KPNA2 and PLAG1

Number of citations of the paper that reports this interaction (PMID 11882654)
9

Data Source:
HPRD (in vitro, two hybrid)

		KPNA2	PLAG1
Gene Name		karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	pleiomorphic adenoma gene 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane	Nucleus
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Protein Transporter Activity Histone Deacetylase Binding Poly(A) RNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Metal Ion Binding
	Biological Process	Regulation Of DNA Recombination DNA Metabolic Process NLS-bearing Protein Import Into Nucleus Viral Process Cytokine-mediated Signaling Pathway	Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Gland Morphogenesis Multicellular Organism Growth Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Glial Cell Proliferation Prostate Gland Growth
Pathways		ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes
Drugs
Diseases
GWAS			Height ( 19396169 19343178 19893584 18391951 20189936)
Protein-Protein Interactions		104 interactors: ACTN1 ACTN4 ANKIB1 AP2B1 APOBEC1 APP ARL4A ARL5A BRCA1 BTBD2 CASP2 CCDC107 CDA CDK5RAP3 CHD3 CHEK2 CORO1B CREB3L3 CREBBP CSE1L CSNK1A1 CUL4B DCTN2 DDIT3 EP300 EPB41 FEZ2 FN1 FTH1 GART GMCL1 GRB2 H1F0 HAP1 HMG20A HNRNPC HOMER2 HOMEZ HSPA4 IFT20 IMMT INO80E ITK JUN KLC4 KPNB1 KRT18 KRT40 KRT8 LAMB2 LEF1 LZTS2 MAGED1 MAGEH1 MDFI MLH1 MORC3 MVP MYC NECAB2 NFKBIB NMNAT1 NR3C1 NUP153 NUP50 NUP62 NUTM1 PAX5 PLAG1 PNMA5 PRKD3 PTMA RAG1 RAN RANBP2 RBM48 RBPMS RECQL RELA RELB RGL2 RILP RNMT SART3 SERTAD3 SGK1 SLC2A2 SPRY1 SRPK1 TADA2A TAF3 TAF8 TANK TBPL2 TP53 TRAF1 TRIM54 TSC22D4 TXNIP UBR5 USHBP1 ZBTB7B ZC3H12A ZNF131	5 interactors: KPNA2 PIAS1 PIAS2 PIAS4 SMAD3
Entrez ID		3838	5324
HPRD ID		02818	04321
Ensembl ID		ENSG00000182481	ENSG00000181690
Uniprot IDs		P52292 Q7Z726	Q6DJT9
PDB IDs		1EFX 1QGK 1QGR 3FEX 3FEY 4E4V
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Cellular Process RNA Biosynthetic Process Gene Expression Response To Stimulus Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Cell Death Death Apoptotic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process Programmed Cell Death Viral Process Organelle Organization Regulation Of Nucleic Acid-templated Transcription Signal Transduction Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Developmental Process Regulation Of Transcription, DNA-templated Signaling Positive Regulation Of Transcription, DNA-templated Protein Localization To Nucleus Macromolecule Biosynthetic Process Cellular Localization Cell Cycle Negative Regulation Of Biosynthetic Process Cell Communication Negative Regulation Of Nucleic Acid-templated Transcription Cellular Process Negative Regulation Of RNA Biosynthetic Process Cell Cycle Process Response To Stress Positive Regulation Of Gene Expression Nucleocytoplasmic Transport Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Nuclear Transport Positive Regulation Of Macromolecule Biosynthetic Process Multicellular Organismal Development	Protein Sumoylation Positive Regulation Of Protein Sumoylation Regulation Of Protein Sumoylation Peptidyl-lysine Modification Androgen Receptor Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Protein Modification By Small Protein Conjugation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transforming Growth Factor Beta3 Production Regulation Of Osteoblast Differentiation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Keratinocyte Apoptotic Process Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process Signal Transduction Evasion Or Tolerance Of Host Defenses By Virus Peptidyl-amino Acid Modification Positive Regulation Of Cellular Metabolic Process Regulation Of Ossification Positive Regulation Of Apoptotic Signaling Pathway Intracellular Receptor Signaling Pathway Nitrogen Compound Metabolic Process Signaling Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Regulation Of Signal Transduction Cell Communication Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Extracellular Matrix Assembly Positive Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Primary MiRNA Processing Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Proteolysis RNA Metabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage SMAD Protein Complex Assembly Negative Regulation Of Osteoblast Proliferation Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated
Tagcloud ?		aggressive aggressiveness assembled attempt carcinomas curable diagnostics disregarding eic emgd endometrial entities figo immunoreactivity interplay introducing malignancy mediator mfe microarrays nucleocytoplasmic precancerous regimens surgically tmas trp53 tumour untreatable uterus	batch calling classify cooperative driver exome fer filtering fusions h3f3a indels leukemias lmo1 mllt10 nkx2 normalization normalizations obtaining perturbations pipelines ptk2b seq skipping snv snvs ssbp2 stat5b tlx1 tpm3
Tagcloud (Difference) ?		aggressive aggressiveness assembled attempt carcinomas curable diagnostics disregarding eic emgd endometrial entities figo immunoreactivity interplay introducing malignancy mediator mfe microarrays nucleocytoplasmic precancerous regimens surgically tmas trp53 tumour untreatable uterus	batch calling classify cooperative driver exome fer filtering fusions h3f3a indels leukemias lmo1 mllt10 nkx2 normalization normalizations obtaining perturbations pipelines ptk2b seq skipping snv snvs ssbp2 stat5b tlx1 tpm3
Tagcloud (Intersection) ?