KPNA2 and PLAG1

Number of citations of the paper that reports this interaction (PubMedID 11882654)
0

Data Source:
HPRD (two hybrid, in vitro)

		KPNA2	PLAG1
Description		karyopherin subunit alpha 2	PLAG1 zinc finger
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Nuclear Membrane NLS-dependent Protein Nuclear Import Complex Host Cell	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Nuclear Body Nuclear Speck
	Molecular Function	RNA Binding Protein Binding Nuclear Localization Sequence Binding Histone Deacetylase Binding Nuclear Import Signal Receptor Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Zinc Ion Binding Metal Ion Binding
	Biological Process	Regulation Of DNA Recombination DNA Metabolic Process Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Protein Transport Positive Regulation Of Type I Interferon Production Non-canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-templated Transcription Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Positive Regulation Of Viral Life Cycle	Regulation Of DNA-templated Transcription Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Gland Morphogenesis Multicellular Organism Growth Organ Growth Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Glial Cell Proliferation Prostate Gland Growth
Pathways		CaMK IV-mediated phosphorylation of CREB ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Sensing of DNA Double Strand Breaks Estrogen-dependent gene expression SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Feeling lonely ( 29500382) General risk tolerance (MTAG) ( 30643258) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889)	Appendicular lean mass ( 33097823) Birth weight ( 31043758) Heel bone mineral density ( 30598549) Height ( 19343178 31562340 28552196 25429064 25282103 20189936 19893584 19396169 18391951) Hip circumference adjusted for BMI ( 25673412 34021172) Monocyte count ( 32888494) Plateletcrit ( 32888494) Refractive error ( 32231278)
Interacting Genes		111 interacting genes: ACTN1 ACTN4 ANKIB1 AP2B1 APOBEC1 APP ARL4A ARL5A ATXN3 BAG6 BRCA1 BTBD2 CASP2 CCDC107 CDA CDC42 CDK5RAP3 CHD3 CHEK2 CORO1B CREB3L3 CREBBP CSNK1A1 CUL4B DCPS DCTN2 DDIT3 EIF4ENIF1 EP300 EPB41 FEZ2 FN1 FTH1 GART GMCL1 GRB2 GTF2IRD1 H1-0 HAP1 HMG20A HNRNPC HOMER2 HOMEZ HSPA4 IFT20 IMMT INO80E ITK JUN KLC4 KPNB1 KRT18 KRT40 KRT8 LAMB2 LEF1 LZTS2 MAGED1 MAGEH1 MDFI MLH1 MORC3 MORF4L1 MVP NECAB2 NFE2L2 NFKBIB NMNAT1 NR3C1 NUP153 NUP50 NUP62 NUTM1 OGT PAX5 PLAG1 PNMA5 PRKD3 PTMA RAG1 RANBP2 RBM48 RBPMS RECQL RELA RELB RGL2 RILP RNMT SERTAD3 SGK1 SLC2A2 SPRY1 SRPK1 STUB1 SUMO2 TADA2A TAF3 TAF8 TANK TBPL2 TP53 TRAF1 TRIM54 TSC22D4 TXNIP UBR5 USHBP1 ZBTB7B ZC3H12A ZNF131	5 interacting genes: KPNA2 PIAS1 PIAS2 PIAS4 SMAD3
Entrez ID		3838	5324
HPRD ID		02818	04321
Ensembl ID		ENSG00000182481	ENSG00000181690
Uniprot IDs		P52292	Q6DJT9
PDB IDs		1EFX 1QGK 1QGR 3FEX 3FEY 3WPT 4E4V 4WV6 5H43 7CRU 7N8J 7N9H 8FZK 8GCN
Enriched GO Terms of Interacting Partners?		Nucleus Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Identical Protein Binding Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Chromatin Organization Regulation Of Programmed Cell Death Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin Protein Ligase Binding Intracellular Signal Transduction DNA Damage Response Cytoplasm Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Regulation Of Signal Transduction Negative Regulation Of Biosynthetic Process Cytosol Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Intracellular Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Protein Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Nuclear Inclusion Body Positive Regulation Of Proteolysis Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus	SUMO Ligase Activity SUMO Transferase Activity Protein Sumoylation Ubiquitin Protein Ligase Binding PML Body Transcription Coregulator Activity Positive Regulation Of Protein Sumoylation Transcription Corepressor Activity Regulation Of Protein Sumoylation SMAD Protein Signal Transduction Chromatin Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Lung Blood Pressure Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Mineralocorticoid Receptor Binding Regulation Of RNA Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Positive Regulation Of Transforming Growth Factor Beta3 Production Positive Regulation Of Post-translational Protein Modification Limb Epidermis Development Protein Modification By Small Protein Conjugation Regulation Of DNA Recombination Nucleoplasm DNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Sterol Response Element Binding Zinc Ion Binding Paraxial Mesoderm Morphogenesis Cell Surface Receptor Signaling Pathway Signal Transduction Intracellular Signaling Cassette Viral Penetration Into Host Nucleus DNA Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Lung Blood Pressure DNA-binding Transcription Factor Binding Post-translational Protein Modification Positive Regulation Of Keratinocyte Apoptotic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Biosynthetic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?