LMCD1 and TRIM55

Number of citations of the paper that reports this interaction (PMID 18157088)
41

Data Source:
BioGRID (two hybrid)

		LMCD1	TRIM55
Gene Name		LIM and cysteine-rich domains 1	tripartite motif containing 55
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Extracellular Matrix	Nucleus Cytoplasm Microtubule
	Molecular Function	Transcription Corepressor Activity Zinc Ion Binding	Signal Transducer Activity Zinc Ion Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Calcineurin-NFAT Signaling Cascade	Signal Transduction
Pathways
Drugs
Diseases
GWAS			Response to statin therapy ( 22666496)
Protein-Protein Interactions		7 interactors: APP FBXO25 IKBKG NKX3-1 PRKAG3 TRIM55 TRIM63	61 interactors: ACTA1 ANKRD1 ATP5B ATXN3 ATXN3L BRAP CKM DCAF6 DES EEF1G EHHADH EIF3E ESPL1 FHL2 FLNA FLNB FLNC GFM1 GMEB1 LMCD1 MDM4 MRPL19 MRPL41 MYBPC1 MYBPC3 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 OTUB1 OTUB2 PCGF1 PIAS1 PIAS2 PIAS3 RNF114 SQSTM1 STAM TCAP TNNI1 TNNI2 TNNI3 TRIM27 TRIM54 TRIM63 TTN UBE2D1 UBE2D2 UBE2D3 UCHL3 UCHL5 USP13 USP28 USP4 USP5 USP7 USP8 UXT YOD1
Entrez ID		29995	84675
HPRD ID		06891	05927
Ensembl ID		ENSG00000071282	ENSG00000147573
Uniprot IDs		B4DEY6 B4DG80 B7Z6R5 F5GX84 Q9NZU5	Q9BYV6
PDB IDs
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Interleukin-1 Cellular Response To Hormone Stimulus Positive Regulation Of Mitotic Cell Cycle Synaptic Growth At Neuromuscular Junction Positive Regulation Of Androgen Secretion Signal Transduction Cell Cycle Arrest Regulation Of Protein Binding Positive Regulation Of Peptidase Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Collateral Sprouting In Absence Of Injury Negative Regulation Of Estrogen Receptor Binding Regulation Of Protein Kinase Activity Signaling Cell Communication Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Kinase Activity Cellular Response To Steroid Hormone Stimulus Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Skeletal Muscle Atrophy Regulation Of Cell Cycle Axon Choice Point Recognition Striated Muscle Atrophy Response To Hormone Apoptotic Process Negative Regulation Of Receptor Binding Muscle Atrophy Programmed Cell Death Regulation Of Binding Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stimulus Cell Death Death Neuron Remodeling Skeletal Muscle Adaptation Regulation Of Protein Phosphorylation Positive Regulation Of Cell Cycle Response To Abiotic Stimulus Dorsal Aorta Development Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Protein Metabolic Process Mitotic Cell Cycle Arrest	Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Protein Deubiquitination Protein Modification By Small Protein Removal Actin Filament-based Movement Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Muscle Contraction Actin Filament-based Process Cellular Protein Catabolic Process Protein Catabolic Process Muscle System Process Protein K48-linked Deubiquitination Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Striated Muscle Cell Development Cellular Protein Metabolic Process Muscle Structure Development Muscle Cell Development Protein K63-linked Deubiquitination Myofibril Assembly Proteolysis Cellular Protein Modification Process Striated Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Striated Muscle Cell Differentiation Muscle Tissue Development Muscle Tissue Morphogenesis Actomyosin Structure Organization Muscle Organ Morphogenesis Cardiac Muscle Tissue Development Protein Metabolic Process Muscle Organ Development Protein Modification By Small Protein Conjugation Muscle Cell Differentiation Myosin Filament Assembly Catabolic Process Actin Cytoskeleton Organization Skeletal Muscle Thin Filament Assembly Cytoskeleton Organization Skeletal Myofibril Assembly Response To Muscle Stretch Heart Morphogenesis Striated Muscle Contraction Cellular Process
Tagcloud ?		anf antihypertrophic blunted calcineurin cardiomyocyte cardiomyocytes cardiomyopathic causal constitutionally contractile crossed disc dyxin exacerbated hypertrophic hypertrophy likewise lim mechanistically nrcm nrcms pe phenylephrine potently rcan1 sarcomeric stretch stretched upregulated
Tagcloud (Difference) ?		anf antihypertrophic blunted calcineurin cardiomyocyte cardiomyocytes cardiomyopathic causal constitutionally contractile crossed disc dyxin exacerbated hypertrophic hypertrophy likewise lim mechanistically nrcm nrcms pe phenylephrine potently rcan1 sarcomeric stretch stretched upregulated
Tagcloud (Intersection) ?