KPNA2 and HNRNPC

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid, two hybrid)

		KPNA2	HNRNPC
Gene Name		karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	heterogeneous nuclear ribonucleoprotein C (C1/C2)
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane	Nuclear Chromatin Nucleus Nucleoplasm Spliceosomal Complex Cytosol Membrane Protein Complex Extracellular Vesicular Exosome Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Protein Transporter Activity Histone Deacetylase Binding Poly(A) RNA Binding	Nucleotide Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Poly(U) RNA Binding Nucleosomal DNA Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	Regulation Of DNA Recombination DNA Metabolic Process NLS-bearing Protein Import Into Nucleus Viral Process Cytokine-mediated Signaling Pathway	MRNA Splicing, Via Spliceosome Osteoblast Differentiation RNA Splicing Gene Expression ATP-dependent Chromatin Remodeling 3'-UTR-mediated MRNA Stabilization
Pathways		ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Bipolar disorder ( 21738484)
Protein-Protein Interactions		104 interactors: ACTN1 ACTN4 ANKIB1 AP2B1 APOBEC1 APP ARL4A ARL5A BRCA1 BTBD2 CASP2 CCDC107 CDA CDK5RAP3 CHD3 CHEK2 CORO1B CREB3L3 CREBBP CSE1L CSNK1A1 CUL4B DCTN2 DDIT3 EP300 EPB41 FEZ2 FN1 FTH1 GART GMCL1 GRB2 H1F0 HAP1 HMG20A HNRNPC HOMER2 HOMEZ HSPA4 IFT20 IMMT INO80E ITK JUN KLC4 KPNB1 KRT18 KRT40 KRT8 LAMB2 LEF1 LZTS2 MAGED1 MAGEH1 MDFI MLH1 MORC3 MVP MYC NECAB2 NFKBIB NMNAT1 NR3C1 NUP153 NUP50 NUP62 NUTM1 PAX5 PLAG1 PNMA5 PRKD3 PTMA RAG1 RAN RANBP2 RBM48 RBPMS RECQL RELA RELB RGL2 RILP RNMT SART3 SERTAD3 SGK1 SLC2A2 SPRY1 SRPK1 TADA2A TAF3 TAF8 TANK TBPL2 TP53 TRAF1 TRIM54 TSC22D4 TXNIP UBR5 USHBP1 ZBTB7B ZC3H12A ZNF131	48 interactors: AP1M1 BARD1 BRCA1 BRCA2 BRIP1 BTRC CCDC85B CDKN2A CELF1 CSNK1A1 CSNK2A1 CSNK2A2 DHX9 EPS8 ERG FAS FXR2 GRB2 HNRNPD IL7R KHDRBS3 KPNA2 KPNA3 KPNA4 KRAS LMO2 LMO3 PALB2 PDGFB PHKB PIN1 PRKDC PTBP2 RAD51 RALY RALYL RBM41 SDCBP SF3B2 SMARCD1 SREK1 SRPK2 SUMO1 SUMO1P1 UBE2I YWHAQ ZFYVE26 ZNF581
Entrez ID		3838	3183
HPRD ID		02818	01243
Ensembl ID		ENSG00000182481	ENSG00000092199
Uniprot IDs		P52292 Q7Z726	P07910
PDB IDs		1EFX 1QGK 1QGR 3FEX 3FEY 4E4V	1TXP 1WF2 3LN4
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Cellular Process RNA Biosynthetic Process Gene Expression Response To Stimulus Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Cell Death Death Apoptotic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process Programmed Cell Death Viral Process Organelle Organization Regulation Of Nucleic Acid-templated Transcription Signal Transduction Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Developmental Process Regulation Of Transcription, DNA-templated Signaling Positive Regulation Of Transcription, DNA-templated Protein Localization To Nucleus Macromolecule Biosynthetic Process Cellular Localization Cell Cycle Negative Regulation Of Biosynthetic Process Cell Communication Negative Regulation Of Nucleic Acid-templated Transcription Cellular Process Negative Regulation Of RNA Biosynthetic Process Cell Cycle Process Response To Stress Positive Regulation Of Gene Expression Nucleocytoplasmic Transport Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Nuclear Transport Positive Regulation Of Macromolecule Biosynthetic Process Multicellular Organismal Development	Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cell Cycle Process Nitrogen Compound Metabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To Stimulus Cell Cycle Double-strand Break Repair Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing RNA Splicing, Via Transesterification Reactions Cellular Metabolic Process Regulation Of Cell Cycle Cellular Response To Organic Substance MRNA Processing DNA Repair Cellular Response To Cytokine Stimulus Regulation Of Cellular Process Response To Stimulus Positive Regulation Of Signal Transduction Cellular Response To DNA Damage Stimulus Cellular Response To Stress DNA Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Gene Expression DNA Recombination Response To Cytokine Regulation Of Protein Metabolic Process MRNA Metabolic Process Response To Organic Substance Regulation Of Cellular Component Organization Response To Ionizing Radiation Regulation Of Transcription, DNA-templated Regulation Of Cellular Protein Metabolic Process Developmental Process Positive Regulation Of Cellular Metabolic Process NLS-bearing Protein Import Into Nucleus RNA Processing Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Mitotic Cell Cycle
Tagcloud ?		aggressive aggressiveness assembled attempt carcinomas curable diagnostics disregarding eic emgd endometrial entities figo immunoreactivity interplay introducing malignancy mediator mfe microarrays nucleocytoplasmic precancerous regimens surgically tmas trp53 tumour untreatable uterus	17th 2d appreciation coordinately coupling d deep dihydroxyvitamin entitled epigenome exerts expanded extra fine hormones issue linking locations microrna ribonucleoprotein special splicing steroid transcriptionally tuning vdr vdre vitamin workshop
Tagcloud (Difference) ?		aggressive aggressiveness assembled attempt carcinomas curable diagnostics disregarding eic emgd endometrial entities figo immunoreactivity interplay introducing malignancy mediator mfe microarrays nucleocytoplasmic precancerous regimens surgically tmas trp53 tumour untreatable uterus	17th 2d appreciation coordinately coupling d deep dihydroxyvitamin entitled epigenome exerts expanded extra fine hormones issue linking locations microrna ribonucleoprotein special splicing steroid transcriptionally tuning vdr vdre vitamin workshop
Tagcloud (Intersection) ?