LMCD1 and NKX3-1

Number of citations of the paper that reports this interaction (PMID 18816836)
2

Data Source:
BioGRID (two hybrid)

		LMCD1	NKX3-1
Gene Name		LIM and cysteine-rich domains 1	NK3 homeobox 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Extracellular Matrix	Intracellular Nucleus
	Molecular Function	Transcription Corepressor Activity Zinc Ion Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity Core Promoter Binding Sequence-specific DNA Binding Transcription Factor Activity Androgen Receptor Activity Protein Binding Transcription Factor Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Estrogen Receptor Activity Protein Kinase Activator Activity Estrogen Receptor Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein Self-association Transcription Regulatory Region DNA Binding MADS Box Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Calcineurin-NFAT Signaling Cascade	Metanephros Development Somitogenesis Positive Regulation Of Protein Phosphorylation Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Multicellular Organismal Development Salivary Gland Development Heart Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Male Gonad Development Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell Death Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Androgen Receptor Signaling Pathway Response To Testosterone Cellular Response To Drug Dorsal Aorta Development Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Steroid Hormone Mediated Signaling Pathway Protein Kinase B Signaling Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Division Pharyngeal System Development Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Steroid Hormone Stimulus Cellular Response To Hypoxia Mitotic Cell Cycle Arrest Negative Regulation Of Estrogen Receptor Binding Positive Regulation Of Androgen Secretion Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: APP FBXO25 IKBKG NKX3-1 PRKAG3 TRIM55 TRIM63	32 interactors: AEN CCT7 CHPF CKAP4 FEM1B HIPK2 HMG20B HNRNPA0 HSP90B1 LMCD1 MAN2B1 MNAT1 ND4 PEBP1 PTMS RABL6 RARG RPL37A RPSA SP1 SP2 SP3 SP4 SP5 SPDEF SRF STMN3 STRA13 TEX264 TOPORS TPT1 WDR77
Entrez ID		29995	4824
HPRD ID		06891	03620
Ensembl ID		ENSG00000071282	ENSG00000167034
Uniprot IDs		B4DEY6 B4DG80 B7Z6R5 F5GX84 Q9NZU5	Q99801
PDB IDs			2L9R
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Interleukin-1 Cellular Response To Hormone Stimulus Positive Regulation Of Mitotic Cell Cycle Synaptic Growth At Neuromuscular Junction Positive Regulation Of Androgen Secretion Signal Transduction Cell Cycle Arrest Regulation Of Protein Binding Positive Regulation Of Peptidase Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Collateral Sprouting In Absence Of Injury Negative Regulation Of Estrogen Receptor Binding Regulation Of Protein Kinase Activity Signaling Cell Communication Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Kinase Activity Cellular Response To Steroid Hormone Stimulus Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Skeletal Muscle Atrophy Regulation Of Cell Cycle Axon Choice Point Recognition Striated Muscle Atrophy Response To Hormone Apoptotic Process Negative Regulation Of Receptor Binding Muscle Atrophy Programmed Cell Death Regulation Of Binding Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stimulus Cell Death Death Neuron Remodeling Skeletal Muscle Adaptation Regulation Of Protein Phosphorylation Positive Regulation Of Cell Cycle Response To Abiotic Stimulus Dorsal Aorta Development Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Protein Metabolic Process Mitotic Cell Cycle Arrest	Nucleobase-containing Compound Metabolic Process RNA Metabolic Process RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription, DNA-templated Embryonic Eye Morphogenesis Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Embryonic Camera-type Eye Development Regulation Of Transcription From RNA Polymerase II Promoter Eye Morphogenesis Biosynthetic Process Megakaryocyte Differentiation Trophectodermal Cell Differentiation Camera-type Eye Development Eye Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Erythrocyte Differentiation Erythrocyte Homeostasis Blastocyst Formation Embryonic Camera-type Eye Morphogenesis Camera-type Eye Morphogenesis Organ Morphogenesis Myeloid Cell Homeostasis Organ Development Embryonic Organ Development Glandular Epithelial Cell Differentiation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Embryonic Organ Morphogenesis Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Embryonic Process Involved In Female Pregnancy Sensory Organ Development Prostate Gland Development Regulation Of RNA Metabolic Process Enucleate Erythrocyte Differentiation Positive Regulation Of Transcription, DNA-templated Tissue Development System Development Homeostasis Of Number Of Cells
Tagcloud ?		anf antihypertrophic blunted calcineurin cardiomyocyte cardiomyocytes cardiomyopathic causal constitutionally contractile crossed disc dyxin exacerbated hypertrophic hypertrophy likewise lim mechanistically nrcm nrcms pe phenylephrine potently rcan1 sarcomeric stretch stretched upregulated
Tagcloud (Difference) ?		anf antihypertrophic blunted calcineurin cardiomyocyte cardiomyocytes cardiomyopathic causal constitutionally contractile crossed disc dyxin exacerbated hypertrophic hypertrophy likewise lim mechanistically nrcm nrcms pe phenylephrine potently rcan1 sarcomeric stretch stretched upregulated
Tagcloud (Intersection) ?