KPNA2 and NR3C1

Number of citations of the paper that reports this interaction (PubMedID 12933681)
0

Data Source:
HPRD (in vivo)

		KPNA2	NR3C1
Description		karyopherin subunit alpha 2	nuclear receptor subfamily 3 group C member 1
Image
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Nuclear Membrane NLS-dependent Protein Nuclear Import Complex Host Cell	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Mitochondrion Mitochondrial Matrix Centrosome Spindle Cytosol Cytoskeleton Membrane Nuclear Speck Protein-containing Complex Synapse
	Molecular Function	RNA Binding Protein Binding Nuclear Localization Sequence Binding Histone Deacetylase Binding Nuclear Import Signal Receptor Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity RNA Binding Nuclear Receptor Activity Nuclear Glucocorticoid Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Lipid Binding TBP-class Protein Binding Protein Kinase Binding Estrogen Response Element Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding Hsp90 Protein Binding Steroid Hormone Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Regulation Of DNA Recombination DNA Metabolic Process Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Protein Transport Positive Regulation Of Type I Interferon Production Non-canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-templated Transcription Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Positive Regulation Of Viral Life Cycle	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gluconeogenesis Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Chromosome Segregation Signal Transduction Glucocorticoid Metabolic Process Response To Wounding Gene Expression Microglia Differentiation Adrenal Gland Development Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Regulation Of Glucocorticoid Biosynthetic Process Nuclear Receptor-mediated Corticosteroid Signaling Pathway Synaptic Transmission, Glutamatergic Maternal Behavior Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Astrocyte Differentiation Cell Division Response To Glucocorticoid Response To Cortisol Mammary Gland Duct Morphogenesis Motor Behavior Cellular Response To Steroid Hormone Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Dexamethasone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Neuroinflammatory Response Response To Ketone Positive Regulation Of MiRNA Transcription
Pathways		CaMK IV-mediated phosphorylation of CREB ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Sensing of DNA Double Strand Breaks Estrogen-dependent gene expression SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand SUMOylation of intracellular receptors PTK6 Expression Regulation of RUNX2 expression and activity FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Potential therapeutics for SARS Regulation of NPAS4 gene transcription
Drugs			Flunisolide Diflorasone Alclometasone Medrysone Amcinonide Fluorometholone Megestrol acetate Levonorgestrel Beclomethasone dipropionate Progesterone Spironolactone Betamethasone Desoximetasone Fluticasone propionate Fluocinolone acetonide Ulobetasol Triamcinolone Prednisone Flumethasone Fludrocortisone Norethisterone Hydrocortisone Mometasone Hydrocortamate Mifepristone Clocortolone Flurandrenolide Prednisolone Loteprednol etabonate Rimexolone Methylprednisolone Clobetasol propionate Fluocinonide Prednicarbate Fluoxymesterone Budesonide Dexamethasone Desonide Cortisone acetate Paramethasone Drospirenone Ciclesonide Hexane-1,6-Diol Aldosterone ORG-34517 Difluprednate Ulipristal Fluticasone furoate Tixocortol Difluocortolone Gestrinone Deflazacort Onapristone Cortivazol Clobetasone Fluticasone Mometasone furoate Hydrocortisone aceponate Hydrocortisone acetate Hydrocortisone butyrate Hydrocortisone cypionate Hydrocortisone phosphate Hydrocortisone probutate Hydrocortisone valerate Segesterone acetate Prednisolone phosphate Dexamethasone acetate Betamethasone phosphate Prednisolone acetate
Diseases			46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency
