Wiki-Pi
About
Search
People
Updates
Search
KPNA2 and FN1
Number of citations of the paper that reports this interaction (PubMedID
19738201
)
40
Data Source:
BioGRID
(affinity chromatography technology, two hybrid)
KPNA2
FN1
Description
karyopherin subunit alpha 2
fibronectin 1
Image
GO Annotations
Cellular Component
Golgi Membrane
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Membrane
Nuclear Membrane
NLS-dependent Protein Nuclear Import Complex
Host Cell
Extracellular Region
Fibrinogen Complex
Basement Membrane
Extracellular Space
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum-Golgi Intermediate Compartment
Plasma Membrane
Apical Plasma Membrane
Extracellular Matrix
Platelet Alpha Granule Lumen
Extracellular Exosome
Blood Microparticle
Molecular Function
RNA Binding
Protein Binding
Nuclear Localization Sequence Binding
Histone Deacetylase Binding
Nuclear Import Signal Receptor Activity
Protease Binding
Signaling Receptor Binding
Integrin Binding
Extracellular Matrix Structural Constituent
Protein Binding
Collagen Binding
Heparin Binding
Peptidase Activator Activity
Identical Protein Binding
Proteoglycan Binding
Receptor Ligand Activity
Biological Process
Regulation Of DNA Recombination
DNA Metabolic Process
Protein Import Into Nucleus
NLS-bearing Protein Import Into Nucleus
Protein Transport
Positive Regulation Of Type I Interferon Production
Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of DNA-templated Transcription
Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin
Positive Regulation Of Viral Life Cycle
Angiogenesis
Regulation Of Protein Phosphorylation
Acute-phase Response
Cell-substrate Junction Assembly
Cell Adhesion
Cell-matrix Adhesion
Calcium-independent Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Nervous System Development
Heart Development
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Response To Wounding
Positive Regulation Of Gene Expression
Response To Muscle Activity
Integrin Activation
Substrate Adhesion-dependent Cell Spreading
Endodermal Cell Differentiation
Wound Healing
Endothelial Cell Migration
Positive Regulation Of Axon Extension
Positive Regulation Of Fibroblast Proliferation
Biological Process Involved In Interaction With Symbiont
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Transforming Growth Factor Beta Production
Blood Coagulation, Fibrin Clot Formation
Negative Regulation Of Monocyte Activation
Neural Crest Cell Migration Involved In Autonomic Nervous System Development
Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate
Pathways
CaMK IV-mediated phosphorylation of CREB
ISG15 antiviral mechanism
NS1 Mediated Effects on Host Pathways
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
Sensing of DNA Double Strand Breaks
Estrogen-dependent gene expression
SARS-CoV-1 activates/modulates innate immune responses
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Platelet degranulation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Fibronectin matrix formation
Cell surface interactions at the vascular wall
Molecules associated with elastic fibres
Integrin cell surface interactions
Syndecan interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
MAP2K and MAPK activation
Interleukin-4 and Interleukin-13 signaling
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
MET activates PTK2 signaling
Post-translational protein phosphorylation
GPER1 signaling
Attachment of bacteria to epithelial cells
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
ALK mutants bind TKIs
Signaling by ALK fusions and activated point mutants
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Developmental Lineage of Pancreatic Ductal Cells
Drugs
Zinc
Lanoteplase
Ocriplasmin
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
GWAS
Brain morphology (MOSTest) (
32665545
)
Feeling lonely (
29500382
)
General risk tolerance (MTAG) (
30643258
)
Loneliness (
29970889
)
Loneliness (MTAG) (
29970889
)
Refractive error (
32231278
)
Regular attendance at a religious group (
29970889
)
Apolipoprotein B levels (
32203549
)
Cholesterol, total (
26780889
)
Coronary artery disease (
33020668
32469254
29212778
28714974
)
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
Diastolic blood pressure (
30578418
)
Iron status biomarkers (ferritin levels) (
33536631
)
LDL cholesterol (
24097068
)
LDL cholesterol levels (
28334899
32203549
)
Lymphocyte count (
32888494
)
Monocyte count (
32888494
)
Myocardial infarction (
33532862
)
Negative urgency (
30718321
)
Pulse pressure (
30578418
28135244
27841878
)
Systolic blood pressure (
30578418
27841878
)
Total cholesterol levels (
28334899
)
