KPNA2 and NUP50

Number of citations of the paper that reports this interaction (PMID 12176322)
30

Data Source:
HPRD (in vitro)

		KPNA2	NUP50
Gene Name		karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	nucleoporin 50kDa
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane	Nuclear Pore Nucleoplasm Cytoplasm Nuclear Membrane
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Protein Transporter Activity Histone Deacetylase Binding Poly(A) RNA Binding	Protein Binding
	Biological Process	Regulation Of DNA Recombination DNA Metabolic Process NLS-bearing Protein Import Into Nucleus Viral Process Cytokine-mediated Signaling Pathway	Mitotic Cell Cycle Carbohydrate Metabolic Process Mitotic Nuclear Envelope Disassembly Hexose Transport Pathogenesis Gene Expression Regulation Of Glucose Transport Protein Transport Glucose Transport Viral Process Viral Life Cycle Viral Transcription Cytokine-mediated Signaling Pathway Small Molecule Metabolic Process Intracellular Transport MRNA Transport Transmembrane Transport
Pathways		ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes	Mitotic Prophase HIV Infection Nuclear import of Rev protein Regulatory RNA pathways Rev-mediated nuclear export of HIV RNA Nuclear Envelope Breakdown SLC-mediated transmembrane transport M Phase Influenza Life Cycle HIV Life Cycle Influenza Viral RNA Transcription and Replication Rev-mediated nuclear export of HIV RNA Myoclonic epilepsy of Lafora Glycogen storage diseases Transcriptional regulation by small RNAs Vpr-mediated nuclear import of PICs ISG15 antiviral mechanism Interferon Signaling Host Interactions of HIV factors Nuclear Pore Complex (NPC) Disassembly Regulation of Glucokinase by Glucokinase Regulatory Protein Cytokine Signaling in Immune system Interactions of Vpr with host cellular proteins Interactions of Rev with host cellular proteins Influenza Infection Hexose transport Cell Cycle, Mitotic Late Phase of HIV Life Cycle Antiviral mechanism by IFN-stimulated genes Viral Messenger RNA Synthesis Metabolism of carbohydrates Glucose transport
Drugs
Diseases
GWAS
Protein-Protein Interactions		104 interactors: ACTN1 ACTN4 ANKIB1 AP2B1 APOBEC1 APP ARL4A ARL5A BRCA1 BTBD2 CASP2 CCDC107 CDA CDK5RAP3 CHD3 CHEK2 CORO1B CREB3L3 CREBBP CSE1L CSNK1A1 CUL4B DCTN2 DDIT3 EP300 EPB41 FEZ2 FN1 FTH1 GART GMCL1 GRB2 H1F0 HAP1 HMG20A HNRNPC HOMER2 HOMEZ HSPA4 IFT20 IMMT INO80E ITK JUN KLC4 KPNB1 KRT18 KRT40 KRT8 LAMB2 LEF1 LZTS2 MAGED1 MAGEH1 MDFI MLH1 MORC3 MVP MYC NECAB2 NFKBIB NMNAT1 NR3C1 NUP153 NUP50 NUP62 NUTM1 PAX5 PLAG1 PNMA5 PRKD3 PTMA RAG1 RAN RANBP2 RBM48 RBPMS RECQL RELA RELB RGL2 RILP RNMT SART3 SERTAD3 SGK1 SLC2A2 SPRY1 SRPK1 TADA2A TAF3 TAF8 TANK TBPL2 TP53 TRAF1 TRIM54 TSC22D4 TXNIP UBR5 USHBP1 ZBTB7B ZC3H12A ZNF131	13 interactors: APP CDKN1B IPO13 KPNA1 KPNA2 KPNA3 KPNA4 KPNA5 KPNA6 KPNB1 RAN SRPK2 XPO1
Entrez ID		3838	10762
HPRD ID		02818	05226
Ensembl ID		ENSG00000182481	ENSG00000093000
Uniprot IDs		P52292 Q7Z726	Q9UKX7
PDB IDs		1EFX 1QGK 1QGR 3FEX 3FEY 4E4V	2EC1 3TJ3
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Cellular Process RNA Biosynthetic Process Gene Expression Response To Stimulus Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Cell Death Death Apoptotic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process Programmed Cell Death Viral Process Organelle Organization Regulation Of Nucleic Acid-templated Transcription Signal Transduction Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Developmental Process Regulation Of Transcription, DNA-templated Signaling Positive Regulation Of Transcription, DNA-templated Protein Localization To Nucleus Macromolecule Biosynthetic Process Cellular Localization Cell Cycle Negative Regulation Of Biosynthetic Process Cell Communication Negative Regulation Of Nucleic Acid-templated Transcription Cellular Process Negative Regulation Of RNA Biosynthetic Process Cell Cycle Process Response To Stress Positive Regulation Of Gene Expression Nucleocytoplasmic Transport Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Nuclear Transport Positive Regulation Of Macromolecule Biosynthetic Process Multicellular Organismal Development	Protein Localization To Nucleus NLS-bearing Protein Import Into Nucleus Protein Import Into Nucleus Nuclear Import Nucleocytoplasmic Transport Nuclear Transport Protein Import Protein Localization To Organelle Establishment Of Protein Localization To Organelle Cytoplasmic Transport Protein Targeting Intracellular Protein Transport Intracellular Transport Of Virus Intracellular Transport Cellular Protein Localization Establishment Of Localization In Cell Protein Transport Establishment Of Protein Localization Cellular Localization Protein Localization Viral Life Cycle Cytokine-mediated Signaling Pathway Transport Viral Process Cellular Response To Cytokine Stimulus Ribosomal Small Subunit Export From Nucleus Response To Cytokine Cellular Response To Organic Substance Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Ribosomal Large Subunit Export From Nucleus Cell Communication Ribosomal Subunit Export From Nucleus Response To Organic Substance Cellular Response To Stimulus Apoptotic DNA Fragmentation Apoptotic Nuclear Changes Protein Export From Nucleus Response To Stimulus Positive Regulation Of Cell Cycle Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Nuclear Speck Organization Regulation Of DNA Recombination Ribonucleoprotein Complex Biogenesis Execution Phase Of Apoptosis Synaptic Growth At Neuromuscular Junction Viral Penetration Into Host Nucleus DNA Catabolic Process, Endonucleolytic Regulation Of Cell Cycle
Tagcloud ?		aggressive aggressiveness assembled attempt carcinomas curable diagnostics disregarding eic emgd endometrial entities figo immunoreactivity interplay introducing malignancy mediator mfe microarrays nucleocytoplasmic precancerous regimens surgically tmas trp53 tumour untreatable uterus	accompany als amyotrophic cytosolic degenerating deleterious deregulation disrupted dominantly drosophila elicited flies hey histopathologic inherited intercellular lifespan microarrays misregulation neurotoxicity notch nucleoporin paradigms paralysis signature spindleb tardbp tdp widespread
Tagcloud (Difference) ?		aggressive aggressiveness assembled attempt carcinomas curable diagnostics disregarding eic emgd endometrial entities figo immunoreactivity interplay introducing malignancy mediator mfe nucleocytoplasmic precancerous regimens surgically tmas trp53 tumour untreatable uterus	accompany als amyotrophic cytosolic degenerating deleterious deregulation disrupted dominantly drosophila elicited flies hey histopathologic inherited intercellular lifespan misregulation neurotoxicity notch nucleoporin paradigms paralysis signature spindleb tardbp tdp widespread
Tagcloud (Intersection) ?		microarrays