GWAS		Brain morphology (MOSTest) ( 32665545) Feeling lonely ( 29500382) General risk tolerance (MTAG) ( 30643258) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889)	Appendicular lean mass ( 33097823) Atrial fibrillation ( 29892015 30061737) Hip circumference adjusted for BMI ( 34021172) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Night sleep phenotypes ( 27126917) PR interval ( 32439900) Spatial processing ( 31596458)
Interacting Genes		111 interacting genes: ACTN1 ACTN4 ANKIB1 AP2B1 APOBEC1 APP ARL4A ARL5A ATXN3 BAG6 BRCA1 BTBD2 CASP2 CCDC107 CDA CDC42 CDK5RAP3 CHD3 CHEK2 CORO1B CREB3L3 CREBBP CSNK1A1 CUL4B DCPS DCTN2 DDIT3 EIF4ENIF1 EP300 EPB41 FEZ2 FN1 FTH1 GART GMCL1 GRB2 GTF2IRD1 H1-0 HAP1 HMG20A HNRNPC HOMER2 HOMEZ HSPA4 IFT20 IMMT INO80E ITK JUN KLC4 KPNB1 KRT18 KRT40 KRT8 LAMB2 LEF1 LZTS2 MAGED1 MAGEH1 MDFI MLH1 MORC3 MORF4L1 MVP NECAB2 NFE2L2 NFKBIB NMNAT1 NR3C1 NUP153 NUP50 NUP62 NUTM1 OGT PAX5 PLAG1 PNMA5 PRKD3 PTMA RAG1 RANBP2 RBM48 RBPMS RECQL RELA RELB RGL2 RILP RNMT SERTAD3 SGK1 SLC2A2 SPRY1 SRPK1 STUB1 SUMO2 TADA2A TAF3 TAF8 TANK TBPL2 TP53 TRAF1 TRIM54 TSC22D4 TXNIP UBR5 USHBP1 ZBTB7B ZC3H12A ZNF131	167 interacting genes: ABCC1 ADA AR ARPC5 BAG1 C1orf94 CALM1 CALR CEBPA CEBPB CENPB CHD9 COPS6 CREB1 CREBBP DAP3 DAPK1 DCAF6 DDX54 DNMT3L DOCK3 DTD1 ECD EFHC2 EGFR EP300 EPB41L1 ETS1 ETS2 FAM161B FKBP4 FTH1 FYN GNB1 GNB2 GRIP1 H3C1 HDAC1 HDAC6 HMGB1 HMGB2 HMOX2 HNRNPA1 HNRNPU HSP90AA1 HSP90AB1 HSPA1A HSPD1 IDE IFNGR2 JMJD1C JUN KAT5 KDM5A KPNA2 KRTCAP3 LCK LCOR LPXN LRIF1 MAFF MAPK1 MAPK15 MAPK8 MDM2 MED1 MED14 MED25 MSX2 NCL NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NEDD4L NFKB1 NFKB2 NR0B1 NR0B2 NR1H3 NR2E3 NR2F2 NR2F6 NR3C2 NR4A1 NRIP1 NUP54 ONECUT1 OSGEP PBX1 PELP1 PIAS2 POLR1D POU1F1 POU2F1 POU2F2 PPARGC1A PRDX3 PRKACA PRKDC PRPF6 PSMC3IP PTGES3 PTMS RACK1 RAD54L2 RAD9A RAF1 RAN RARA RBM14 RELA RFPL2 RNF14 RXRB SFN SGTA SHKBP1 SLC25A4 SMAD3 SMARCA2 SMARCA4 SMARCB1 SMARCC1 SMARCD1 SMARCE1 SPIN2A SRA1 SRC STAT3 STAT5A STAT5B STRN3 STUB1 SUMO1 SUMO4 SVIL SYT1 TADA2A TBP TDG TGFB1I1 TMF1 TNS4 TP53 TRIM24 TRIM28 TSG101 TXN UBB UBE2I UBE2L3 UBE3A UBR1 UBR5 UHRF1 USP2 WTIP YWHAH ZBTB16 ZBTB20 ZBTB3 ZBTB9 ZNF496
Entrez ID		3838	2908
HPRD ID		02818	00679
Ensembl ID		ENSG00000182481	ENSG00000113580
Uniprot IDs		P52292	E5KQF5 E5KQF6 F1D8N4 P04150
PDB IDs		1EFX 1QGK 1QGR 3FEX 3FEY 3WPT 4E4V 4WV6 5H43 7CRU 7N8J 7N9H 8FZK 8GCN	1M2Z 1NHZ 1P93 3BQD 3CLD 3E7C 3H52 3K22 3K23 4CSJ 4HN5 4HN6 4LSJ 4MDD 4P6W 4P6X 4UDC 4UDD 5CBX 5CBY 5CBZ 5CC1 5E69 5E6A 5E6B 5E6C 5E6D 5EMC 5EMP 5EMQ 5G3J 5G5W 5NFP 5NFT 5UC1 5UC3 5VA0 5VA7 6BQU 6CFN 6DXK 6EL6 6EL7 6EL9 6X6D 6X6E 6YMO 6YO8 6YOS 7KRJ 7KW7 7PRV 7PRW 7PRX 8A9G 8FFV 8FFW 8VKZ
Enriched GO Terms of Interacting Partners?		Nucleus Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Identical Protein Binding Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Chromatin Organization Regulation Of Programmed Cell Death Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin Protein Ligase Binding Intracellular Signal Transduction DNA Damage Response Cytoplasm Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Regulation Of Signal Transduction Negative Regulation Of Biosynthetic Process Cytosol Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Intracellular Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Protein Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Nuclear Inclusion Body Positive Regulation Of Proteolysis Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Nucleoplasm Nucleus Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Transcription Coactivator Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II DNA Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Response To Lipid Negative Regulation Of Biosynthetic Process Chromatin Binding Response To Hormone Nuclear Receptor-mediated Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nuclear Receptor Binding Nuclear Glucocorticoid Receptor Binding Intracellular Signal Transduction Transcription Cis-regulatory Region Binding Protein-containing Complex Hormone-mediated Signaling Pathway Transcription Regulator Complex Enzyme Binding Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Cellular Response To Hormone Stimulus
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