KPNA2 and APOBEC1

Number of citations of the paper that reports this interaction (PMID 12881431)
31

Data Source:
HPRD (two hybrid)

		KPNA2	APOBEC1
Gene Name		karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane	Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Protein Transporter Activity Histone Deacetylase Binding Poly(A) RNA Binding	RNA Binding Cytidine Deaminase Activity Protein Binding Zinc Ion Binding AU-rich Element Binding
	Biological Process	Regulation Of DNA Recombination DNA Metabolic Process NLS-bearing Protein Import Into Nucleus Viral Process Cytokine-mediated Signaling Pathway	RNA Processing MRNA Processing Lipid Metabolic Process Response To Osmotic Stress Cytidine Deamination Response To Zinc Ion Response To Gamma Radiation Gene Expression Cytidine To Uridine Editing MRNA Modification Cellular Response To Insulin Stimulus Regulation Of Cell Proliferation Lipoprotein Biosynthetic Process Response To Drug Lipoprotein Transport Response To Ethanol MRNA Stabilization Response To Calcium Ion Defense Response To Virus DNA Demethylation Negative Regulation Of Methylation-dependent Chromatin Silencing
Pathways		ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes	mRNA Editing: C to U Conversion mRNA Editing Formation of the Editosome
Drugs
Diseases
GWAS
Protein-Protein Interactions		104 interactors: ACTN1 ACTN4 ANKIB1 AP2B1 APOBEC1 APP ARL4A ARL5A BRCA1 BTBD2 CASP2 CCDC107 CDA CDK5RAP3 CHD3 CHEK2 CORO1B CREB3L3 CREBBP CSE1L CSNK1A1 CUL4B DCTN2 DDIT3 EP300 EPB41 FEZ2 FN1 FTH1 GART GMCL1 GRB2 H1F0 HAP1 HMG20A HNRNPC HOMER2 HOMEZ HSPA4 IFT20 IMMT INO80E ITK JUN KLC4 KPNB1 KRT18 KRT40 KRT8 LAMB2 LEF1 LZTS2 MAGED1 MAGEH1 MDFI MLH1 MORC3 MVP MYC NECAB2 NFKBIB NMNAT1 NR3C1 NUP153 NUP50 NUP62 NUTM1 PAX5 PLAG1 PNMA5 PRKD3 PTMA RAG1 RAN RANBP2 RBM48 RBPMS RECQL RELA RELB RGL2 RILP RNMT SART3 SERTAD3 SGK1 SLC2A2 SPRY1 SRPK1 TADA2A TAF3 TAF8 TANK TBPL2 TP53 TRAF1 TRIM54 TSC22D4 TXNIP UBR5 USHBP1 ZBTB7B ZC3H12A ZNF131	7 interactors: A1CF APOBEC2 BAG4 CELF2 DNAJB11 KPNA2 SYNCRIP
Entrez ID		3838	339
HPRD ID		02818	02531
Ensembl ID		ENSG00000182481	ENSG00000111701
Uniprot IDs		P52292 Q7Z726	P41238
PDB IDs		1EFX 1QGK 1QGR 3FEX 3FEY 4E4V
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Cellular Process RNA Biosynthetic Process Gene Expression Response To Stimulus Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Cell Death Death Apoptotic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process Programmed Cell Death Viral Process Organelle Organization Regulation Of Nucleic Acid-templated Transcription Signal Transduction Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Developmental Process Regulation Of Transcription, DNA-templated Signaling Positive Regulation Of Transcription, DNA-templated Protein Localization To Nucleus Macromolecule Biosynthetic Process Cellular Localization Cell Cycle Negative Regulation Of Biosynthetic Process Cell Communication Negative Regulation Of Nucleic Acid-templated Transcription Cellular Process Negative Regulation Of RNA Biosynthetic Process Cell Cycle Process Response To Stress Positive Regulation Of Gene Expression Nucleocytoplasmic Transport Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Nuclear Transport Positive Regulation Of Macromolecule Biosynthetic Process Multicellular Organismal Development	MRNA Modification MRNA Metabolic Process MRNA Processing RNA Modification RNA Processing Negative Regulation Of MRNA Modification Negative Regulation Of Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Cytokine Stimulus Cellular Nitrogen Compound Metabolic Process Cytidine To Uridine Editing RNA Metabolic Process Response To Cytokine Nitrogen Compound Metabolic Process Cellular Response To Organic Substance CRD-mediated MRNA Stabilization MRNA Localization Resulting In Posttranscriptional Regulation Of Gene Expression Base Conversion Or Substitution Editing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cytidine Deamination Cellular Metabolic Process Protein Folding Intracellular MRNA Localization Positive Regulation Of Fibroblast Migration Response To Organic Substance RNA Splicing Regulation Of Metabolic Process DNA Demethylation Pyrimidine Nucleoside Catabolic Process NLS-bearing Protein Import Into Nucleus Ruffle Assembly Posttranscriptional Regulation Of Gene Expression Cellular Response To Epidermal Growth Factor Stimulus MRNA Stabilization Response To Epidermal Growth Factor Regulation Of Fibroblast Migration Viral Process Gene Expression Ruffle Organization MRNA Splice Site Selection Positive Regulation Of Stress Fiber Assembly
Tagcloud ?		aggressive aggressiveness assembled attempt carcinomas curable diagnostics disregarding eic emgd endometrial entities figo immunoreactivity interplay introducing malignancy mediator mfe microarrays nucleocytoplasmic precancerous regimens surgically tmas trp53 tumour untreatable uterus	aid apolipoprotein atherosclerosis atherosclerotic causal coincident crosses dissecting dyslipidemia editing founder genotyped hampers haplotypes hfca hidden inbred informative mapping markov multiparental outbred qtl reconstructed renders trait triglyceride triglycerides
Tagcloud (Difference) ?		aggressive aggressiveness assembled attempt carcinomas curable diagnostics disregarding eic emgd endometrial entities figo immunoreactivity interplay introducing malignancy mediator mfe microarrays nucleocytoplasmic precancerous regimens surgically tmas trp53 tumour untreatable uterus	aid apolipoprotein atherosclerosis atherosclerotic causal coincident crosses dissecting dyslipidemia editing founder genotyped hampers haplotypes hfca hidden inbred informative mapping markov multiparental outbred qtl reconstructed renders trait triglyceride triglycerides
Tagcloud (Intersection) ?