White blood cell count (
32888494
)
Interacting Genes
111 interacting genes:
ACTN1
ACTN4
ANKIB1
AP2B1
APOBEC1
APP
ARL4A
ARL5A
ATXN3
BAG6
BRCA1
BTBD2
CASP2
CCDC107
CDA
CDC42
CDK5RAP3
CHD3
CHEK2
CORO1B
CREB3L3
CREBBP
CSNK1A1
CUL4B
DCPS
DCTN2
DDIT3
EIF4ENIF1
EP300
EPB41
FEZ2
FN1
FTH1
GART
GMCL1
GRB2
GTF2IRD1
H1-0
HAP1
HMG20A
HNRNPC
HOMER2
HOMEZ
HSPA4
IFT20
IMMT
INO80E
ITK
JUN
KLC4
KPNB1
KRT18
KRT40
KRT8
LAMB2
LEF1
LZTS2
MAGED1
MAGEH1
MDFI
MLH1
MORC3
MORF4L1
MVP
NECAB2
NFE2L2
NFKBIB
NMNAT1
NR3C1
NUP153
NUP50
NUP62
NUTM1
OGT
PAX5
PLAG1
PNMA5
PRKD3
PTMA
RAG1
RANBP2
RBM48
RBPMS
RECQL
RELA
RELB
RGL2
RILP
RNMT
SERTAD3
SGK1
SLC2A2
SPRY1
SRPK1
STUB1
SUMO2
TADA2A
TAF3
TAF8
TANK
TBPL2
TP53
TRAF1
TRIM54
TSC22D4
TXNIP
UBR5
USHBP1
ZBTB7B
ZC3H12A
ZNF131
111 interacting genes:
ADAMTS4
AMBP
ANOS1
APCS
ATXN10
ATXN7
C1QA
CCN3
CD44
CDKN2A
COL13A1
COL1A1
COL1A2
COL2A1
COL4A1
COL4A2
COL4A3
COL4A4
COL4A5
COL4A6
COL6A2
COL7A1
COL9A1
COMP
CRP
CTSD
CXCL12
DCN
DSCR9
DUSP10
EGFR
F13A1
FAM86B3P
FASLG
FBLN1
FBLN2
FST
FSTL3
GALNT6
GRB2
GSN
HGF
HOXA1
HRG
HSP90AA1
HSPG2
IGFBP3
IGFBP5
ITGA2B
ITGA3
ITGA4
ITGA5
ITGA8
ITGB1
ITGB3
ITGB6
ITGB7
KLK3
KPNA2
LACRT
LGALS3BP
LPA
LRG1
LTBP1
MAG
MATN2
MEP1A
MEP1B
MIA
MMP9
MTDH
MTNR1A
MYOC
NR0B2
NT5E
PELI2
PKD1
PLAT
PLG
PRELP
PRPF40A
RARA
RBL1
REG3A
RPS6KA5
RSPH1
SCGB1A1
SDC2
SGCA
SH3GLB1
SKIL
SMAD4
SMAD9
SPARC
STAT5A
TAB1
TAB2
TAC1
TGFBI
TGM2
THBS1
TIMD4
TLR4
TMPRSS6
TNC
TNFRSF11B
TSHR
TTN
UBQLN1
VEGFA
VHL
Entrez ID
3838
2335
HPRD ID
02818
00626
Ensembl ID
ENSG00000182481
ENSG00000115414
Uniprot IDs
P52292
B7ZLE5
P02751
Q9UQS6
PDB IDs
1EFX
1QGK
1QGR
3FEX
3FEY
3WPT
4E4V
4WV6
5H43
7CRU
7N8J
7N9H
8FZK
8GCN
1E88
1E8B
1FBR
1FNA
1FNF
1FNH
1J8K
1O9A
1OWW
1Q38
1QGB
1QO6
1TTF
1TTG
2CG6
2CG7
2CK2
2CKU
2EC3
2FN2
2FNB
2GEE
2H41
2H45
2HA1
2MNU
2N1K
2OCF
2RKY
2RKZ
2RL0
3CAL
3EJH
3GXE
3M7P
3MQL
3R8Q
3T1W
3ZRZ
4GH7
4JE4
4JEG
4LXO
4MMX
4MMY
4MMZ
4PZ5
5DC0
5DC4
5DC9
5DFT
5J6Z
5J7C
5M0A
5N47
5N48
6HNF
6MFA
6MSV
6NAJ
6XAX
6XAY
7NWL
8PEQ
Enriched GO Terms of Interacting Partners
?
Nucleus
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Metabolic Process
Identical Protein Binding
Regulation Of RNA Metabolic Process
Nucleoplasm
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of RNA Metabolic Process
Chromatin Organization
Regulation Of Programmed Cell Death
Negative Regulation Of Transcription By RNA Polymerase II
Ubiquitin Protein Ligase Binding
Intracellular Signal Transduction
DNA Damage Response
Cytoplasm
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Apoptotic Process
Regulation Of Signal Transduction
Negative Regulation Of Biosynthetic Process
Cytosol
Positive Regulation Of Response To Endoplasmic Reticulum Stress
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Transcription By RNA Polymerase II
Protein-containing Complex
Protein Binding
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Nuclear Inclusion Body
Positive Regulation Of Proteolysis
Regulation Of Protein Catabolic Process
Negative Regulation Of Catabolic Process
Regulation Of Transcription By RNA Polymerase II
Protein Import Into Nucleus
Extracellular Matrix
Extracellular Region
Extracellular Space
Extracellular Matrix Structural Constituent
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Fibronectin Binding
Extracellular Matrix Organization
Extracellular Structure Organization
Basement Membrane
Collagen Trimer
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Integrin Binding
Cell Adhesion
Endoplasmic Reticulum Lumen
Cell Surface
Developmental Process
Negative Regulation Of Multicellular Organismal Process
Collagen Type IV Trimer
Integrin Complex
Signal Transduction
Negative Regulation Of Developmental Process
Regulation Of Multicellular Organismal Process
Response To Growth Factor
Cell-matrix Adhesion
Regulation Of Cell Adhesion
Extracellular Matrix Binding
Anatomical Structure Morphogenesis
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Regulation Of Vasculature Development
Cell-cell Adhesion
Positive Regulation Of Cell Migration
Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Regulation Of Developmental Process
Regulation Of Multicellular Organismal Development
Positive Regulation Of Locomotion
Regulation Of Apoptotic Process
Collagen-activated Signaling Pathway
Regulation Of Angiogenesis
Regulation Of Cell Motility
Collagen Binding
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Cell-substrate Adhesion
Cell Adhesion Mediated By Integrin
Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of Programmed Cell Death
Regulation Of Cell Population Proliferation
Regulation Of Locomotion
Integrin-mediated Signaling Pathway
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?