KPNA2 and FTH1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		KPNA2	FTH1
Gene Name		karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	ferritin, heavy polypeptide 1
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane	Nucleus Mitochondrion Cytosol Intracellular Ferritin Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Protein Transporter Activity Histone Deacetylase Binding Poly(A) RNA Binding	Ferroxidase Activity Iron Ion Binding Protein Binding Ferric Iron Binding
	Biological Process	Regulation Of DNA Recombination DNA Metabolic Process NLS-bearing Protein Import Into Nucleus Viral Process Cytokine-mediated Signaling Pathway	Iron Ion Transport Cellular Iron Ion Homeostasis Intracellular Sequestering Of Iron Ion Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Immune Response Negative Regulation Of Cell Proliferation Negative Regulation Of Fibroblast Proliferation Transmembrane Transport Oxidation-reduction Process Membrane Organization
Pathways		ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes	Iron uptake and transport Golgi Associated Vesicle Biogenesis Scavenging by Class A Receptors trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs			Iron Dextran
Diseases
GWAS			Estradiol levels ( 22675492) Phospholipid levels (plasma) ( 21829377)
Protein-Protein Interactions		104 interactors: ACTN1 ACTN4 ANKIB1 AP2B1 APOBEC1 APP ARL4A ARL5A BRCA1 BTBD2 CASP2 CCDC107 CDA CDK5RAP3 CHD3 CHEK2 CORO1B CREB3L3 CREBBP CSE1L CSNK1A1 CUL4B DCTN2 DDIT3 EP300 EPB41 FEZ2 FN1 FTH1 GART GMCL1 GRB2 H1F0 HAP1 HMG20A HNRNPC HOMER2 HOMEZ HSPA4 IFT20 IMMT INO80E ITK JUN KLC4 KPNB1 KRT18 KRT40 KRT8 LAMB2 LEF1 LZTS2 MAGED1 MAGEH1 MDFI MLH1 MORC3 MVP MYC NECAB2 NFKBIB NMNAT1 NR3C1 NUP153 NUP50 NUP62 NUTM1 PAX5 PLAG1 PNMA5 PRKD3 PTMA RAG1 RAN RANBP2 RBM48 RBPMS RECQL RELA RELB RGL2 RILP RNMT SART3 SERTAD3 SGK1 SLC2A2 SPRY1 SRPK1 TADA2A TAF3 TAF8 TANK TBPL2 TP53 TRAF1 TRIM54 TSC22D4 TXNIP UBR5 USHBP1 ZBTB7B ZC3H12A ZNF131	31 interactors: BRD7 CD99 CDC16 CDC25A CRMP1 CSF3R CSNK2B DAXX ELL3 FTL FXR2 GOLM1 GRB2 KPNA2 LBP MAX MYL3 NR1I3 NR3C1 NR5A2 PACSIN1 PIAS4 SDCBP SOX5 SPP1 TICAM2 TOLLIP TRAF4 UBR1 WDYHV1 YWHAE
Entrez ID		3838	2495
HPRD ID		02818	00615
Ensembl ID		ENSG00000182481	ENSG00000167996
Uniprot IDs		P52292 Q7Z726	P02794
PDB IDs		1EFX 1QGK 1QGR 3FEX 3FEY 4E4V	1FHA 2CEI 2CHI 2CIH 2CLU 2CN6 2CN7 2FHA 2IU2 2Z6M 3AJO 3AJP 3AJQ 3ERZ 3ES3 4DYX 4DYY 4DYZ 4DZ0
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Cellular Process RNA Biosynthetic Process Gene Expression Response To Stimulus Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Cell Death Death Apoptotic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process Programmed Cell Death Viral Process Organelle Organization Regulation Of Nucleic Acid-templated Transcription Signal Transduction Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Developmental Process Regulation Of Transcription, DNA-templated Signaling Positive Regulation Of Transcription, DNA-templated Protein Localization To Nucleus Macromolecule Biosynthetic Process Cellular Localization Cell Cycle Negative Regulation Of Biosynthetic Process Cell Communication Negative Regulation Of Nucleic Acid-templated Transcription Cellular Process Negative Regulation Of RNA Biosynthetic Process Cell Cycle Process Response To Stress Positive Regulation Of Gene Expression Nucleocytoplasmic Transport Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Nuclear Transport Positive Regulation Of Macromolecule Biosynthetic Process Multicellular Organismal Development	Positive Regulation Of Cellular Metabolic Process Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Metabolic Process Cellular Response To Stimulus Regulation Of Metabolic Process Chemotaxis Positive Regulation Of Signal Transduction Hormone-mediated Signaling Pathway Response To Stimulus Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Cell Communication Regulation Of Protein Metabolic Process System Development Movement Of Cell Or Subcellular Component Cellular Response To Hormone Stimulus Regulation Of Signal Transduction Generation Of Neurons Anatomical Structure Development Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Toll-like Receptor Signaling Pathway Locomotion Positive Regulation Of Protein Sumoylation Signaling Response To Hormone Neurogenesis Cellular Response To Lipid Leukocyte Migration Signal Transduction Regulation Of Signaling Steroid Hormone Mediated Signaling Pathway Multicellular Organismal Development Regulation Of Protein Sumoylation Response To External Stimulus Leukocyte Chemotaxis Regulation Of Cellular Process Positive Regulation Of Cellular Protein Metabolic Process Developmental Process Positive Regulation Of JNK Cascade Cell Migration Response To Lipid Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Transcription From RNA Polymerase II Promoter Cell Motility Negative Regulation Of Gene Expression
Tagcloud ?		aggressive aggressiveness assembled attempt carcinomas curable diagnostics disregarding eic emgd endometrial entities figo immunoreactivity interplay introducing malignancy mediator mfe microarrays nucleocytoplasmic precancerous regimens surgically tmas trp53 tumour untreatable uterus	aggravating anxa1 banks bedside confidently cons ftl gliosis got2 immunochemical infarct infarcted infarcts itraq lagging leak malate mdh2 mortem plex pros proteome proteomics putamen shuttle slc25a11 slc25a12 tca vim
Tagcloud (Difference) ?		aggressive aggressiveness assembled attempt carcinomas curable diagnostics disregarding eic emgd endometrial entities figo immunoreactivity interplay introducing malignancy mediator mfe microarrays nucleocytoplasmic precancerous regimens surgically tmas trp53 tumour untreatable uterus	aggravating anxa1 banks bedside confidently cons ftl gliosis got2 immunochemical infarct infarcted infarcts itraq lagging leak malate mdh2 mortem plex pros proteome proteomics putamen shuttle slc25a11 slc25a12 tca vim
Tagcloud (Intersection) ?