KPNA2 and RECQL

Number of citations of the paper that reports this interaction (PMID 9168958)
25

Data Source:
BioGRID (pull down)
HPRD (two hybrid, in vitro)

		KPNA2	RECQL
Gene Name		karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	RecQ helicase-like
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane	Nucleus Nucleoplasm Membrane
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Protein Transporter Activity Histone Deacetylase Binding Poly(A) RNA Binding	DNA Binding DNA Helicase Activity ATP-dependent DNA Helicase Activity Protein Binding ATP Binding Annealing Helicase Activity ATP-dependent 3'-5' DNA Helicase Activity
	Biological Process	Regulation Of DNA Recombination DNA Metabolic Process NLS-bearing Protein Import Into Nucleus Viral Process Cytokine-mediated Signaling Pathway	DNA Strand Renaturation DNA Replication DNA Repair DNA Recombination DNA Duplex Unwinding
Pathways		ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes
Drugs
Diseases
GWAS
Protein-Protein Interactions		104 interactors: ACTN1 ACTN4 ANKIB1 AP2B1 APOBEC1 APP ARL4A ARL5A BRCA1 BTBD2 CASP2 CCDC107 CDA CDK5RAP3 CHD3 CHEK2 CORO1B CREB3L3 CREBBP CSE1L CSNK1A1 CUL4B DCTN2 DDIT3 EP300 EPB41 FEZ2 FN1 FTH1 GART GMCL1 GRB2 H1F0 HAP1 HMG20A HNRNPC HOMER2 HOMEZ HSPA4 IFT20 IMMT INO80E ITK JUN KLC4 KPNB1 KRT18 KRT40 KRT8 LAMB2 LEF1 LZTS2 MAGED1 MAGEH1 MDFI MLH1 MORC3 MVP MYC NECAB2 NFKBIB NMNAT1 NR3C1 NUP153 NUP50 NUP62 NUTM1 PAX5 PLAG1 PNMA5 PRKD3 PTMA RAG1 RAN RANBP2 RBM48 RBPMS RECQL RELA RELB RGL2 RILP RNMT SART3 SERTAD3 SGK1 SLC2A2 SPRY1 SRPK1 TADA2A TAF3 TAF8 TANK TBPL2 TP53 TRAF1 TRIM54 TSC22D4 TXNIP UBR5 USHBP1 ZBTB7B ZC3H12A ZNF131	3 interactors: KPNA2 KPNA4 RPA1
Entrez ID		3838	5965
HPRD ID		02818	02762
Ensembl ID		ENSG00000182481	ENSG00000004700
Uniprot IDs		P52292 Q7Z726	P46063
PDB IDs		1EFX 1QGK 1QGR 3FEX 3FEY 4E4V	2V1X 2WWY
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Cellular Process RNA Biosynthetic Process Gene Expression Response To Stimulus Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Cell Death Death Apoptotic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process Programmed Cell Death Viral Process Organelle Organization Regulation Of Nucleic Acid-templated Transcription Signal Transduction Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Developmental Process Regulation Of Transcription, DNA-templated Signaling Positive Regulation Of Transcription, DNA-templated Protein Localization To Nucleus Macromolecule Biosynthetic Process Cellular Localization Cell Cycle Negative Regulation Of Biosynthetic Process Cell Communication Negative Regulation Of Nucleic Acid-templated Transcription Cellular Process Negative Regulation Of RNA Biosynthetic Process Cell Cycle Process Response To Stress Positive Regulation Of Gene Expression Nucleocytoplasmic Transport Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Nuclear Transport Positive Regulation Of Macromolecule Biosynthetic Process Multicellular Organismal Development	NLS-bearing Protein Import Into Nucleus Protein Import Into Nucleus Nuclear Import Protein Import Protein Localization To Nucleus Nucleocytoplasmic Transport Nuclear Transport DNA Recombinase Assembly Establishment Of Protein Localization To Organelle Protein Targeting Cytokine-mediated Signaling Pathway Protein Localization To Organelle Cellular Response To Cytokine Stimulus Nucleotide-excision Repair, DNA Gap Filling Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Via Semi-conservative Replication Cytoplasmic Transport Response To Cytokine Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Regulation Of Cellular Response To Heat DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Intracellular Protein Transport Homeostasis Of Number Of Cells Within A Tissue Transcription-coupled Nucleotide-excision Repair DNA Metabolic Process Mismatch Repair Base-excision Repair Cellular Response To Heat Regulation Of DNA Recombination Cellular Protein Localization Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Recombinational Repair Protein Transport Establishment Of Protein Localization Nucleotide-excision Repair Intracellular Transport DNA-dependent DNA Replication Response To Heat Response To Hydrogen Peroxide
Tagcloud ?		aggressive aggressiveness assembled attempt carcinomas curable diagnostics disregarding eic emgd endometrial entities figo immunoreactivity interplay introducing malignancy mediator mfe microarrays nucleocytoplasmic precancerous regimens surgically tmas trp53 tumour untreatable uterus	affymetrix candidate candidates ccnd1 ccnd3 chosen cisplatin details head hg hour ic50 identifying line map map2k6 microarray microarrays moderately neck others parent resistance squamous tca tca8113 tongue u95av2 validate
Tagcloud (Difference) ?		aggressive aggressiveness assembled attempt carcinomas curable diagnostics disregarding eic emgd endometrial entities figo immunoreactivity interplay introducing malignancy mediator mfe nucleocytoplasmic precancerous regimens surgically tmas trp53 tumour untreatable uterus	affymetrix candidate candidates ccnd1 ccnd3 chosen cisplatin details head hg hour ic50 identifying line map map2k6 microarray moderately neck others parent resistance squamous tca tca8113 tongue u95av2 validate
Tagcloud (Intersection) ?		microarrays