KPNA2 and AP2B1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		KPNA2	AP2B1
Description		karyopherin subunit alpha 2	adaptor related protein complex 2 subunit beta 1
Image
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Nuclear Membrane NLS-dependent Protein Nuclear Import Complex Host Cell	Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Endomembrane System Membrane Membrane Coat Clathrin Coat AP-2 Adaptor Complex Clathrin Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Synapse Clathrin-coated Endocytic Vesicle Postsynaptic Endocytic Zone Extrinsic Component Of Presynaptic Endocytic Zone Membrane Glutamatergic Synapse
	Molecular Function	RNA Binding Protein Binding Nuclear Localization Sequence Binding Histone Deacetylase Binding Nuclear Import Signal Receptor Activity	Signal Sequence Binding Protein Binding Clathrin Binding Clathrin Adaptor Activity Protein-containing Complex Binding
	Biological Process	Regulation Of DNA Recombination DNA Metabolic Process Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Protein Transport Positive Regulation Of Type I Interferon Production Non-canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-templated Transcription Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Positive Regulation Of Viral Life Cycle	Kidney Development Cardiac Septum Development Ventricular Septum Development Intracellular Protein Transport Endocytosis Chemical Synaptic Transmission Neurotransmitter Secretion Heart Development Protein Transport Vesicle-mediated Transport Aorta Development Positive Regulation Of Endocytosis Clathrin Coat Assembly Synaptic Vesicle Endocytosis Coronary Vasculature Development Clathrin-dependent Endocytosis Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of Protein Localization To Membrane
Pathways		CaMK IV-mediated phosphorylation of CREB ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Sensing of DNA Double Strand Breaks Estrogen-dependent gene expression SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses	Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Feeling lonely ( 29500382) General risk tolerance (MTAG) ( 30643258) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889)	Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 22139419 27863252 32888494) Mean reticulocyte volume ( 32888494) Platelet count ( 22139419 27863252) Platelet distribution width ( 27863252) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		111 interacting genes: ACTN1 ACTN4 ANKIB1 AP2B1 APOBEC1 APP ARL4A ARL5A ATXN3 BAG6 BRCA1 BTBD2 CASP2 CCDC107 CDA CDC42 CDK5RAP3 CHD3 CHEK2 CORO1B CREB3L3 CREBBP CSNK1A1 CUL4B DCPS DCTN2 DDIT3 EIF4ENIF1 EP300 EPB41 FEZ2 FN1 FTH1 GART GMCL1 GRB2 GTF2IRD1 H1-0 HAP1 HMG20A HNRNPC HOMER2 HOMEZ HSPA4 IFT20 IMMT INO80E ITK JUN KLC4 KPNB1 KRT18 KRT40 KRT8 LAMB2 LEF1 LZTS2 MAGED1 MAGEH1 MDFI MLH1 MORC3 MORF4L1 MVP NECAB2 NFE2L2 NFKBIB NMNAT1 NR3C1 NUP153 NUP50 NUP62 NUTM1 OGT PAX5 PLAG1 PNMA5 PRKD3 PTMA RAG1 RANBP2 RBM48 RBPMS RECQL RELA RELB RGL2 RILP RNMT SERTAD3 SGK1 SLC2A2 SPRY1 SRPK1 STUB1 SUMO2 TADA2A TAF3 TAF8 TANK TBPL2 TP53 TRAF1 TRIM54 TSC22D4 TXNIP UBR5 USHBP1 ZBTB7B ZC3H12A ZNF131	60 interacting genes: - ACVR1 AFF4 AP1M1 AP1M2 AP2A2 AP2M1 AP2S1 APC ARF6 ARRB1 ATM ATP23 ATP6V1G1 BUB1 BUB1B CATSPERT CCDC187 CEBPA CLINT1 COL3A1 DHX58 DNAJC5 DSCAM FMNL2 GPANK1 GTF2I HIP1 HPCA HSPB1 KANK2 KIAA0408 KPNA2 LDLRAP1 LONRF1 MEA1 MLH1 NECAP2 NEU4 NUP54 PIP5K1C POM121 PSORS1C2 RAPGEF3 RIBC2 SLC25A6 SLC2A8 SMAD4 SMURF1 SNAP91 TENT5C TERF2IP TEX12 TGFBR1 TGFBR2 THAP1 TUBGCP4 TXN2 U2AF1 UBC
Entrez ID		3838	163
HPRD ID		02818	03015
Ensembl ID		ENSG00000182481	ENSG00000006125
Uniprot IDs		P52292	A0A140VJE8 P63010 Q96EL6
PDB IDs		1EFX 1QGK 1QGR 3FEX 3FEY 3WPT 4E4V 4WV6 5H43 7CRU 7N8J 7N9H 8FZK 8GCN	1E42 2G30 2IV8 2IV9 2JKR 2JKT 2VGL 2XA7 4UQI 5M5R 6QH5 6QH6 6QH7 6URI 6YAE 6YAF 6YAH 6YAI 7OG1 7OHO 7OM8 7Z5C
Enriched GO Terms of Interacting Partners?		Nucleus Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Identical Protein Binding Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Chromatin Organization Regulation Of Programmed Cell Death Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin Protein Ligase Binding Intracellular Signal Transduction DNA Damage Response Cytoplasm Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Regulation Of Signal Transduction Negative Regulation Of Biosynthetic Process Cytosol Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Intracellular Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Protein Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Nuclear Inclusion Body Positive Regulation Of Proteolysis Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus	Clathrin Adaptor Activity SMAD Binding Clathrin Adaptor Complex Clathrin-dependent Endocytosis Clathrin-coated Pit Synaptic Vesicle Endocytosis Regulation Of Receptor-mediated Endocytosis Presynaptic Endocytosis Endocytosis Clathrin Coat Assembly Vesicle-mediated Transport In Synapse Activin Receptor Complex Activin Receptor Activity, Type I Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Activin Receptor Signaling Pathway Receptor-mediated Endocytosis Mitotic Spindle Assembly Checkpoint Signaling Intracellular Protein Transport Clathrin-coated Endocytic Vesicle Membrane Negative Regulation Of Mitotic Metaphase/anaphase Transition Activin Binding Endocytic Vesicle Membrane AP-2 Adaptor Complex Receptor Internalization Clathrin-coated Vesicle Membrane Clathrin Binding Protein Transport Transmembrane Receptor Protein Serine/threonine Kinase Activity Clathrin-coated Vesicle Negative Regulation Of Chromosome Organization Ventricular Septum Morphogenesis Negative Regulation Of Mitotic Nuclear Division Positive Regulation Of SMAD Protein Signal Transduction Import Into Cell Regulation Of Endocytosis Vesicle-mediated Transport I-SMAD Binding Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA-dependent Protein Kinase Activity Transforming Growth Factor Beta Ligand-receptor Complex Transforming Growth Factor Beta Receptor Signaling Pathway Endolysosome Membrane Positive Regulation Of Receptor-mediated Endocytosis Transforming Growth Factor Beta Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Cellular Component Organization Establishment Of Protein Localization Positive Regulation Of Cellular Component Organization Intracellular Protein Localization
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