KPNA2 and RGL2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		KPNA2	RGL2
Description		karyopherin subunit alpha 2	ral guanine nucleotide dissociation stimulator like 2
Image
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Nuclear Membrane NLS-dependent Protein Nuclear Import Complex Host Cell	Cytosol
	Molecular Function	RNA Binding Protein Binding Nuclear Localization Sequence Binding Histone Deacetylase Binding Nuclear Import Signal Receptor Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Regulation Of DNA Recombination DNA Metabolic Process Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Protein Transport Positive Regulation Of Type I Interferon Production Non-canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-templated Transcription Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Positive Regulation Of Viral Life Cycle	Signal Transduction Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Ral Protein Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		CaMK IV-mediated phosphorylation of CREB ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Sensing of DNA Double Strand Breaks Estrogen-dependent gene expression SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses	RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Feeling lonely ( 29500382) General risk tolerance (MTAG) ( 30643258) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889)	Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		111 interacting genes: ACTN1 ACTN4 ANKIB1 AP2B1 APOBEC1 APP ARL4A ARL5A ATXN3 BAG6 BRCA1 BTBD2 CASP2 CCDC107 CDA CDC42 CDK5RAP3 CHD3 CHEK2 CORO1B CREB3L3 CREBBP CSNK1A1 CUL4B DCPS DCTN2 DDIT3 EIF4ENIF1 EP300 EPB41 FEZ2 FN1 FTH1 GART GMCL1 GRB2 GTF2IRD1 H1-0 HAP1 HMG20A HNRNPC HOMER2 HOMEZ HSPA4 IFT20 IMMT INO80E ITK JUN KLC4 KPNB1 KRT18 KRT40 KRT8 LAMB2 LEF1 LZTS2 MAGED1 MAGEH1 MDFI MLH1 MORC3 MORF4L1 MVP NECAB2 NFE2L2 NFKBIB NMNAT1 NR3C1 NUP153 NUP50 NUP62 NUTM1 OGT PAX5 PLAG1 PNMA5 PRKD3 PTMA RAG1 RANBP2 RBM48 RBPMS RECQL RELA RELB RGL2 RILP RNMT SERTAD3 SGK1 SLC2A2 SPRY1 SRPK1 STUB1 SUMO2 TADA2A TAF3 TAF8 TANK TBPL2 TP53 TRAF1 TRIM54 TSC22D4 TXNIP UBR5 USHBP1 ZBTB7B ZC3H12A ZNF131	19 interacting genes: ADAMTSL4 CCDC90B CRMP1 CYSRT1 EEF1G GORASP2 HRAS KAT5 KAT7 KPNA2 KPRP KRAS KRTAP10-8 NOTCH2NLA NRAS RAC1 RALA RAP1B UNC119
Entrez ID		3838	5863
HPRD ID		02818	03810
Ensembl ID		ENSG00000182481	ENSG00000237441
Uniprot IDs		P52292	A0A024RCS9 O15211
PDB IDs		1EFX 1QGK 1QGR 3FEX 3FEY 3WPT 4E4V 4WV6 5H43 7CRU 7N8J 7N9H 8FZK 8GCN	8AU4 8B69
Enriched GO Terms of Interacting Partners?		Nucleus Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Identical Protein Binding Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Chromatin Organization Regulation Of Programmed Cell Death Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin Protein Ligase Binding Intracellular Signal Transduction DNA Damage Response Cytoplasm Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Regulation Of Signal Transduction Negative Regulation Of Biosynthetic Process Cytosol Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Intracellular Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Protein Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Nuclear Inclusion Body Positive Regulation Of Proteolysis Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus	G Protein Activity GDP Binding Small GTPase-mediated Signal Transduction GTPase Activity GTP Binding Ras Protein Signal Transduction Intracellular Signaling Cassette Regulation Of Neuronal Synaptic Plasticity Histone H4K16 Acetyltransferase Activity Intracellular Signal Transduction Histone H4 Acetyltransferase Activity Developmental Process Peptidyl-lysine Acetylation Positive Regulation Of Ruffle Assembly Cell Development Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Rac Protein Signal Transduction Regulation Of Receptor-mediated Endocytosis Histone Acetyltransferase Complex Regulation Of Long-term Neuronal Synaptic Plasticity Signal Transduction Golgi Membrane Regulation Of Ruffle Assembly Protein-containing Complex Binding Negative Regulation Of Receptor-mediated Endocytosis Histone Acetyltransferase Activity Protein Acetylation Protein-membrane Adaptor Activity Endoplasmic Reticulum Membrane Establishment Of Skin Barrier Homeostasis Of Number Of Cells Within A Tissue Semaphorin-plexin Signaling Pathway Regulation Of Postsynapse Assembly Histone H2AK5 Acetyltransferase Activity Histone H3K23 Acetyltransferase Activity Histone H3K4 Acetyltransferase Activity Pigment Cell Development Skin Epidermis Development Hydrolase Activity Response To Radiation Endocytosis Regulation Of Cell Projection Assembly Regulation Of Synaptic Plasticity Positive Regulation Of Cellular Component Biogenesis Cellular Developmental Process GTPase Complex Cellular Senescence Modulation Of Chemical Synaptic Transmission MAPK Cascade Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin
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