LMCD1 and FBXO25

Number of citations of the paper that reports this interaction (PMID 23940030)
0

Data Source:
BioGRID (enzymatic study)

		LMCD1	FBXO25
Gene Name		LIM and cysteine-rich domains 1	F-box protein 25
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Extracellular Matrix	Ubiquitin Ligase Complex Nucleus Nucleolus SCF Ubiquitin Ligase Complex
	Molecular Function	Transcription Corepressor Activity Zinc Ion Binding	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Calcineurin-NFAT Signaling Cascade	Protein Ubiquitination
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: APP FBXO25 IKBKG NKX3-1 PRKAG3 TRIM55 TRIM63	80 interactors: ADRBK1 ANKRD13A APLF AXL BMX C11orf63 C19orf57 C6orf106 C7orf50 CDK5RAP2 CDK9 CENPB CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ING3 IRS1 KDR KRT8 LMCD1 LUC7L MAT2B NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1
Entrez ID		29995	26260
HPRD ID		06891	16439
Ensembl ID		ENSG00000071282	ENSG00000147364
Uniprot IDs		B4DEY6 B4DG80 B7Z6R5 F5GX84 Q9NZU5	Q8TCJ0
PDB IDs
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Interleukin-1 Cellular Response To Hormone Stimulus Positive Regulation Of Mitotic Cell Cycle Synaptic Growth At Neuromuscular Junction Positive Regulation Of Androgen Secretion Signal Transduction Cell Cycle Arrest Regulation Of Protein Binding Positive Regulation Of Peptidase Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Collateral Sprouting In Absence Of Injury Negative Regulation Of Estrogen Receptor Binding Regulation Of Protein Kinase Activity Signaling Cell Communication Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Kinase Activity Cellular Response To Steroid Hormone Stimulus Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Skeletal Muscle Atrophy Regulation Of Cell Cycle Axon Choice Point Recognition Striated Muscle Atrophy Response To Hormone Apoptotic Process Negative Regulation Of Receptor Binding Muscle Atrophy Programmed Cell Death Regulation Of Binding Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stimulus Cell Death Death Neuron Remodeling Skeletal Muscle Adaptation Regulation Of Protein Phosphorylation Positive Regulation Of Cell Cycle Response To Abiotic Stimulus Dorsal Aorta Development Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Protein Metabolic Process Mitotic Cell Cycle Arrest	Regulation Of Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Peptidyl-amino Acid Modification Cellular Metabolic Process Cellular Protein Modification Process Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Response To Stress Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Innate Immune Response Neurotrophin Signaling Pathway Viral Process Protein Phosphorylation Cellular Response To Stimulus Cellular Response To Growth Factor Stimulus Fibroblast Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Response To Growth Factor Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Gene Expression Peptidyl-tyrosine Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Phospholipase C Activity Phosphorylation Intracellular Signal Transduction Regulation Of Cellular Process Rhythmic Process Protein Autophosphorylation Positive Regulation Of Phospholipase Activity Response To Stimulus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Organic Substance Immune Response Proteasomal Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Response To UV-A Peptidyl-serine Autophosphorylation Regulation Of Phospholipase Activity Apoptotic Process Positive Regulation Of Lipase Activity Defense Response Protein Metabolic Process Regulation Of Cell Death Immune System Process Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process
Tagcloud ?		anf antihypertrophic blunted calcineurin cardiomyocyte cardiomyocytes cardiomyopathic causal constitutionally contractile crossed disc dyxin exacerbated hypertrophic hypertrophy likewise lim mechanistically nrcm nrcms pe phenylephrine potently rcan1 sarcomeric stretch stretched upregulated
Tagcloud (Difference) ?		anf antihypertrophic blunted calcineurin cardiomyocyte cardiomyocytes cardiomyopathic causal constitutionally contractile crossed disc dyxin exacerbated hypertrophic hypertrophy likewise lim mechanistically nrcm nrcms pe phenylephrine potently rcan1 sarcomeric stretch stretched upregulated
Tagcloud (Intersection) ?