Communication Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Intracellular Signaling Cassette Presynapse Catecholamine Uptake Dopamine Uptake Visual Learning Presynaptic Membrane Regulation Of Blood Circulation Visual Behavior	Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Heterotrimeric G-protein Complex G Protein-coupled Acetylcholine Receptor Activity Guanyl Nucleotide Binding G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Acetylcholine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Postsynaptic Signal Transduction G Protein-coupled Serotonin Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Postsynaptic Membrane Signal Transduction Regulation Of Protein Transport Dendrite G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Establishment Of Protein Localization GTPase Activity Regulation Of Transport Regulation Of Insulin Secretion G Protein-coupled Receptor Binding Synapse Regulation Of Peptide Hormone Secretion Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Negative Regulation Of Transport Regulation Of Hormone Secretion Regulation Of Protein Secretion Negative Regulation Of Protein Transport Adenylate Cyclase Inhibitor Activity Adenylate Cyclase Regulator Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Insulin Secretion Negative Regulation Of Establishment Of Protein Localization Chemical Synaptic Transmission Ciliary Basal Body Regulation Of Secretion By Cell Negative Regulation Of Peptide Secretion Regulation Of Protein Localization Saliva Secretion Trans-synaptic Signaling Synaptic Signaling Regulation Of Secretion GTP Binding Negative Regulation Of Hormone Secretion Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Regulation Of Biological Quality G Protein Activity
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